INT61991

Context Info Confidence 0.59 First Reported 1996 Last Reported 1996 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.67 Pain Relevance 0.08

pigmentation (NF1) signal transduction (NF1) nucleus (NF1) intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)

NF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 81.92

Disease Link Frequency Relevance Heat Watson Syndrome 7 100.00 Neurofibroma 3 99.54 Infarction 1 97.60 Cancer 3 97.16 Hyperplasia 1 95.12 Neurofibrosarcoma 2 89.40 Pain 1 81.92 Malignant Neoplastic Disease 1 76.20 Plexiform Neurofibroma 1 75.56 Syndrome 1 64.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The molecular basis of neurofibroma development in NF1 is loss of expression of the NF1 gene and its gene product, neurofibromin, resulting in elevated levels of Ras-guanosine triphosphate.

Negative_regulation (loss) of Gene_expression (expression) of NF1 associated with watson syndrome and neurofibroma

1) Confidence 0.59 Published 1996 Journal J. Neurosurg. Section Abstract Doc Link 8622163 Disease Relevance 1.67 Pain Relevance 0.08

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