INT61946

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 57
Total Number 58
Disease Relevance 38.93
Pain Relevance 11.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 34
Hepatocyte 6
fibroblasts 4
bowel 2
coronary artery 2
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 100.00 Very High Very High Very High
Angina 109 99.84 Very High Very High Very High
qutenza 10 99.84 Very High Very High Very High
ischemia 12 99.82 Very High Very High Very High
cINOD 14 99.04 Very High Very High Very High
aspirin 6 97.20 Very High Very High Very High
cytokine 8 95.68 Very High Very High Very High
Chronic pancreatitis 3 94.72 High High
antagonist 2 93.92 High High
Paracetamol 9 93.16 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 113 100.00 Very High Very High Very High
INFLAMMATION 45 100.00 Very High Very High Very High
Ulcers 12 100.00 Very High Very High Very High
Disease 188 99.96 Very High Very High Very High
Hepatitis 167 99.96 Very High Very High Very High
Chronic Hepatitis 156 99.84 Very High Very High Very High
Cv General 3 Under Development 75 99.84 Very High Very High Very High
Coronary Artery Disease 15 99.84 Very High Very High Very High
Acute Coronary Syndrome 2 99.84 Very High Very High Very High
Cv Unclassified Under Development 10 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with collaterals increased HGF plasma concentration was revealed.
Positive_regulation (increased) of HGF in HGF
1) Confidence 0.69 Published 2004 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 15559622 Disease Relevance 0.51 Pain Relevance 0.18
CONCLUSION: DEX inhibits restitution via HGF depletion, and rebamipide reverses the inhibited restitution by HGF induction.


Positive_regulation (induction) of HGF in HGF
2) Confidence 0.69 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925150 Disease Relevance 0 Pain Relevance 0
Elevated HGF levels were significantly more frequent than those of creatine kinase within 3 hours, and elevated levels correlated well with those of serum creatine kinase at 6-9 hours after onset of acute myocardial infarction.
Positive_regulation (Elevated) of HGF in HGF associated with myocardial infarction
3) Confidence 0.68 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8619866 Disease Relevance 0.82 Pain Relevance 0.25
Serum HGF was elevated within 3 hours in 8 of 10 patients (80%) with acute myocardial infarction after onset of chest pain (9.4 +/- 3.2 ng/mL, mean +/- SEM, values in normal subjects <0.39 ng/mL).
Positive_regulation (elevated) of HGF in chest associated with angina and myocardial infarction
4) Confidence 0.68 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8619866 Disease Relevance 0.71 Pain Relevance 0.19
Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction.
Positive_regulation (Increased) of hepatocyte growth factor in hepatocyte associated with myocardial infarction
5) Confidence 0.68 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8619866 Disease Relevance 0.83 Pain Relevance 0.24
No increase in serum HGF value was found in patients with angina pectoris or other heart diseases.
Neg (No) Positive_regulation (increase) of HGF in heart associated with angina and heart disease
6) Confidence 0.68 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8619866 Disease Relevance 0.82 Pain Relevance 0.25
Hepatocyte growth factor (HGF) is an angiogenic factor upregulated in ischaemic diseases.
Positive_regulation (upregulated) of HGF in Hepatocyte associated with disease
7) Confidence 0.65 Published 2003 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 16736998 Disease Relevance 1.14 Pain Relevance 0.89
Pts with SAP and UAP has significantly higher levels of HGF comparing with control group.
Positive_regulation (levels) of HGF in HGF associated with angina
8) Confidence 0.65 Published 2003 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 16736998 Disease Relevance 1.43 Pain Relevance 1.19
Symptomatic patients with inflammatory bowel diseases showed higher values of HGF than symptom-free patients (p < 0.05).
Positive_regulation (values) of HGF in bowel associated with inflammation
9) Confidence 0.64 Published 1997 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 9507565 Disease Relevance 1.24 Pain Relevance 0.23
There is a clear quantitative correlation between HGF protein and mRNA levels, as both HGF mRNA and protein levels are increased in CH, LDH, and CIRR.
Positive_regulation (increased) of HGF in HGF associated with chronic hepatitis and cirrhosis
10) Confidence 0.56 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.74 Pain Relevance 0.03
Serum HGF was elevated in acute coronary syndrome, indicating advanced endothelial cell damage.
Positive_regulation (elevated) of HGF in HGF associated with acute coronary syndrome
11) Confidence 0.56 Published 2000 Journal J Cardiol Section Abstract Doc Link 10834175 Disease Relevance 0.53 Pain Relevance 0.17
Patients with moderately severe or severe ulcerative colitis showed higher values of HGF than patients with mild disease (p < 0.05).
Positive_regulation (values) of HGF in HGF associated with inflammatory bowel disease and disease
12) Confidence 0.56 Published 1997 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 9507565 Disease Relevance 1.23 Pain Relevance 0.24
Thus, measurement of HGF is a sensitive method for early diagnosis of acute myocardial infarction.
Positive_regulation (measurement) of HGF in HGF associated with myocardial infarction
13) Confidence 0.49 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8619866 Disease Relevance 0.89 Pain Relevance 0.24
Hepatocyte growth factor (HGF) is a well-known powerful proliferative factor of vascular endothelial cells and it has been reported that plasma HGF concentrations are increased in acute myocardial infarction (AMI), although the mechanisms are not yet well delineated.
Positive_regulation (increased) of HGF in endothelial cells associated with myocardial infarction
14) Confidence 0.49 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 0.74 Pain Relevance 0.29
Heparin dramatically increased the HGF level and it declined to the normal range 18h after heparin injection.
Positive_regulation (increased) of HGF in HGF
15) Confidence 0.49 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 1.06 Pain Relevance 0.43
The study shows that serum HGF levels during the early stage of AMI increased significantly and peaked by day 7 after the onset, at which time there was a strong correlation with peak CRP levels.
Positive_regulation (increased) of HGF in HGF associated with myocardial infarction
16) Confidence 0.49 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 0.61 Pain Relevance 0.26
Even in the early stage (within 3 h of onset of symptoms to admission, average time was 1.8+/-0.1 h), serum HGF levels were already elevated (0.25+/-0.02 ng/ml, p<0.05).
Positive_regulation (elevated) of HGF in HGF
17) Confidence 0.49 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 1.07 Pain Relevance 0.46
Serum HGF levels on admission was significantly increased in UAP (mean+/-SE: 0.30+/-0.03ng/ml, p<0.01), and AMI (0.27+/-0.02ng/ml, p<0.01) compared with the normal subjects (0.19+/-0.01 ng/ml).
Positive_regulation (increased) of HGF in HGF associated with angina and myocardial infarction
18) Confidence 0.49 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 1.10 Pain Relevance 0.47
Clinical evaluation of hepatocyte growth factor in patients with gastrointestinal and pancreatic diseases with special reference to inflammatory bowel disease.
Positive_regulation (evaluation) of hepatocyte growth factor in bowel associated with inflammation and pancreatitis
19) Confidence 0.46 Published 1997 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 9507565 Disease Relevance 1.00 Pain Relevance 0.18
MATERIAL/METHODS: Fibroblasts were collected from normal peritoneum and were cultured with 5 ng/ml of TGF-beta1 along with increasing doses of HGF (10-40 ng/ml).
Positive_regulation (increasing) of HGF in HGF
20) Confidence 0.46 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20671605 Disease Relevance 0.09 Pain Relevance 0

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