INT62042

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 67
Total Number 70
Disease Relevance 42.05
Pain Relevance 20.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 18
lymphocytes 6
macrophages 5
naive T cells 4
B cell 4
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1429 100.00 Very High Very High Very High
Inflammation 1267 100.00 Very High Very High Very High
rheumatoid arthritis 870 100.00 Very High Very High Very High
chemokine 186 100.00 Very High Very High Very High
Morphine 20 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
agonist 180 99.92 Very High Very High Very High
Dynorphin 1 99.80 Very High Very High Very High
Neuropeptide 13 99.76 Very High Very High Very High
mu opioid receptor 2 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 1595 100.00 Very High Very High Very High
INFLAMMATION 1426 100.00 Very High Very High Very High
Rheumatoid Arthritis 870 100.00 Very High Very High Very High
Disease 641 100.00 Very High Very High Very High
Cancer 323 100.00 Very High Very High Very High
Necrosis 64 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 36 100.00 Very High Very High Very High
Otitis Media 135 99.84 Very High Very High Very High
Adhesions 80 99.84 Very High Very High Very High
Influenza Virus Infection 39 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although IL-4 production by T cells from the peripheral blood of RA patients is increased compared with that of healthy controls, this Th2 activity seems to be insufficient to control Th1-associated inflammation in RA [11-13].
Positive_regulation (increased) of Gene_expression (production) of IL-4 in blood associated with inflammation and rheumatoid arthritis
1) Confidence 0.56 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.17 Pain Relevance 0.58
This is in contrast to (human) memory CD4+ T cells, which can produce IL-4 upon CD3 stimulation alone, but production is more pronounced when cultured in the presence of IL-4 [22].
Positive_regulation (stimulation) of Gene_expression (produce) of IL-4 in T cells
2) Confidence 0.56 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.23 Pain Relevance 0.15
During the last months of pregnancy Treg lymphocytes level is elevated leading to overexpression of IL-4 and IL-10.
Positive_regulation (leading) of Gene_expression (overexpression) of IL-4 in lymphocytes
3) Confidence 0.54 Published 2008 Journal Presse Med Section Abstract Doc Link 18819772 Disease Relevance 0.72 Pain Relevance 0.31
A U-shaped concentration response curve was observed for the effect of all agonists on IL-4 production 24 h after PHA activation.
Positive_regulation (activation) of Gene_expression (production) of IL-4 associated with agonist
4) Confidence 0.47 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.08 Pain Relevance 0.13
ASA inhibited IL-4, but not IL-2, promoter-driven chloramphenicol acetyltransferase expression in transiently transfected Jurkat T cells.
Positive_regulation (promoter-driven) of Gene_expression (expression) of IL-4 in T cells
5) Confidence 0.45 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.09 Pain Relevance 0.30
Neuropeptides accentuate interleukin-4 induced human immunoglobuline E synthesis in vitro.
Positive_regulation (induced) of Gene_expression (synthesis) of interleukin-4 associated with neuropeptide
6) Confidence 0.44 Published 1996 Journal Exp. Dermatol. Section Title Doc Link 8624610 Disease Relevance 0 Pain Relevance 0.35
Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro.
Positive_regulation (enhance) of Gene_expression (synthesis) of IL-4 in melanocyte
7) Confidence 0.41 Published 1996 Journal Exp. Dermatol. Section Abstract Doc Link 8624610 Disease Relevance 0 Pain Relevance 0.07
It has been shown in humans [22,23] and in mice [24,25] that, in an autocrine way, the initial endogenous IL-4 production, or IL-4 from other sources, can stimulate the development of IL-4-producing CD4+ T cells.
Positive_regulation (stimulate) of Gene_expression (production) of IL-4 in T cells
8) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.26 Pain Relevance 0.18
It has been shown in humans [22,23] and in mice [24,25] that, in an autocrine way, the initial endogenous IL-4 production, or IL-4 from other sources, can stimulate the development of IL-4-producing CD4+ T cells.
Positive_regulation (stimulate) of Gene_expression (production) of IL-4 in T cells
9) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.26 Pain Relevance 0.18
levels and additively enhanced IL-4 production (Fig. 2b).
Positive_regulation (enhanced) of Gene_expression (production) of IL-4
10) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.27 Pain Relevance 0.14
We show that interleukin-4 is transcriptionally induced in response to cannabinoids and that an interleukin-4 receptor antagonist blocks cannabinoid-dependent induction of mu-opioid receptors, indicating that induced expression of interleukin-4 is required in this process.
Positive_regulation (induced) of Gene_expression (expression) of interleukin-4 associated with antagonist, cannabinoid and mu opioid receptor
11) Confidence 0.39 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.80
production under these conditions, but it still enhanced IL-4 production.
Positive_regulation (enhanced) of Gene_expression (production) of IL-4
12) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.15 Pain Relevance 0.07
IL-7 added together with IL-4 resulted in a further increase of IL-4 production and a significantly decreased IFN-?
Positive_regulation (increase) of Gene_expression (production) of IL-4
13) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.21 Pain Relevance 0.10
IL-7 pretreatment had significantly sensitized the naive CD4+ T cells for increased IL-4 production compared with the control culture, whereas IFN-?
Positive_regulation (increased) of Gene_expression (production) of IL-4 in T cells
14) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.23 Pain Relevance 0.11
production and, in contrast to short-term culture, increased IL-4 production.
Positive_regulation (increased) of Gene_expression (production) of IL-4
15) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.21 Pain Relevance 0.10
In contrast to IL-7, addition of exogenous IL-4 during the primary stimulation had not primed T cells for increased IL-4 production, but had strongly suppressed IFN-?
Neg (not) Positive_regulation (increased) of Gene_expression (production) of IL-4 in T cells
16) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.26 Pain Relevance 0.13
During the last months of pregnancy Treg lymphocytes level is elevated leading to overexpression of IL-4 and IL-10.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-4 in lymphocytes
17) Confidence 0.36 Published 2008 Journal Presse Med Section Abstract Doc Link 18819772 Disease Relevance 0.72 Pain Relevance 0.31
PGE2 does not significantly increase IL-4 production in priming cultures, whereas it suppresses IL-2 and IFN-gamma.
Neg (not) Positive_regulation (increase) of Gene_expression (production) of IL-4
18) Confidence 0.33 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.74 Pain Relevance 0.52
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Positive_regulation (fashion) of Gene_expression (production) of IL-4 in naive T cells associated with necrosis and cancer
19) Confidence 0.33 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.80 Pain Relevance 0.55
Thus PGE2 does not act by increasing IL-4 production in priming cultures, and its effects are partly IL-4 independent and largely IL-2 independent.
Positive_regulation (increasing) of Gene_expression (production) of IL-4
20) Confidence 0.33 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.35 Pain Relevance 0.34

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