INT61953

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Context Info
Confidence 0.72
First Reported 1996
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 101
Total Number 102
Disease Relevance 46.64
Pain Relevance 25.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 6
lung 5
RAW 264 5
myocardium 3
plasma 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 31 100.00 Very High Very High Very High
pulpitis 14 100.00 Very High Very High Very High
Paracetamol 32 99.78 Very High Very High Very High
cytokine 97 99.72 Very High Very High Very High
Arthritis 141 99.68 Very High Very High Very High
Spinal cord 22 99.68 Very High Very High Very High
cva 26 99.48 Very High Very High Very High
aspirin 20 99.34 Very High Very High Very High
gABA 23 99.32 Very High Very High Very High
Inflammation 392 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 69 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Adhesions 20 100.00 Very High Very High Very High
Pulpitis 14 100.00 Very High Very High Very High
Cirrhosis 8 99.84 Very High Very High Very High
Arthritis 116 99.68 Very High Very High Very High
Sprains And Strains 66 99.50 Very High Very High Very High
Cv General 4 Under Development 23 99.48 Very High Very High Very High
Functional Bowel Disorder 16 99.42 Very High Very High Very High
Urological Neuroanatomy 14 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the time course of inducible NO synthase (iNOS) mRNA expression and the plasma TNF-alpha and IL-1beta in lipopolysaccharide (LPS)-treated conscious rats.
Transcription (expression) of iNOS in plasma
1) Confidence 0.72 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.37 Pain Relevance 0.12
In addition, the administration of BW attenuated the increase in iNOS mRNA expression and NO production in AA rats receiving indomethacin.
Transcription (expression) of iNOS associated with arthritis
2) Confidence 0.72 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19122291 Disease Relevance 0.91 Pain Relevance 0.44
The expression of the mRNA for inducible nitric oxide synthase (iNOS) mRNA expression and the production of nitric oxide (NO) in the gastric mucosa of AA rats were also increased by the administration of indomethacin.
Transcription (expression) of iNOS associated with arthritis
3) Confidence 0.72 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19122291 Disease Relevance 1.10 Pain Relevance 0.69
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Transcription (transcription) of iNOS
4) Confidence 0.72 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.56 Pain Relevance 0.23
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Transcription (activity) of inducible NO synthase
5) Confidence 0.69 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Transcription (activity) of iNOS
6) Confidence 0.69 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.56 Pain Relevance 0.24
OBJECTIVE: To study the relationship between endothelin-1(ET-1) and inducible nitric oxide synthase (iNOS) through the mRNA expression in pulpitis.
Transcription (expression) of iNOS associated with pulpitis
7) Confidence 0.69 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Abstract Doc Link 11776875 Disease Relevance 0.17 Pain Relevance 0.17
RESULTS: The mRNA expression of ET-1/iNOS in pulpitis groups was higher than the control.
Transcription (expression) of iNOS
8) Confidence 0.69 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11776875 Disease Relevance 0.09 Pain Relevance 0
No iNOS mRNA was detected either in the sham-operated animals, or at any of the other time intervals after SAH.
Transcription (detected) of iNOS mRNA associated with cva
9) Confidence 0.68 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9471107 Disease Relevance 0.67 Pain Relevance 0.46
Consistent with these observations, the protein and mRNA expression levels of iNOS and COX-2 enzyme were markedly inhibited by ALA in a dose dependent manner.
Transcription (expression) of iNOS
10) Confidence 0.67 Published 2007 Journal Arch. Pharm. Res. Section Abstract Doc Link 17679548 Disease Relevance 0.63 Pain Relevance 0.35
B can induce the expression of iNOS mRNA through NF-?
Transcription (expression) of iNOS
11) Confidence 0.67 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952320 Disease Relevance 1.07 Pain Relevance 0
As shown in the present study, WJL significantly inhibited NO production, as well as iNOS mRNA and protein expressions in LPS-stimulated RAW 264.7 cells.
Transcription (expressions) of iNOS in RAW 264
12) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.21 Pain Relevance 0
1) on iNOS mRNA expression in LPS-stimulated RAW 264.7 cells.
Transcription (expression) of iNOS in RAW 264
13) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0 Pain Relevance 0
The finding of strong radical scavenging activity by WJL led us to investigate further the biological significance of anti-oxidant of WJL by measuring NO production and iNOS mRNA and protein expressions in RAW 264.7 cells.
Neg (NO) Transcription (expressions) of iNOS in RAW 264
14) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.22 Pain Relevance 0
1) markedly decreased iNOS mRNA expression in LPS-stimulated cells in a dose-dependent manner (Fig. 4).
Transcription (expression) of iNOS
15) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0 Pain Relevance 0
In this study, we investigated the effects of WJ extracts on the inhibition of 1,1-Diphenyl-2-picryhydrazyl (DPPH) and NO formation in cell free system, as well as the expressions of iNOS mRNA and enzyme protein in RAW 264.7 murine macrophage cells.
Transcription (expressions) of iNOS in macrophage
16) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 1.01 Pain Relevance 0.12
The results suggest that WJL reduces LPS-induced NO production through the inhibition of iNOS mRNA expression, which leads to a decreased iNOS protein expression.
Transcription (expression) of iNOS
17) Confidence 0.66 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.37 Pain Relevance 0.04
In this study, we examined the time course of inducible NO synthase (iNOS) mRNA expression and the plasma TNF-alpha and IL-1beta in lipopolysaccharide (LPS)-treated conscious rats.
Transcription (expression) of inducible NO synthase in plasma
18) Confidence 0.63 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.37 Pain Relevance 0.12
The expression of the mRNA for inducible nitric oxide synthase (iNOS) mRNA expression and the production of nitric oxide (NO) in the gastric mucosa of AA rats were also increased by the administration of indomethacin.
Transcription (expression) of inducible nitric oxide synthase associated with arthritis
19) Confidence 0.63 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19122291 Disease Relevance 1.12 Pain Relevance 0.70
After LPS application, iNOS mRNA was first detected after 3 hrs, peaked at 6 hrs, and decreased thereafter. iNOS-positive cells were macrophages and neutrophils.
Transcription (detected) of iNOS in neutrophils
20) Confidence 0.63 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 16040737 Disease Relevance 0.59 Pain Relevance 0.60

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