INT61939

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Context Info
Confidence 0.06
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 4.82
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
PMN 4
lung 2
hearts 2
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 26 99.98 Very High Very High Very High
Inflammation 64 99.66 Very High Very High Very High
cva 2 99.06 Very High Very High Very High
adenocard 152 98.96 Very High Very High Very High
lidocaine 3 97.16 Very High Very High Very High
cINOD 2 90.96 High High
cytokine 8 86.24 High High
Inflammatory response 10 77.04 Quite High
ischemia 14 75.00 Quite High
Central nervous system 10 60.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 40 99.66 Very High Very High Very High
Contusions 2 99.32 Very High Very High Very High
Adult Respiratory Distress Syndrome 122 99.30 Very High Very High Very High
Hemorrhage 2 99.06 Very High Very High Very High
Adhesions 6 99.00 Very High Very High Very High
Injury 45 97.96 Very High Very High Very High
Reperfusion Injury 5 96.72 Very High Very High Very High
Hemorrhagic Shock 4 96.68 Very High Very High Very High
Lung Injury 16 95.44 Very High Very High Very High
Increased Venous Pressure Under Development 8 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, abciximab significantly reduced PMN accumulation in the ischemic myocardium from 38 +/- 1 PMNs/mm2 in untreated hearts to 7 +/- 1 in rats given abciximab.
Negative_regulation (reduced) of Positive_regulation (accumulation) of PMN in hearts
1) Confidence 0.06 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10599051 Disease Relevance 0.55 Pain Relevance 0.13
Treatment with an A2A agonist reduced PMN accumulation in the postischemic tissue and reduced infarct size.
Negative_regulation (reduced) of Positive_regulation (accumulation) of PMN associated with agonist
2) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.03 Pain Relevance 0.70
In a model of hemorrhage-induced ALI, pretreatment with an A2A agonist attenuated increases in both PMN sequestration into the lung and microvascular permeability.
Negative_regulation (attenuated) of Positive_regulation (increases) of PMN in lung associated with agonist, adult respiratory distress syndrome and cva
3) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.75 Pain Relevance 0.27
Lidocaine reduces PMN adhesion to endothelial surfaces in vivo, and inhibits upregulation of PMN-CD11b/CD18 (Mac-1) in vitro.
Negative_regulation (inhibits) of Positive_regulation (upregulation) of PMN associated with adhesions
4) Confidence 0.02 Published 1996 Journal Ann. Thorac. Surg. Section Abstract Doc Link 8619724 Disease Relevance 0.37 Pain Relevance 0.27
Adenosine is an endogenous anti-inflammatory metabolite that decreases PMN activation.
Negative_regulation (decreases) of Positive_regulation (activation) of PMN in PMN associated with adenocard and inflammation
5) Confidence 0.02 Published 2001 Journal Shock Section Abstract Doc Link 11386622 Disease Relevance 0.89 Pain Relevance 0.23
However, early suppression of PMN activation could worsen outcomes after penetrating abdominal trauma.
Negative_regulation (suppression) of Positive_regulation (activation) of PMN in PMN associated with injury
6) Confidence 0.02 Published 2001 Journal Shock Section Abstract Doc Link 11386622 Disease Relevance 1.23 Pain Relevance 0.22

General Comments

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