INT61939

Context Info Confidence 0.06 First Reported 1996 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 4.82 Pain Relevance 1.82

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce) cytoplasm (Tbce)

Anatomy Link Frequency PMN 4 lung 2 hearts 2 Tbce (Mus musculus)

Pain Link Frequency Relevance Heat agonist 26 99.98 Inflammation 64 99.66 cva 2 99.06 adenocard 152 98.96 lidocaine 3 97.16 cINOD 2 90.96 cytokine 8 86.24 Inflammatory response 10 77.04 ischemia 14 75.00 Central nervous system 10 60.32

Disease Link Frequency Relevance Heat INFLAMMATION 40 99.66 Contusions 2 99.32 Adult Respiratory Distress Syndrome 122 99.30 Hemorrhage 2 99.06 Adhesions 6 99.00 Injury 45 97.96 Reperfusion Injury 5 96.72 Hemorrhagic Shock 4 96.68 Lung Injury 16 95.44 Increased Venous Pressure Under Development 8 81.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, abciximab significantly reduced PMN accumulation in the ischemic myocardium from 38 +/- 1 PMNs/mm2 in untreated hearts to 7 +/- 1 in rats given abciximab.

Negative_regulation (reduced) of Positive_regulation (accumulation) of PMN in hearts

1) Confidence 0.06 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10599051 Disease Relevance 0.55 Pain Relevance 0.13

Treatment with an A2A agonist reduced PMN accumulation in the postischemic tissue and reduced infarct size.

Negative_regulation (reduced) of Positive_regulation (accumulation) of PMN associated with agonist

2) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.03 Pain Relevance 0.70

In a model of hemorrhage-induced ALI, pretreatment with an A2A agonist attenuated increases in both PMN sequestration into the lung and microvascular permeability.

Negative_regulation (attenuated) of Positive_regulation (increases) of PMN in lung associated with agonist, adult respiratory distress syndrome and cva

3) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.75 Pain Relevance 0.27

Lidocaine reduces PMN adhesion to endothelial surfaces in vivo, and inhibits upregulation of PMN-CD11b/CD18 (Mac-1) in vitro.

Negative_regulation (inhibits) of Positive_regulation (upregulation) of PMN associated with adhesions

4) Confidence 0.02 Published 1996 Journal Ann. Thorac. Surg. Section Abstract Doc Link 8619724 Disease Relevance 0.37 Pain Relevance 0.27

Adenosine is an endogenous anti-inflammatory metabolite that decreases PMN activation.

Negative_regulation (decreases) of Positive_regulation (activation) of PMN in PMN associated with adenocard and inflammation

5) Confidence 0.02 Published 2001 Journal Shock Section Abstract Doc Link 11386622 Disease Relevance 0.89 Pain Relevance 0.23

However, early suppression of PMN activation could worsen outcomes after penetrating abdominal trauma.

Negative_regulation (suppression) of Positive_regulation (activation) of PMN in PMN associated with injury

6) Confidence 0.02 Published 2001 Journal Shock Section Abstract Doc Link 11386622 Disease Relevance 1.23 Pain Relevance 0.22

General Comments

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