INT61950

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 9.01
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
TMJ 4
neuronal 2
macrophage 2
medulla 2
glial cells 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 153 100.00 Very High Very High Very High
cytokine 18 100.00 Very High Very High Very High
Inflammatory mediators 8 100.00 Very High Very High Very High
Snapping jaw 54 99.20 Very High Very High Very High
medulla 13 98.44 Very High Very High Very High
cINOD 14 97.96 Very High Very High Very High
ketamine 8 97.68 Very High Very High Very High
anesthesia 9 96.96 Very High Very High Very High
Arthritis 8 96.64 Very High Very High Very High
Rostral ventrolateral medulla 55 95.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 175 100.00 Very High Very High Very High
Death 73 99.62 Very High Very High Very High
Cardiomyopathy 1 99.56 Very High Very High Very High
Sepsis 2 99.54 Very High Very High Very High
Temporomandibular Joint Syndrome 54 99.20 Very High Very High Very High
Urological Neuroanatomy 14 99.08 Very High Very High Very High
Chronic Fatigue Syndrome 11 98.64 Very High Very High Very High
Multiple Sclerosis 132 98.60 Very High Very High Very High
Stress 82 98.34 Very High Very High Very High
Arthritis 9 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE AND DESIGN: The effect of a steroid and a non-steroid anti-inflammatory drug on the inducible nitric oxide synthase (NOS II) in rats suffering from lipopolysaccharide (LPS)-induced uveoretinitis was studied.
Regulation (effect) of Positive_regulation (inducible) of NOS II associated with inflammation
1) Confidence 0.43 Published 2004 Journal Inflamm. Res. Section Abstract Doc Link 15167974 Disease Relevance 0.25 Pain Relevance 0.12
We determined the effects of cyclooxygenase-1 (COX-1; SC-560), COX-2 (SC-58125), and inducible nitric oxide synthase (iNOS; 1400W) inhibitors on atorvastatin (ATV)-induced myocardial protection and whether iNOS mediates the ATV-induced increases in COX-2.
Regulation (effects) of Positive_regulation (inducible) of iNOS
2) Confidence 0.43 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16339820 Disease Relevance 0.06 Pain Relevance 0.18
However, the effects of anesthetics on organ function during sepsis and their influence on inflammatory mediators such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) remain to be fully elucidated.
Regulation (influence) of Positive_regulation (inducible) of iNOS associated with inflammatory mediators and sepsis
3) Confidence 0.42 Published 2005 Journal Surgery Section Abstract Doc Link 16153419 Disease Relevance 0.72 Pain Relevance 0.38
To determine if fibroblasts are a source of NO inflammatory myocardial diseases, we have studied the effect of cytokines on the inducible NO synthase (iNOS) in neonatal cardiac fibroblasts and tested whether nonsteroidal anti-inflammatory drugs can diminish the induction of iNOS.
Regulation (effect) of Neg (NO) Positive_regulation (inducible) of iNOS in fibroblasts associated with cardiomyopathy, inflammation, cinod and cytokine
4) Confidence 0.40 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.46 Pain Relevance 0.26
We conclude that the spontaneous induction of iNOS in rat gastric tissue can affect the pharmacomechanical reactivity of the CM elements and that this regulation of the CM contractility is due to the induction of iNOS in a set of macrophage-related cells that are closely apposed to the CM elements so that they selectively affect only the contractility of the CM preparation.
Regulation (regulation) of Positive_regulation (induction) of iNOS in macrophage
5) Confidence 0.39 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374708 Disease Relevance 0 Pain Relevance 0.08
Ibuprofen: effect on inducible nitric oxide synthase.
Regulation (effect) of Positive_regulation (inducible) of inducible nitric oxide synthase
6) Confidence 0.39 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9406924 Disease Relevance 0.19 Pain Relevance 0.35
Furthermore, the volume of iNOS increases in the synovial membrane of rats after being exposed to mechanical stimulation, and iNOS is observed in the TMJ synovial membrane in cases of internal derangement and bone arthritis (Takahashi et al., 2003; Yamaza & Masuda, 2003).
Regulation (volume) of Positive_regulation (increases) of iNOS in TMJ associated with snapping jaw and arthritis
7) Confidence 0.39 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 1.12 Pain Relevance 0.89
