INT6196

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2009
Negated 15
Speculated 11
Reported most in Abstract
Documents 83
Total Number 94
Disease Relevance 30.31
Pain Relevance 30.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 26
blood 4
ducts 3
pituitary 3
auricles 3
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 95 100.00 Very High Very High Very High
Morphine 81 100.00 Very High Very High Very High
anesthesia 41 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
opioid receptor 35 100.00 Very High Very High Very High
bradykinin 27 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
opiate 17 100.00 Very High Very High Very High
Intracerebroventricular 10 100.00 Very High Very High Very High
withdrawal 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 188 100.00 Very High Very High Very High
INFLAMMATION 31 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 26 100.00 Very High Very High Very High
Aging 2 100.00 Very High Very High Very High
Reprotox - General 1 16 99.84 Very High Very High Very High
Ocular Hypertension 7 99.84 Very High Very High Very High
Hypertension 67 99.68 Very High Very High Very High
Muscular Spasm 2 99.60 Very High Very High Very High
Pancreatitis 25 99.56 Very High Very High Very High
Diuresis 11 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous infusion of the same dose of clonidine or morphine did not affect plasma ANP levels.
Neg (not) Regulation (affect) of ANP in plasma associated with morphine and clonidine
1) Confidence 0.62 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2525782 Disease Relevance 0.15 Pain Relevance 1.04
We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles.
Spec (investigated) Regulation (influences) of atrial natriuretic peptide in auricles associated with natriuresis and morphine
2) Confidence 0.62 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.32
To investigate the impact of changes in the level of the endogenous atrial natriuretic factor (ANF) on pituitary-adrenocortical activity, the secretion of corticotropin (ACTH) and corticosterone was studied under the conditions of enhanced and decreased circulating ANF levels in rats.
Spec (investigate) Regulation (changes) of atrial natriuretic factor in pituitary associated with natriuresis
3) Confidence 0.62 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.10 Pain Relevance 0
To investigate the impact of changes in the level of the endogenous atrial natriuretic factor (ANF) on pituitary-adrenocortical activity, the secretion of corticotropin (ACTH) and corticosterone was studied under the conditions of enhanced and decreased circulating ANF levels in rats.
Spec (investigate) Regulation (changes) of ANF in pituitary associated with natriuresis
4) Confidence 0.62 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.10 Pain Relevance 0
Therefore, to clarify the role of glucose and/or feeding in this phenomenon, we used fasted, anesthetized rats to test how the ANP excretory response was affected by (1) short-term feeding before anesthesia, (2) 1 mL of isotonic glucose introduced into the stomach, and (3) the interaction of HOE-140 with these treatments.
Regulation (response) of ANP in stomach associated with anesthesia
5) Confidence 0.61 Published 1999 Journal Hypertension Section Abstract Doc Link 10523368 Disease Relevance 0.38 Pain Relevance 0.18
The effect of opiate ligand administration on plasma levels of atrial natriuretic peptide (ANP) was studied in awake, freely moving Sprague-Dawley rats.
Regulation (effect) of atrial natriuretic peptide in plasma associated with natriuresis and opiate
6) Confidence 0.61 Published 1988 Journal Life Sci. Section Abstract Doc Link 2901019 Disease Relevance 0.17 Pain Relevance 0.80
The effect of opiate ligand administration on plasma levels of atrial natriuretic peptide (ANP) was studied in awake, freely moving Sprague-Dawley rats.
Regulation (effect) of ANP in plasma associated with natriuresis and opiate
7) Confidence 0.61 Published 1988 Journal Life Sci. Section Abstract Doc Link 2901019 Disease Relevance 0.17 Pain Relevance 0.80
Naloxone had no effect on plasma renin activity (PRA), plasma atrial natriuretic peptide (ANP), or concentrations of Na+ and K+ in plasma.
Neg (no) Regulation (effect) of ANP in plasma associated with natriuresis and narcan
8) Confidence 0.60 Published 1991 Journal Clin Exp Hypertens A Section Abstract Doc Link 2022070 Disease Relevance 0.61 Pain Relevance 0.46
The effect of acute morphine treatment on plasma immunoreactive atrial natriuretic factor (IR-ANF) was studied in conscious non-hydrated rats.
Regulation (effect) of immunoreactive atrial natriuretic factor in plasma associated with natriuresis and morphine
9) Confidence 0.54 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2949987 Disease Relevance 0.10 Pain Relevance 0.50
The effect of multiple opioid receptor agonists on plasma immunoreactive atrial natriuretic factor (IR-ANF) was studied in conscious non-hydrated rats.
Regulation (effect) of immunoreactive atrial natriuretic factor in plasma associated with natriuresis, agonist and opioid receptor
10) Confidence 0.54 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.17 Pain Relevance 0.41
Effects of morphine and opioid peptides on plasma levels of atrial natriuretic peptide.
Regulation (Effects) of atrial natriuretic peptide in plasma associated with natriuresis, opioid and morphine
11) Confidence 0.53 Published 1988 Journal Life Sci. Section Title Doc Link 2901019 Disease Relevance 0.20 Pain Relevance 1.21
One microgram per kilogram i.v. of fentanyl had no effect on hemodynamic variables and plasma IR-ANP levels.
Neg (no) Regulation (effect) of IR-ANP in plasma
12) Confidence 0.53 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2143537 Disease Relevance 0.26 Pain Relevance 0.20
Basic ANP levels are not changed by high-dose fentanyl anaesthesia.
Neg (not) Regulation (changed) of ANP
13) Confidence 0.47 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1489072 Disease Relevance 0.39 Pain Relevance 0.07
The induction of high-dose fentanyl anaesthesia did not have an influence on plasmatic ANP levels.
Regulation (influence) of ANP
14) Confidence 0.47 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1489072 Disease Relevance 0.41 Pain Relevance 0.07
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Regulation (effect) of atrial natriuretic peptide associated with natriuresis
15) Confidence 0.45 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Regulation (effect) of ANP associated with natriuresis
16) Confidence 0.45 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
[Effects of microinjection of clonidine into nucleus tractus solitarii on atrial natriuretic factor in rats].
Regulation ([Effects) of atrial natriuretic factor in nucleus associated with natriuresis and clonidine
17) Confidence 0.45 Published 1991 Journal Sheng Li Xue Bao Section Title Doc Link 1836674 Disease Relevance 0.60 Pain Relevance 0.57
Effects of alpha 2-adrenergic receptors and calcium channel blockade on basal and clonidine-stimulated immunoreactive atrial natriuretic factor (IR-ANF) in conscious Sprague-Dawley rats were evaluated.
Regulation (Effects) of ANF associated with natriuresis, calcium channel and clonidine
18) Confidence 0.45 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.17 Pain Relevance 0.45
The effect of acute morphine treatment on plasma immunoreactive atrial natriuretic factor (IR-ANF) was studied in conscious non-hydrated rats.
Regulation (effect) of ANF in plasma associated with natriuresis and morphine
19) Confidence 0.45 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2949987 Disease Relevance 0.10 Pain Relevance 0.50
The effects of aging on the secretion of and renal sensitivity to atrial natriuretic factor (ANF) were studied concomitantly in both senescent (25- to 34-month-old) and in adult (7- to 13 month-old) female and male Long-Evans rats.
Regulation (effects) of ANF associated with natriuresis and aging
20) Confidence 0.45 Published 1996 Journal Gerontology Section Abstract Doc Link 9138977 Disease Relevance 0.33 Pain Relevance 0.13

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