INT61967

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.46
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
spinal cord 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.92 Very High Very High Very High
Sciatic nerve 4 94.80 High High
Neuropathic pain 2 93.92 High High
anesthesia 2 93.84 High High
Hyperalgesia 2 91.88 High High
Inflammatory response 13 86.08 High High
cytokine 22 84.40 Quite High
Eae 7 83.52 Quite High
Inflammation 4 74.92 Quite High
fibrosis 23 74.24 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 95.92 Very High Very High Very High
Closed Head Injuries 4 95.28 Very High Very High Very High
Nervous System Injury 1 95.08 Very High Very High Very High
Hyperalgesia 2 91.88 High High
Gastroesophageal Reflux Disease 18 90.12 High High
Injury 13 86.76 High High
INFLAMMATION 18 85.72 High High
Fibrosis 15 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the protective effect by ghrelin in the spinal cord is mediated through the suppression of TNF-alpha and IL-1beta.
Positive_regulation (mediated) of Negative_regulation (suppression) of TNF-alpha in spinal cord associated with spinal cord
1) Confidence 0.50 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20561937 Disease Relevance 0.81 Pain Relevance 0.96
To this end, we used two pharmacological agents, each acting via a different mechanism: pentoxifylline (PTX), which attenuates the production of TNFalpha, and tumor necrosis factor binding protein (TBP), a physiological inhibitor of TNFalpha activity.
Positive_regulation (attenuates) of Negative_regulation (inhibitor) of TNFalpha associated with necrosis and cancer
2) Confidence 0.44 Published 1996 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 8621742 Disease Relevance 1.20 Pain Relevance 0.18
Normal saline controls also reveal that gastric fluid is not necessary to induce elevation of TNF-alpha levels (see figure 7).
Positive_regulation (induce) of Negative_regulation (elevation) of TNF-alpha
3) Confidence 0.32 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0.46 Pain Relevance 0.36

General Comments

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