INT62029

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Context Info
Confidence 0.05
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
macrophage 2
cortex 2
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 64.60 Quite High
Inflammatory stimuli 2 55.20 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 94.76 High High
Disease 2 58.52 Quite High
INFLAMMATION 12 55.20 Quite High
Apoptosis 1 9.16 Low Low
Toxicity 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex.
Regulation (effect) of Localization (secretion) of APPS in cortex
1) Confidence 0.05 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 8624119 Disease Relevance 0.15 Pain Relevance 0.06
release from macrophage, as expected, but did not alter concurrent release of cathepsin B, this latter process resulting from a Ca++-dependent exocytosis of secretory lysosomes [60].
Neg (not) Regulation (alter) of Localization (release) of cathepsin B in macrophage
2) Confidence 0.01 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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