INT6194

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Context Info
Confidence 0.05
First Reported 1992
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.08
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
striatum 4
neurons 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
dexamethasone 8 99.96 Very High Very High Very High
Clonidine 2 84.80 Quite High
Enkephalin 8 84.16 Quite High
agonist 5 83.04 Quite High
Delta opioid receptors 2 55.52 Quite High
opioid receptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 1 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that dexamethasone (DM) modulates irANP secretion and pro-ANP mRNA expression from hypothalamic neurons in culture by switching the adrenoceptor responsiveness of the cells from alpha 2- to that of beta-AR.
Regulation (modulates) of Transcription (expression) of pro-ANP in neurons associated with dexamethasone
1) Confidence 0.05 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0.08 Pain Relevance 0.46
This study was designed to evaluate the effects of a chronic treatment with the classical neuroleptic drug haloperidol on the preproenkephalin (ppEnk) mRNA synthesis and its consequences for opioid and dopamine (DA) receptor-regulated adenylate cyclase in the developing and adult rat striatum.
Regulation (effects) of Transcription (synthesis) of cyclase in striatum associated with dopamine and opioid
2) Confidence 0.04 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.50
This study was designed to evaluate the effects of a chronic treatment with the classical neuroleptic drug haloperidol on the preproenkephalin (ppEnk) mRNA synthesis and its consequences for opioid and dopamine (DA) receptor-regulated adenylate cyclase in the developing and adult rat striatum.
Regulation (consequences) of Transcription (synthesis) of cyclase in striatum associated with dopamine and opioid
3) Confidence 0.04 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.50

General Comments

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