INT61945

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
monocyte 4
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2 100.00 Very High Very High Very High
lidocaine 3 97.28 Very High Very High Very High
cINOD 6 93.28 High High
COX-2 inhibitor 2 48.88 Quite Low
aspirin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Adhesions 5 99.00 Very High Very High Very High
Carcinoma 2 97.36 Very High Very High Very High
Reperfusion Injury 3 96.72 Very High Very High Very High
INFLAMMATION 2 92.72 High High
Cancer 10 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin-induced Mac-1 upregulation was prevented by a nitric oxide synthase inhibitor.
Negative_regulation (prevented) of Positive_regulation (upregulation) of Mac-1
1) Confidence 0.41 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Negative_regulation (down-regulated) of Positive_regulation (levels) of beta2-integrin in monocyte associated with chemokine, carcinoma and adhesions
2) Confidence 0.34 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Negative_regulation (down-regulated) of Positive_regulation (levels) of Mac-1 in monocyte associated with chemokine, carcinoma and adhesions
3) Confidence 0.34 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
Lidocaine reduces PMN adhesion to endothelial surfaces in vivo, and inhibits upregulation of PMN-CD11b/CD18 (Mac-1) in vitro.
Negative_regulation (inhibits) of Positive_regulation (upregulation) of CD18 associated with adhesions
4) Confidence 0.05 Published 1996 Journal Ann. Thorac. Surg. Section Abstract Doc Link 8619724 Disease Relevance 0.37 Pain Relevance 0.27

General Comments

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