INT61992

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.47
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (NF1) signal transduction (NF1) nucleus (NF1)
intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)
Anatomy Link Frequency
thorax 2
Schwann cells 2
NF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 95.00 High High
epidural 1 91.12 High High
Pain 4 80.00 Quite High
Angina 1 63.52 Quite High
cva 2 58.36 Quite High
anesthesia 13 56.08 Quite High
Snapping jaw 20 50.88 Quite High
Inflammation 1 31.92 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Watson Syndrome 23 100.00 Very High Very High Very High
Neurofibroma 50 98.58 Very High Very High Very High
Hyperplasia 2 96.12 Very High Very High Very High
Infarction 1 95.68 Very High Very High Very High
Cancer 29 95.24 Very High Very High Very High
Scoliosis 1 89.84 High High
Coronary Heart Disease 1 88.48 High High
Neurofibrosarcoma 2 87.48 High High
Cicatrix 1 85.96 High High
Syndrome 4 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ak├žali et al. reports that they observed NF1 along with thorax deformity in one patient (rate 2.3%) out of 43 cases [16].
Positive_regulation (observed) of Gene_expression (observed) of NF1 in thorax associated with watson syndrome
1) Confidence 0.50 Published 2010 Journal Patient Saf Surg Section Body Doc Link PMC2904278 Disease Relevance 1.30 Pain Relevance 0.43
The molecular basis of neurofibroma development in NF1 is loss of expression of the NF1 gene and its gene product, neurofibromin, resulting in elevated levels of Ras-guanosine triphosphate.
Positive_regulation (resulting) of Gene_expression (product) of neurofibromin associated with watson syndrome and neurofibroma
2) Confidence 0.49 Published 1996 Journal J. Neurosurg. Section Abstract Doc Link 8622163 Disease Relevance 1.64 Pain Relevance 0.08
It has been suggested that the NF1 mutations produce abnormal neurofibromin, leading to increased levels of activating proteins (e.g., p21ras and p13) [29], which contribute to the cellular proliferation of Schwann cells associated with neurofibromas.
Positive_regulation (leading) of Gene_expression (produce) of neurofibromin in Schwann cells associated with neurofibroma and hyperplasia
3) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954971 Disease Relevance 1.53 Pain Relevance 0

General Comments

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