INT6195

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.00
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
neurons 3
BNP 3
striatum 1
brainstem 1
kidney 1
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 12 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
dexamethasone 32 99.36 Very High Very High Very High
Morphine 10 99.28 Very High Very High Very High
withdrawal 11 98.84 Very High Very High Very High
addiction 7 97.88 Very High Very High Very High
tolerance 3 97.28 Very High Very High Very High
Raphe magnus 3 97.08 Very High Very High Very High
medulla 1 96.20 Very High Very High Very High
Pain 9 94.84 High High
Disease Link Frequency Relevance Heat
Natriuresis 16 100.00 Very High Very High Very High
Pain 7 94.84 High High
Opiate Addiction 5 93.72 High High
INFLAMMATION 1 91.24 High High
Coronary Heart Disease 8 81.04 Quite High
Drug Dependence 2 79.44 Quite High
Fibrosis 4 76.44 Quite High
Low Back Pain 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of ANP and natriuretic peptide receptor-A (NPR-A) mRNA was determined in the kidney, as was that of endothelial NO synthase (NOS) proteins.
Spec (determined) Transcription (expression) of NPR-A in kidney associated with natriuresis
1) Confidence 0.69 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15053815 Disease Relevance 0.28 Pain Relevance 0.09
In this study, we demonstrate that withdrawal from chronic morphine significantly upregulates the mRNA level of adenylyl cyclase (AC) VI and VIII isoforms and immunoreactivity of ACV/VI in the nucleus raphe magnus (NRM), a brainstem site critically involved in opioid modulation of pain.
Transcription (level) of cyclase in brainstem associated with pain, medulla, raphe magnus, opioid, withdrawal and morphine
2) Confidence 0.62 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15829634 Disease Relevance 0.90 Pain Relevance 2.04
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Transcription (expression) of NPR in BNP
3) Confidence 0.52 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Transcription (expression) of NPR in BNP
4) Confidence 0.52 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
These immunoassay findings were accompanied by corresponding changes in the abundance of pro-ANP mRNA in the cultures as examined by colorimetric Northern blot analysis employing a 30 mer oligonucleotide probe corresponding to the first 10 amino acid sequence of rANP1-28.
Transcription (abundance) of pro-ANP
5) Confidence 0.09 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0 Pain Relevance 0.58
Here, we report that dexamethasone (DM) modulates irANP secretion and pro-ANP mRNA expression from hypothalamic neurons in culture by switching the adrenoceptor responsiveness of the cells from alpha 2- to that of beta-AR.
Transcription (expression) of pro-ANP in neurons associated with dexamethasone
6) Confidence 0.09 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0.08 Pain Relevance 0.46
We conclude from the above observations that glucocorticoids modulate irANP secretion and pro-ANP mRNA expression in hypothalamic neurons by altering the responsiveness of the cells from alpha 2-AR to that of beta-AR.
Transcription (expression) of pro-ANP in neurons
7) Confidence 0.09 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0 Pain Relevance 0.45
Plasticity of adrenoceptor responsiveness on irANP secretion and pro-ANP mRNA expression in hypothalamic neuron cultures: modulation by dexamethasone.
Transcription (expression) of pro-ANP in neuron associated with dexamethasone
8) Confidence 0.09 Published 1992 Journal Endocrinology Section Title Doc Link 1324165 Disease Relevance 0.10 Pain Relevance 0.41
Rather, brain-region-selective changes in adenylyl cyclase signal transduction are critical, and both these biochemical changes and the behavioral effects are prevented by facilitating endocytosis of the MOP receptor.
Transcription (transduction) of cyclase in brain
9) Confidence 0.08 Published 2007 Journal Pharmacology Section Abstract Doc Link 17356311 Disease Relevance 0 Pain Relevance 0.89
This study was designed to evaluate the effects of a chronic treatment with the classical neuroleptic drug haloperidol on the preproenkephalin (ppEnk) mRNA synthesis and its consequences for opioid and dopamine (DA) receptor-regulated adenylate cyclase in the developing and adult rat striatum.
Transcription (synthesis) of cyclase in striatum associated with dopamine and opioid
10) Confidence 0.07 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.50

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