INT62012

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 8.53
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Trafd1) molecular_function (Trafd1) cellular_component (Trafd1)
Anatomy Link Frequency
pancreas 3
brain 1
pineal gland 1
pancreatic ducts 1
vein 1
Trafd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 35 99.64 Very High Very High Very High
Hippocampus 7 98.80 Very High Very High Very High
Serotonin 2 98.76 Very High Very High Very High
Morphine 3 92.24 High High
Inflammation 23 91.56 High High
fortral 2 91.44 High High
GABAergic 6 75.00 Quite High
Calcium channel 2 72.12 Quite High
induced neuropathy 1 55.12 Quite High
metalloproteinase 13 52.00 Quite High
Disease Link Frequency Relevance Heat
Retinoblastoma 2 100.00 Very High Very High Very High
Malignant Neoplastic Disease 21 99.92 Very High Very High Very High
Cancer 59 99.64 Very High Very High Very High
Disease 23 99.00 Very High Very High Very High
Adenocarcinoma 14 99.00 Very High Very High Very High
Neointima 8 98.64 Very High Very High Very High
Diabetes Mellitus 12 96.12 Very High Very High Very High
Hyperglycemia 1 95.72 Very High Very High Very High
INFLAMMATION 31 92.28 High High
Adhesions 3 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of protein gene product 9.5, tyrosine hydroxylase and serotonin in the pineal gland of rats with streptozotocin-induced diabetes.
Gene_expression (Expression) of protein gene product in pineal gland associated with diabetes mellitus and serotonin
1) Confidence 0.31 Published 2008 Journal Neurosci. Res. Section Title Doc Link 18155792 Disease Relevance 0.60 Pain Relevance 0.14
In invasive ductal adenocarcinoma of the pancreas (n = 6), all cases showed strong expression of Tn and STn antigens and the MUC-1 gene product, but expressed no T antigen.
Gene_expression (expression) of MUC-1 gene product in pancreas associated with adenocarcinoma
2) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 1.05 Pain Relevance 0.41
The authors examined immunohistochemically the expression of these antigens and MUC-1 gene product in nine IPN.
Spec (examined) Gene_expression (expression) of MUC-1 gene product associated with ipn
3) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 0.73 Pain Relevance 0.25
In normal pancreas (n = 5), pancreatic ducts did not express T, Tn, or STn antigens, but expressed MUC-1 gene product.
Gene_expression (expressed) of MUC-1 gene product in pancreatic ducts
4) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 0.84 Pain Relevance 0.36
The expression of these antigens and MUC-1 gene product was focal in IPN, whereas it was diffuse in invasive ductal adenocarcinoma of the pancreas.
Gene_expression (expression) of MUC-1 gene product in pancreas associated with adenocarcinoma and ipn
5) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 1.07 Pain Relevance 0.43
Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas.
Gene_expression (Expression) of MUC-1 gene product in pancreas associated with cancer
6) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Title Doc Link 8623771 Disease Relevance 0.69 Pain Relevance 0.21
MUC-1 gene product was expressed in nine (100%) IPNs.
Gene_expression (expressed) of MUC-1 gene product
7) Confidence 0.18 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 0.99 Pain Relevance 0.38
Using a drug-conditioning paradigm, we examined the expression of the immediate early gene product, Fos, within specific brain circuits using immunocytochemical detection.
Spec (examined) Gene_expression (expression) of early gene product in brain
8) Confidence 0.17 Published 2000 Journal Synapse Section Abstract Doc Link 10881035 Disease Relevance 0 Pain Relevance 0.23
MUC-1 gene product (a mucin core protein of mammary type) is known to alter or overexpress in several malignant tumors.
Gene_expression (overexpress) of MUC-1 gene product associated with malignant neoplastic disease
9) Confidence 0.14 Published 1996 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 8623771 Disease Relevance 0.58 Pain Relevance 0.17
Brains were sectioned (100 mu m) and presence of the hsp7O gene protein product, HSP7O, was determined immunocytochemically. (+)-3-PPP significantly (0 <0.05) diminished the ability of rimcazole to inhibit PCP hsp7O induction in the retrosplenial cortex. (+)-Cyclazocine (15mg/kg, IP) and (+)-pentazocine (8Omg/kg, IP) given in an analogous manner did not diminish the ability of rimcazole to inhibit PCP hsp7O induction.
Gene_expression (presence) of hsp7O gene protein product in cortex associated with fortral
10) Confidence 0.10 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 9138745 Disease Relevance 0.14 Pain Relevance 0.22
Interestingly, cell cycle proteins, such as the transcription factor, E2F1, and its regulator, the retinoblastoma gene product, exhibit increased levels and altered expression patterns in Alzheimer’s Disease (AD), PD, and HAND postmortem tissue (Jordan-Sciutto et al. 2002a, b; Hoglinger et al. 2007).
Gene_expression (expression) of retinoblastoma gene product associated with disease and retinoblastoma
11) Confidence 0.01 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.80 Pain Relevance 0.04
In a rabbit model of vein grafting, Ad-mediated expression of a constitutively active form of the retinoblastoma gene product (Ad?
Gene_expression (expression) of gene product in vein associated with retinoblastoma
12) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.03 Pain Relevance 0.14
Nicotinic acetylcholine receptors containing the alpha7 gene product are expressed at substantial levels in the hippocampus.
Gene_expression (expressed) of alpha7 gene product in hippocampus associated with hippocampus
13) Confidence 0.01 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223543 Disease Relevance 0 Pain Relevance 0.16

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