INT61938

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.05
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pxk) nucleus (Pxk) cytoplasm (Pxk)
Pxk (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 99.60 Very High Very High Very High
Migraine 2 99.58 Very High Very High Very High
Potency 14 96.52 Very High Very High Very High
anesthesia 10 84.32 Quite High
Eae 4 69.44 Quite High
adenocard 2 65.76 Quite High
nMDA receptor 2 55.72 Quite High
Neurobehavioral 2 40.08 Quite Low
diclofenac 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.92 Very High Very High Very High
Cataract 42 99.66 Very High Very High Very High
Depression 2 99.60 Very High Very High Very High
Migraine With Aura 2 99.58 Very High Very High Very High
Congenital Anomalies 6 99.34 Very High Very High Very High
Parkinson's Disease 2 98.98 Very High Very High Very High
Dystonia 2 98.72 Very High Very High Very High
Disease 4 98.52 Very High Very High Very High
Injury 10 98.28 Very High Very High Very High
Anxiety Disorder 4 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Negative_regulation (Deficiency) of Na,K-ATPase associated with anxiety disorder
1) Confidence 0.36 Published 2007 Journal J. Neurosci. Section Title Doc Link 17234593 Disease Relevance 0.70 Pain Relevance 0.23
The Na+/K+ -ATPase activity was inhibited by methyl n-propyl ketone alone, membrane DPH fluidity was decreased by each of the 4 monoketones, and membrane TMA-DPH fluidity was decreased by methyl n-propylketone alone.
Negative_regulation (decreased) of Na+/K+ -ATPase
2) Confidence 0.34 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619259 Disease Relevance 0 Pain Relevance 0.40
The Na+/K+ -ATPase activity was inhibited by methyl n-propyl ketone alone, membrane DPH fluidity was decreased by each of the 4 monoketones, and membrane TMA-DPH fluidity was decreased by methyl n-propylketone alone.
Negative_regulation (inhibited) of Na+/K+ -ATPase
3) Confidence 0.34 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619259 Disease Relevance 0 Pain Relevance 0.40
Several disorders have been associated with mutations in Na,K-ATPase alpha isoforms (rapid-onset dystonia parkinsonism, familial hemiplegic migraine type-2), as well as reduction in Na,K-ATPase content (depression and Alzheimer's disease), thereby raising the issue of whether haploinsufficiency or altered enzymatic function contribute to disease etiology.
Negative_regulation (reduction) of Na,K-ATPase associated with parkinson's disease, depression, migraine with aura, migraine, dystonia and disease
4) Confidence 0.26 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17234593 Disease Relevance 0.73 Pain Relevance 0.18
In the Nakano mouse (cac mouse), which is well known as a hereditary cataract model, it has been reported that since its cataracts result from the inhibition of Na-K ATPase, swelling, disruption, and vacuolation of the fiber cells in the stellae lentis iridica and hyaloidea occur [6].
Negative_regulation (inhibition) of Na-K ATPase associated with pressure and volume under development and cataract
5) Confidence 0.02 Published 2008 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2292472 Disease Relevance 0.61 Pain Relevance 0
In short, we consider that the tissue abnormalities that we observed are similar to the abnormalities in cataracts resulting from the inhibition of Na-K ATPase, rather than to those in cataracts due to trauma.
Negative_regulation (inhibition) of Na-K ATPase associated with congenital anomalies, injury and cataract
6) Confidence 0.02 Published 2008 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2292472 Disease Relevance 1.01 Pain Relevance 0

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