INT61949

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 13
Speculated 5
Reported most in Abstract
Documents 74
Total Number 79
Disease Relevance 34.08
Pain Relevance 16.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 4
liver 3
paw 3
blood 2
kidney cortex 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 506 100.00 Very High Very High Very High
cytokine 158 100.00 Very High Very High Very High
Inflammatory mediators 28 100.00 Very High Very High Very High
antagonist 19 100.00 Very High Very High Very High
Inflammatory response 28 99.92 Very High Very High Very High
COX2 12 99.92 Very High Very High Very High
Paracetamol 71 99.90 Very High Very High Very High
cINOD 31 99.70 Very High Very High Very High
Clonidine 20 99.64 Very High Very High Very High
tetrodotoxin 2 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 563 100.00 Very High Very High Very High
Adenocarcinoma 27 99.72 Very High Very High Very High
Malignant Neoplastic Disease 4 99.66 Very High Very High Very High
Breast Cancer 4 99.56 Very High Very High Very High
Cardiomyopathy 2 99.56 Very High Very High Very High
Sepsis 27 99.54 Very High Very High Very High
Injury 51 99.32 Very High Very High Very High
Nociception 10 99.32 Very High Very High Very High
Diabetes Mellitus 796 99.20 Very High Very High Very High
Pain 61 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of inducible nitric oxide synthase (iNOS) activity, prostaglandin E(2) (PGE(2)), and metalloproteinase-3 (MMP-3) in experimentally induced inflammation of rat incisors dental pulp.
Spec (investigate) Regulation (regulation) of iNOS in dental pulp associated with inflammation and metalloproteinase
1) Confidence 0.58 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.26 Pain Relevance 0.22
To determine if fibroblasts are a source of NO inflammatory myocardial diseases, we have studied the effect of cytokines on the inducible NO synthase (iNOS) in neonatal cardiac fibroblasts and tested whether nonsteroidal anti-inflammatory drugs can diminish the induction of iNOS.
Regulation (effect) of iNOS in fibroblasts associated with cardiomyopathy, inflammation, cinod and cytokine
2) Confidence 0.55 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.46 Pain Relevance 0.26
Recently, PGE2 mediates up-regulation of iNOS in murine breast cancer cell line through EP4 receptors activation (26).
Regulation (regulation) of iNOS associated with breast cancer
3) Confidence 0.54 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.88 Pain Relevance 0.04
Ibuprofen: effect on inducible nitric oxide synthase.
Regulation (effect) of inducible nitric oxide synthase
4) Confidence 0.53 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9406924 Disease Relevance 0.19 Pain Relevance 0.35
Ketamine has hepatoprotective effects against LPS-induced liver injury that appear to be mediated, at least in part, by differential modulation of the oxidative stress proteins iNOS and HO-1.
Regulation (modulation) of iNOS in liver
5) Confidence 0.53 Published 2005 Journal J Trauma Section Body Doc Link 15824646 Disease Relevance 0.06 Pain Relevance 0
SC-58125 did not affect iNOS activity, whereas 1400W blocked iNOS activity.
Neg (not) Regulation (affect) of iNOS
6) Confidence 0.51 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16339820 Disease Relevance 0.07 Pain Relevance 0.17
The purpose of this study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of inducible nitric oxide synthase (iNOS) activity, prostaglandin E(2) (PGE(2)), and metalloproteinase-3 (MMP-3) in experimentally induced inflammation of rat incisors dental pulp.
Spec (investigate) Regulation (regulation) of inducible nitric oxide synthase in dental pulp associated with inflammation and metalloproteinase
7) Confidence 0.50 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.26 Pain Relevance 0.22
Salicylate did not affect iNOS enzymatic activity when added to the cytosolic lysate, although it was able to reduce enzymatic activity to 32% of induced levels when given to intact cells.
Neg (not) Regulation (affect) of iNOS
8) Confidence 0.48 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.34 Pain Relevance 0.43
Cannabidiol had no effect on neuronal and iNOS isoforms in injured sciatic nerve.
Neg (no) Regulation (effect) of iNOS in sciatic nerve associated with sciatic nerve
9) Confidence 0.48 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17157290 Disease Relevance 0.79 Pain Relevance 0.72
OBJECTIVES: The present study tests whether environmental stimuli paired with the administration of heroin alter the expression of inducible nitric oxide synthase (iNOS), one of the isoforms of the enzyme responsible for nitric oxide production.
Regulation (responsible) of iNOS
10) Confidence 0.45 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
NO synthesis was observed in neuronal soma, axons, and nerve endings of the myenteric plexus in the fundus of endotoxin-treated rats and was prevented by L-NAME, tetrodotoxin, and hexamethonium. nNOS and iNOS mRNA and protein contents were unchanged.
Regulation (unchanged) of iNOS in soma associated with tetrodotoxin
11) Confidence 0.44 Published 2004 Journal FASEB J. Section Abstract Doc Link 14715697 Disease Relevance 0.13 Pain Relevance 0.22
Furthermore, ketamine pretreatment significantly reduced the OVA-triggered up-regulation of iNOS and NO levels, especially in nebulized ketamine at 12.5 or 25 mg/ml or injected ketamine at dose of 50 ?
Regulation (regulation) of iNOS associated with ketamine
12) Confidence 0.44 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.34 Pain Relevance 0.42
OBJECTIVE AND DESIGN: The effect of a steroid and a non-steroid anti-inflammatory drug on the inducible nitric oxide synthase (NOS II) in rats suffering from lipopolysaccharide (LPS)-induced uveoretinitis was studied.
Regulation (effect) of NOS II associated with inflammation
13) Confidence 0.43 Published 2004 Journal Inflamm. Res. Section Abstract Doc Link 15167974 Disease Relevance 0.25 Pain Relevance 0.12
We determined the effects of cyclooxygenase-1 (COX-1; SC-560), COX-2 (SC-58125), and inducible nitric oxide synthase (iNOS; 1400W) inhibitors on atorvastatin (ATV)-induced myocardial protection and whether iNOS mediates the ATV-induced increases in COX-2.
Regulation (effects) of iNOS
14) Confidence 0.43 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16339820 Disease Relevance 0.06 Pain Relevance 0.18
However, the effects of anesthetics on organ function during sepsis and their influence on inflammatory mediators such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) remain to be fully elucidated.
Regulation (influence) of iNOS associated with inflammatory mediators and sepsis
15) Confidence 0.42 Published 2005 Journal Surgery Section Abstract Doc Link 16153419 Disease Relevance 0.72 Pain Relevance 0.38
Peritoneal macrophages, collected from healthy rats treated or not by lipopolysaccharides (LPS), together with commercially available iNOS from mouse macrophages (50 U, CALBIOCHEM, France Biochem, Meudon, France), were used as iNOS activity control.


