INT61952

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 21
Disease Relevance 5.10
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
RAW 264 6
liver 5
spleen 5
macrophages 4
fibroblasts 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 99 100.00 Very High Very High Very High
aspirin 4 99.92 Very High Very High Very High
gABA 8 99.70 Very High Very High Very High
cINOD 12 98.86 Very High Very High Very High
Spinal cord 7 98.60 Very High Very High Very High
Inflammation 49 98.24 Very High Very High Very High
anesthesia 3 86.24 High High
cytokine 24 85.76 High High
Neurotransmitter 1 85.28 High High
ischemia 6 84.16 Quite High
Disease Link Frequency Relevance Heat
Arthritis 74 100.00 Very High Very High Very High
Heart Disease 1 98.58 Very High Very High Very High
INFLAMMATION 54 98.24 Very High Very High Very High
Death 6 94.68 High High
Apoptosis 2 93.92 High High
Infarction 2 92.92 High High
Wound Healing 3 91.84 High High
Injury 4 90.80 High High
Infection 9 88.04 High High
Disease 40 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1) markedly decreased iNOS mRNA expression in LPS-stimulated cells in a dose-dependent manner (Fig. 4).
Negative_regulation (decreased) of Transcription (expression) of iNOS
1) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0 Pain Relevance 0
The results suggest that WJL reduces LPS-induced NO production through the inhibition of iNOS mRNA expression, which leads to a decreased iNOS protein expression.
Negative_regulation (inhibition) of Transcription (expression) of iNOS
2) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.37 Pain Relevance 0.04
The initial study using rats showed that heroin administration (0, 0.01, 0.1, or 1.0 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS mRNA in spleen, lung, and liver tissue as measured by RT-PCR.
Negative_regulation (reduction) of Transcription (expression) of iNOS in liver
3) Confidence 0.43 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.17 Pain Relevance 0.14
RESULTS: The results showed that exposure to the conditioned stimulus produced a pronounced reduction in the expression of iNOS mRNA and protein in spleen, lung, and liver tissue.
Negative_regulation (reduction) of Transcription (expression) of iNOS in spleen
4) Confidence 0.43 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
Ibuprofen and other NSAIDs had no direct effect on catalytic activity of iNOS, but decreased levels of iNOS mRNA.
Negative_regulation (decreased) of Transcription (levels) of iNOS associated with cinod
5) Confidence 0.43 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.16 Pain Relevance 0.36
Ibuprofen concentration-dependently decreased iNOS mRNA levels, with an IC50 > 2 mM.
Negative_regulation (decreased) of Transcription (levels) of iNOS
6) Confidence 0.43 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.17 Pain Relevance 0.29
Consistent with these observations, the protein and mRNA expression levels of iNOS and COX-2 enzyme were markedly inhibited by ALA in a dose dependent manner.
Negative_regulation (inhibited) of Transcription (expression) of iNOS
7) Confidence 0.41 Published 2007 Journal Arch. Pharm. Res. Section Abstract Doc Link 17679548 Disease Relevance 0.63 Pain Relevance 0.35
Furthermore, there seems a dose related correlation between the inhibition of NO production and the inhibitions of iNOS mRNA and iNOS protein expressions by WJL in RAW 264.7 cells.
Negative_regulation (inhibitions) of Transcription (expressions) of iNOS in RAW 264
8) Confidence 0.40 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.19 Pain Relevance 0
As shown in the present study, WJL significantly inhibited NO production, as well as iNOS mRNA and protein expressions in LPS-stimulated RAW 264.7 cells.
Negative_regulation (inhibited) of Transcription (expressions) of iNOS in RAW 264
9) Confidence 0.40 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.21 Pain Relevance 0
These studies implicate cardiac fibroblasts as a source of NO in inflammatory cardiac diseases and suggest a possible therapeutic role for salicylate and aspirin in diminishing the steady state levels of iNOS mRNA.
Negative_regulation (diminishing) of Transcription (levels) of iNOS in fibroblasts associated with aspirin, inflammation and heart disease
10) Confidence 0.39 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.20 Pain Relevance 0.35
WJL also inhibited NO production and the expressions of inducible NO synthase (iNOS) mRNA and enzyme protein, determined by Griess reactions, RT-PCR or Western blotting respectively in Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages cells.
Negative_regulation (inhibited) of Transcription (expressions) of iNOS in macrophages
11) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2892354 Disease Relevance 0.13 Pain Relevance 0
Furthermore, it has been reported that oral feeding of B6 mice with the ethyl acetate extract of Tripterygium wilfordii Hook F (TWHF) or its active component, triptolide, led to the inhibition of both NO production and iNOS mRNA expression by macrophages [44], and this decrease in NO production was implicated in mediating the anti-inflammatory effects of TWHF.
Negative_regulation (inhibition) of Transcription (expression) of iNOS in macrophages associated with inflammation and arthritis
12) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206370 Disease Relevance 1.26 Pain Relevance 0.60
In addition, rosuvastatin inhibited iNOS mRNA and protein expression and increased eNOS mRNA and protein expression.
Negative_regulation (inhibited) of Transcription (expression) of iNOS
13) Confidence 0.28 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.75 Pain Relevance 0.48
This agent had no effect upon eNOS, but completely suppressed iNOS mRNA levels.
Negative_regulation (suppressed) of Transcription (levels) of iNOS
14) Confidence 0.26 Published 2000 Journal Inflamm. Res. Section Body Doc Link 11211925 Disease Relevance 0 Pain Relevance 0
Suppression of iNOS mRNA expression by R(-)- and S(+)-flurbiprofen was gene-specific in that both substances failed to inhibit LPS-induced COX-2 mRNA expression.
Negative_regulation (Suppression) of Transcription (expression) of iNOS
15) Confidence 0.26 Published 2001 Journal Pharm. Res. Section Body Doc Link 11405284 Disease Relevance 0 Pain Relevance 0
It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells.
Negative_regulation (inhibited) of Transcription (expression) of iNOS in RAW 264 associated with gaba
16) Confidence 0.23 Published 2007 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18156782 Disease Relevance 0.52 Pain Relevance 0.44
RESULTS: R(-)- and S(+)-flurbiprofen decreased LPS-induced iNOS mRNA and nitrite levels in an equipotent and concentration-dependent manner.
Negative_regulation (decreased) of Transcription (levels) of iNOS
17) Confidence 0.22 Published 2001 Journal Pharm. Res. Section Body Doc Link 11405284 Disease Relevance 0 Pain Relevance 0
The initial study using rats showed that heroin administration (0, 0.01, 0.1, or 1.0 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS mRNA in spleen, lung, and liver tissue as measured by RT-PCR.
Negative_regulation (reduction) of in spleen Transcription (expression) of iNOS in liver
18) Confidence 0.15 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.17 Pain Relevance 0.14
The initial study using rats showed that heroin administration (0, 0.01, 0.1, or 1.0 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS mRNA in spleen, lung, and liver tissue as measured by RT-PCR.
Negative_regulation (reduction) of in lung Transcription (expression) of iNOS in liver
19) Confidence 0.15 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.17 Pain Relevance 0.14
RESULTS: The results showed that exposure to the conditioned stimulus produced a pronounced reduction in the expression of iNOS mRNA and protein in spleen, lung, and liver tissue.
Negative_regulation (reduction) of in liver Transcription (expression) of iNOS in spleen
20) Confidence 0.15 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0

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