INT62031

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 10.39
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 5
memory B cell 3
bone marrow 2
lymphocytes 2
macrophages 1
Cd19 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 96 93.64 High High
Central nervous system 10 92.24 High High
Multiple sclerosis 91 87.88 High High
cytokine 229 84.76 Quite High
addiction 4 79.92 Quite High
chemokine 40 72.40 Quite High
cva 12 72.20 Quite High
headache 6 68.28 Quite High
Pain 7 67.76 Quite High
Adalimumab 17 64.96 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 147 99.82 Very High Very High Very High
Targeted Disruption 122 99.78 Very High Very High Very High
Infection 830 99.34 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 24 98.76 Very High Very High Very High
Chronic Lymphoid Leukemia 24 98.60 Very High Very High Very High
Hematological Disease 88 98.22 Very High Very High Very High
Genetic Translocation 2 98.08 Very High Very High Very High
Splenomegaly 27 97.44 Very High Very High Very High
Hypergammaglobulinemia 17 96.56 Very High Very High Very High
Hyperplasia 16 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasmablasts were defined as CD19low CD27high-expressing cells (Figure 1a).
Gene_expression (expressing) of CD19 in Plasmablasts
1) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.05 Pain Relevance 0.03
M.1- and WT virus–infected mice, CD19+ lung and splenic B cells were analyzed for markers of isotype-class switching (IgD?)
Gene_expression (lung) of CD19 in B cells
2) Confidence 0.56 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.17 Pain Relevance 0.11
The frequency of unsorted and CD19+ splenocytes recovered from I?
Gene_expression (unsorted) of CD19
3) Confidence 0.56 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.18 Pain Relevance 0
Cells were labeled with CD19 conjugated to PE, 5 ?
Gene_expression (labeled) of CD19
4) Confidence 0.56 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0 Pain Relevance 0
The frequency of latently infected CD19?
Gene_expression (infected) of CD19
5) Confidence 0.56 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.07 Pain Relevance 0.04
Our studies provide further evidence that the mouse infection with T. vivax causes a marked reduction in the spleen of both B220+CD19+IgM+/hiIgDlo (MZB) and B220+CD19+IgMlo/hiIgDhi follicular B cells.
Gene_expression (follicular B cells) of CD19 in follicular B cells associated with infection
6) Confidence 0.51 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.62 Pain Relevance 0
The cells retained CD19 and sIgG expression, suggesting differentiation to a pre-plasma memory B cell phenotype.
Gene_expression (expression) of CD19 in memory B cell
7) Confidence 0.46 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.29 Pain Relevance 0
However, after 10 days of infection, while more than 70% of B cells expressed IgM, immature pro-B progenitors (CD19+/loIgM?
Gene_expression (expressed) of CD19 in B cells associated with infection
8) Confidence 0.45 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.83 Pain Relevance 0
Altogether, these results suggest that the process of B cell hematopoiesis is disturbed in the bone marrow and may be instrumental in the subsequently diminishing production of mature B cells (CD19+IgM+CD43?)
Gene_expression (production) of CD19 in mature B cells associated with hematological disease
9) Confidence 0.45 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.78 Pain Relevance 0
Compared to bone marrow cells, NA-BMCs derived from Balb/c and C57Bl/6 showed a significant increase of CD11b+ and CD90+ and a significant decrease of cells expressing CD117+, CD117+/CD90low, T-cell and B-cell markers (CD4+, CD8+, CD19+) (Figure 1, shown for C57Bl/6 mice and Figure S2).
Gene_expression (expressing) of CD19 in B-cell
10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.43 Pain Relevance 0
For characterization of cell subsets, NA-BMCs and bone marrow cells were analyzed by flow cytometry for CD11b, CD117, CD4, CD8, CD19, CD31, CD90, CD117, and MHC-II expression in the CD45+ cell fraction.
Gene_expression (expression) of CD19 in bone marrow
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.43 Pain Relevance 0
In contrast, bone marrow cells expressed high levels of CD4+, CD8+, CD19+, and CD117+ cells and low levels of CD11b+ and CD90+ cells.
Gene_expression (levels) of CD19 in bone marrow
12) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.18 Pain Relevance 0.03
At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?
Gene_expression (transduction) of CD19 in B cells
13) Confidence 0.40 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Gene_expression (phenotype) of CD19 in memory B cell
14) Confidence 0.40 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0.05
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Gene_expression (sIgG+) of CD19 in memory B cell
15) Confidence 0.40 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0.05
Cells were analyzed for the expression of surface markers like Annexin V, CD34, CD38, Bcl-2, CD33, CD19 and CD3 (BD pharmingen- San Jose, California).
Spec (analyzed) Gene_expression (expression) of CD19
16) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.18 Pain Relevance 0.03
, yet retained surface expression of CD19 and IgG, and remained CD138low, indicating that they did not fully differentiated into plasma cells.
Gene_expression (expression) of CD19 in plasma cells
17) Confidence 0.36 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0.03
expression was maintained on CD3+ T cells, CD19+ B cells (Figure 1D), and macrophages (unpublished data) in smooth muscle cell–specific IL-4R?
Gene_expression (expression) of CD19 in macrophages
18) Confidence 0.32 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.34 Pain Relevance 0
A fraction of B lymphocytes (CD19+ lymphocytes) were also WASP-positive, amounting to 7% for patient 2 (Figure 1C, left and middle) and 4% for patient 1 (not shown).
Gene_expression (lymphocytes) of CD19 in lymphocytes
19) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0 Pain Relevance 0
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Neg (negative) Gene_expression (negative) of CD19 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
20) Confidence 0.29 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0

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