Furthermore, the volume of iNOS increases in the synovial membrane of rats after being exposed to mechanical stimulation, and iNOS is observed in the TMJ synovial membrane in cases of internal derangement and bone arthritis (Takahashi et al., 2003; Yamaza & Masuda, 2003).
Regulation (volume) of Positive_regulation (increases) of iNOS in TMJ associated with snapping jaw and arthritis
8) Confidence 0.39 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 1.16 Pain Relevance 0.90
However, the effects of anesthetics on organ function during sepsis and their influence on inflammatory mediators such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) remain to be fully elucidated.
Regulation (influence) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with inflammatory mediators and sepsis
9) Confidence 0.37 Published 2005 Journal Surgery Section Abstract Doc Link 16153419 Disease Relevance 0.72 Pain Relevance 0.38
B is important for the induction of iNOS in glial cells [31], the effect of BW-B 70C on the activation of NF-?
Regulation (important) of Positive_regulation (induction) of iNOS in glial cells
10) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.26 Pain Relevance 0.06
DISCUSSION AND CONCLUSION: Ultrasound and phonophoresis treatments probably modulate and prevent the CFA-insult-induced increase in total and regional iNOS-LI neurons.
Regulation (modulate) of Positive_regulation (increase) of iNOS in neurons
11) Confidence 0.24 Published 2006 Journal Phys Ther Section Body Doc Link 16386061 Disease Relevance 0 Pain Relevance 0
Taken together, our results show a role for SK3 channels in iNOS induction and NO production by microglia, and in tyrosine nitration of neuronal proteins.
Regulation (role) of Positive_regulation (induction) of iNOS in neuronal
12) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.17 Pain Relevance 0
B plays a critical role in transcriptional regulation of the iNOS gene induced by various cytokines [39] NO regulates numerous physiological and pathophysiological processes, including smooth muscle contractility, platelet reactivity, and the cytotoxic activity of leukocytes.
Regulation (regulation) of Positive_regulation (induced) of iNOS in leukocytes associated with cytokine
13) Confidence 0.21 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.29 Pain Relevance 0.13
EAE and stress increase expression of iNOS (figure 6B: F: 26,53, dF: 7) and, although there is a trend toward the iNOS increase in expression to be higher in the EAE+S group, there are no statistical differences when compared to the EAE group.
Regulation (trend) of Positive_regulation (increase) of iNOS associated with stress and multiple sclerosis
14) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.45 Pain Relevance 0.21
The development of intestinal lesions induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of Positive_regulation (up) of iNOS associated with urological neuroanatomy
15) Confidence 0.11 Published 2010 Journal Clin. Chim. Acta Section Abstract Doc Link 20074562 Disease Relevance 0.39 Pain Relevance 0.29
Tyrosine phosphorylation regulates p38 MAPK activation [71] and iNOS induction [72], and LPS activates the p38?
Regulation (regulates) of Positive_regulation (induction) of iNOS
16) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.05 Pain Relevance 0
The development of intestinal lesions as induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of Positive_regulation (up) of iNOS associated with urological neuroanatomy
17) Confidence 0.09 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075458 Disease Relevance 0.39 Pain Relevance 0.21
This paper examines the role of the inducible enzymes cyclo-oxygenase (COX-2) and inducible NO synthase (iNOS) in the pathophysiology of CFS.
Spec (examines) Regulation (role) of Spec (examines) Positive_regulation (inducible) of inducible NO synthase associated with chronic fatigue syndrome
18) Confidence 0.04 Published 2007 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 17693978 Disease Relevance 0.96 Pain Relevance 0.09
Western blot analysis again revealed that microinjection bilaterally into RVLM of an effective dose of CGP57380 (5 pmol) significantly blunted the elevated NOS I or PKG protein level at ventrolateral medulla during the pro-life phase of experimental brain stem death (fig. 3), without affecting the increase of NOS II or nitrotyrosine protein expression (fig. 4).


Neg (without) Regulation (affecting) of Positive_regulation (increase) of NOS II in medulla associated with medulla, rostral ventrolateral medulla and death
19) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.37 Pain Relevance 0.35

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