Regulation (control) of iNOS in macrophages
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0 Pain Relevance 0.10
The most pronounced inhibition of hematopoesis, as well as granulopenia, thrombocytopenia, aplasia, and hemorrhage observed in 18 days pt are accompanied with the enhancedlevels of the NOS substrate and metabolites (L-arginine, RNS and L-citrulline) due to up-regulation of iNOS in marrow and blood formed elements (erythrocyte were not sudied).
Regulation (regulation) of iNOS in erythrocyte associated with thrombocytopenia, cva and aplasia
17) Confidence 0.40 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.38 Pain Relevance 0.05
In addition, the effects of the iNOS inhibitor L-NIL on inflammatory paw edema and thermal hyperalgesia were studied in comparison to those of the NO-donor RE-2047.
Regulation (effects) of iNOS in paw
18) Confidence 0.40 Published 2001 Journal Inflamm. Res. Section Body Doc Link 11289658 Disease Relevance 0.18 Pain Relevance 0
Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.
Regulation (effect) of iNOS in esophagus associated with adenocarcinoma
19) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.89 Pain Relevance 0.03
Effects of hyaluronan on carrageenan-induced synovitis in rat TMJ

Nitric oxide is one of many proinflammatory mediators that are involved in temporomandibular joint (TMJ) inflammatory disorder and is synthesized by inducible nitric oxide synthase (iNOS). iNOS is transcriptionally regulated by nuclear factor-?

Regulation (regulated) of iNOS in temporomandibular joint associated with snapping jaw, inflammation and synovitis
20) Confidence 0.39 Published 2010 Journal Anatomy & Cell Biology Section Title Doc Link PMC2998788 Disease Relevance 0.82 Pain Relevance 0.45

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