INT62014

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.85
Pain Relevance 8.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
neuronal 1
spinal cord 1
neurons 1
urine 1
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 39 99.78 Very High Very High Very High
antagonist 42 99.32 Very High Very High Very High
qutenza 21 99.12 Very High Very High Very High
anticonvulsant 10 99.00 Very High Very High Very High
Spinal cord 181 98.80 Very High Very High Very High
Thermal hyperalgesia 120 98.60 Very High Very High Very High
Inflammatory mediators 46 98.56 Very High Very High Very High
allodynia 38 98.40 Very High Very High Very High
Pain 44 98.12 Very High Very High Very High
opiate 4 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 439 99.92 Very High Very High Very High
Hyperalgesia 274 98.60 Very High Very High Very High
Neuropathic Pain 217 98.40 Very High Very High Very High
INFLAMMATION 76 98.16 Very High Very High Very High
Pain 59 98.12 Very High Very High Very High
Hypercalcemia 1 95.00 High High
Contusions 24 94.04 High High
Bartter Syndrome 1 93.00 High High
Disease 6 92.24 High High
Malignant Neoplastic Disease 4 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of NKCC1 with its potent antagonist BU significantly reduced pain behavior in rats.
Negative_regulation (inhibition) of NKCC1 associated with pain and antagonist
1) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.16 Pain Relevance 1.03
Initially, both types of anesthesia similarly suppressed NKCC, with a peak effect 24 h after surgery.
Negative_regulation (suppressed) of NKCC associated with anesthesia
2) Confidence 0.43 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623949 Disease Relevance 0.25 Pain Relevance 0.58
The two types of anesthesia, however, differed in the rate of recovery of NKCC suppression.
Negative_regulation (suppression) of NKCC associated with anesthesia
3) Confidence 0.43 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623949 Disease Relevance 0.24 Pain Relevance 0.56
Inhibition of NKCC1 with its potent antagonist bumetanide reduces pain behavior in rats following SCI.
Negative_regulation (Inhibition) of NKCC1 associated with pain, spinal cord injury and antagonist
4) Confidence 0.41 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20536931 Disease Relevance 0.89 Pain Relevance 0.72
By the second postoperative day, NKCC returned to control values in the SDFA patients, whereas NKCC was still significantly suppressed after LDFA.
Negative_regulation (suppressed) of NKCC
5) Confidence 0.38 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623949 Disease Relevance 0.22 Pain Relevance 0.53
We have previously shown that large-dose fentanyl administration suppressed NKCC in rats.
Negative_regulation (suppressed) of NKCC
6) Confidence 0.38 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8623949 Disease Relevance 0.23 Pain Relevance 0.49
Inhibition of NKCC1 with its potent antagonist bumetanide (BU) had an anti-hyperalgesic effect in rats with chronic neuropathic pain following SCI.
Negative_regulation (Inhibition) of NKCC1 associated with hyperalgesia, spinal cord injury, antagonist and neuropathic pain
7) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.58 Pain Relevance 1.01
A low level of NKCC1 protein was expressed in the spinal cord tissue at baseline (Figure 2A). ?
Negative_regulation (level) of NKCC1 in spinal cord associated with spinal cord
8) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.07 Pain Relevance 0.38
Inhibition of NKCC1 with its potent antagonist BU significantly reduced pain behavior in rats.
Negative_regulation (Inhibition) of NKCC1 associated with pain and antagonist
9) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.35 Pain Relevance 0.71
As shown in Figure 4, a moderate reduction of NKCC1 occurred on days 21–35 post-SCI.
Negative_regulation (reduction) of NKCC1 associated with spinal cord injury
10) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.98 Pain Relevance 0.58
Inhibition of NKCC1 and TRPV1 attenuates capsaicin-induced allodynia [17].
Negative_regulation (Inhibition) of NKCC1 associated with allodynia and qutenza
11) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.16 Pain Relevance 1.14
Already after 1 hr, a significant rise of the p-NKCC1 signal (+18% ± 5.9%; p ?
Negative_regulation (rise) of p-NKCC1
12) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.37 Pain Relevance 0.19
Even if one doubts the specificity of DIOA and assumes that it also antagonized NKCC1 [35], this site of action could not account for the effect of DIOA we observed, unmasking low-threshold input to lamina I neurons, because blocking NKCC1 would work against exaggerated depolarization in primary afferents and thus prevent rather than produce cross talk between them as proposed for inflammatory insult [36].
Negative_regulation (blocking) of NKCC1 in neurons associated with inflammation
13) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2093929 Disease Relevance 0.44 Pain Relevance 0.32
Third, the blocker of cation-chloride co-transport used in the present study, DIOA, preferentially inhibits KCC2 and not NKCC1 [33,34].
Negative_regulation (inhibits) of NKCC1
14) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2093929 Disease Relevance 0.37 Pain Relevance 0.32
This was nicely demonstrated both in vitro and in vivo by Dzhala et al. who showed that bumetanide, an NKCC1 inhibitor, can suppress ictal activity in very young rats [65].
Negative_regulation (inhibitor) of NKCC1
15) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.41 Pain Relevance 0.26
Furosemide, a loop diuretic preferentially inhibiting KCC2 over NKCC1, has been shown to have anticonvulsant activity, but its effect has been linked to a decrease in neuronal synchronization and cell volume regulation [116].
Negative_regulation (inhibiting) of NKCC1 in neuronal associated with anticonvulsant
16) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.57 Pain Relevance 0.16
Consistent with this, we have previously demonstrated that downregulation of BSC-1 is associated with a marked reduction of urine concentration in several well characterized animal models, e.g., PTH-induced hypercalcemia (29) and low potassium diet-induced hypokalemia (30).
Negative_regulation (downregulation) of BSC-1 in urine associated with hypercalcemia and bartter syndrome
17) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.54 Pain Relevance 0

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