INT61999

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 15.40
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
Anatomy Link Frequency
neurons 2
neuronal 1
pyramidal neurons 1
brain 1
stem cells 1
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 60 99.84 Very High Very High Very High
Central nervous system 25 99.68 Very High Very High Very High
Arthritis 24 95.92 Very High Very High Very High
Hippocampus 64 95.84 Very High Very High Very High
Neuritis 1 89.20 High High
agonist 2 88.60 High High
Dopamine 41 88.28 High High
cocaine 4 83.76 Quite High
Neuropeptide 8 83.44 Quite High
Neurotransmitter 15 74.32 Quite High
Disease Link Frequency Relevance Heat
Tauopathy 147 100.00 Very High Very High Very High
Frontotemporal Dementia 117 100.00 Very High Very High Very High
Disease 912 99.20 Very High Very High Very High
Frailty 70 98.60 Very High Very High Very High
Parkinson's Disease 638 98.28 Very High Very High Very High
Disease Progression 18 97.96 Very High Very High Very High
Neurodegenerative Disease 99 97.36 Very High Very High Very High
Cognitive Disorder 99 97.08 Very High Very High Very High
Lewy Body Disease 16 96.16 Very High Very High Very High
Arthritis 24 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical characterization by western blotting revealed that 1 and 5 mM concentrations of TOCP significantly inhibited the expression of neurofilament high molecular weight protein (NF-H), and that 5 mM TOCP inhibited expression of microtubule-associated protein 2c and tau protein, but not beta-actin.
Gene_expression (expression) of tau
1) Confidence 0.75 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16909309 Disease Relevance 0.32 Pain Relevance 0.09
We next investigated whether beta gamma subunits play a role in the sensitization of type VI adenylyl cyclase activity; using expression of alpha tau to inhibit beta gamma-mediated effects, we found that the quinpirole-induced sensitization of type VI adenylyl cyclase was abolished.
Gene_expression (expression) of tau
2) Confidence 0.65 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8622641 Disease Relevance 0 Pain Relevance 0.15
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Gene_expression (levels) of Tau
3) Confidence 0.65 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.04 Pain Relevance 0.04
Tau-GFP expression as expected was ubiquitously present throughout the neurospheres (Figures 1(e) and 1(f)).
Gene_expression (present) of Tau
4) Confidence 0.65 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2821778 Disease Relevance 0 Pain Relevance 0
Tau protein expression, which is directly associated with estrogen expression, competes with tubulin-stabilizing agents for the same binding site and may confer resistance (Pusztai 2007).


Gene_expression (expression) of Tau
5) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.25 Pain Relevance 0
Tauopathies and mutations in Tau
Gene_expression (Tauopathies) of Tau associated with tauopathy
6) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.87 Pain Relevance 0.06
Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies

Tau aggregation is one of the major features in Alzheimer's disease and in several other tauopathies, including frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), and progressive supranuclear palsy (PSP).

Gene_expression (aggregation) of Tau in PSP associated with parkinson's disease, tauopathy, supranuclear palsy, frontotemporal dementia and disease
7) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Title Doc Link PMC2604894 Disease Relevance 0.88 Pain Relevance 0
AAV vectors to express EGFP, APP and Tau in pyramidal neurons in vivo
Gene_expression (express) of Tau in pyramidal neurons associated with pyramidal cell
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.71 Pain Relevance 0.15
Here we expressed Tau or APP, both wild-type and mutants, by adeno-associated viral vectors (AAV) injected directly into the hippocampus of wild-type mice.
Gene_expression (expressed) of Tau in hippocampus associated with hippocampus
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 1.75 Pain Relevance 0.05
Tau is abundantly expressed in the central nervous system, predominantly located in axons, and expression is also detectable in the axons of peripheral neurons.
Gene_expression (expressed) of Tau in peripheral neurons associated with central nervous system
10) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0 Pain Relevance 0.12
Neural stem cells were isolated from E15 embryos of timed pregnant mice expressing a Tau-GFP fusion protein [20] which were backcrossed to the C6BF1 mice used as hosts.
Gene_expression (expressing) of Tau in stem cells
11) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2821778 Disease Relevance 0.05 Pain Relevance 0.11
Fig. 2Longitudinal measurement of brain (A) and ventricular (B) volumes in five patients with MSTD and one asymptomatic mutation carrier.
Gene_expression (volumes) of MSTD in brain associated with frontotemporal dementia
12) Confidence 0.53 Published 2008 Journal Brain Section Body Doc Link PMC2702832 Disease Relevance 0.68 Pain Relevance 0
The MAPT produces a score from 0 (least disease severity) to 100 (greatest disease severity).

6.

Gene_expression (produces) of MAPT associated with disease
13) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693560 Disease Relevance 1.00 Pain Relevance 0.25
Two questions were addressed: first, whether chronic lithium treatment is able to prevent the formation of aberrant tau aggregates (formed by overexpression of FTDP-17 tau and GSK-3?)
Gene_expression (overexpression) of FTDP-17
14) Confidence 0.14 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.71 Pain Relevance 0
It has also been shown that MSTd neurons respond to dynamic roll-tilt (Chen et al. 2008).
Gene_expression (neurons) of MSTd in neurons
15) Confidence 0.08 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Recently, Liu and Angelaki (2009) have reported that MSTd neurons respond selectively to heading but not to changes in orientation with respect to gravity.
Gene_expression (neurons) of MSTd in neurons
16) Confidence 0.08 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
One of the explanations for this may be the significantly lower levels of t-tau and p-tau181 already present in incipient DLB [62], suggesting that the cognitive changes may well be influenced by additional factors, for example, neuronal cell loss, vascular insults, and so forth.


Gene_expression (levels) of t-tau in neuronal associated with parkinson's disease and cognitive disorder
17) Confidence 0.04 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.43 Pain Relevance 0
However, significant inverse correlation between t-tau levels and MMSE (r = ?
Gene_expression (levels) of t-tau
18) Confidence 0.04 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.68 Pain Relevance 0
Interestingly, CSF CART levels correlate with p-tau protein levels, but they do not appear to correlate with the DLB disease progression [71].
Gene_expression (levels) of p-tau associated with parkinson's disease and disease progression
19) Confidence 0.04 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.55 Pain Relevance 0.26
However, differences in CSF levels of p-tau, although significantly elevated in AD, failed to discriminate the disease entities within the Lewy body disease (LBD) spectrum, irrespective of presence of dementia (DLB, PDD, or PD).
Gene_expression (levels) of p-tau in body associated with parkinson's disease, dementia, lewy body disease and disease
20) Confidence 0.04 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 2.47 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox