INT61963

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gjd2) cell-cell signaling (Gjd2)
Anatomy Link Frequency
neurons 1
Gjd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 3 98.24 Very High Very High Very High
Gabapentin 7 97.86 Very High Very High Very High
anticonvulsant 2 75.00 Quite High
Calcium channel 1 75.00 Quite High
cerebral cortex 1 67.40 Quite High
Antiepileptic agent 1 62.92 Quite High
Dorsal horn 2 52.36 Quite High
Spinal cord 30 50.00 Quite Low
agonist 8 33.00 Quite Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 55 99.98 Very High Very High Very High
Decapitation 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sympathetic preganglionic neurons in the IML express the gap junction channel subunit connexin 36 (Cx36, Marina et al., 2008) and fire synchronous action potentials in slices as a result of electrotonic coupling (Logan et al., 1996).
Gene_expression (express) of Cx36 in neurons associated with action potential and urological neuroanatomy
1) Confidence 0.42 Published 2010 Journal Neuroscience Section Body Doc Link PMC2989444 Disease Relevance 0.39 Pain Relevance 0.08
Binding of [3H]gabapentin to COS-7 cells transfected with alpha2delta cDNA was elevated >10-fold over controls, consistent with the expression of alpha2 delta protein, as measured by Western blotting.
Gene_expression (expression) of alpha2 delta protein associated with gabapentin
2) Confidence 0.03 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8621444 Disease Relevance 0 Pain Relevance 0.72

General Comments

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