INT62044

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Context Info
Confidence 0.30
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 7.49
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
pores 2
neuronal 1
vasculature 1
liver 1
gastrocnemius 1
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 23 97.00 Very High Very High Very High
Multiple sclerosis 11 95.12 Very High Very High Very High
Inflammation 12 94.84 High High
cytokine 33 93.24 High High
Central nervous system 6 87.88 High High
unmyelinated 1 81.88 Quite High
qutenza 2 80.16 Quite High
withdrawal 7 78.40 Quite High
Neuritis 2 75.00 Quite High
Dorsal horn 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 4 100.00 Very High Very High Very High
Cerebral Malaria 30 98.40 Very High Very High Very High
Pain 23 97.00 Very High Very High Very High
Demyelinating Disease 11 95.12 Very High Very High Very High
INFLAMMATION 17 94.84 High High
Sprains And Strains 35 93.36 High High
Fatigue 58 92.96 High High
Urticaria 61 92.56 High High
Death 49 92.44 High High
Asthma 13 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In varying degrees, participants associated LT with health challenges, difficult procedures, lifestyle restrictions, and pain.
LT Binding (associated) of associated with pain
1) Confidence 0.30 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3024277 Disease Relevance 0.10 Pain Relevance 0.10
The heart was also recently suggested as a potential target of LT in rats [12],[51].
LT Binding (target) of in heart
2) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 1.09 Pain Relevance 0.06
Interactions were observed between the LT-DRP and that evoked from the sural or gastrocnemius nerves or motor cortex.
LT Binding (Interactions) of in gastrocnemius
3) Confidence 0.28 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307119 Disease Relevance 0 Pain Relevance 0.19
The data presented here provides the first direct evidence of profound LT-mediated effects on the heart and specifically on cardiac vasculature, presenting this organ as a key early target for LT function.
LT Binding (target) of in vasculature
4) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 1.13 Pain Relevance 0.06
Semi-structured qualitative interviews were conducted with children and adolescents who have undergone LT and their parents.
LT Binding (undergone) of
5) Confidence 0.23 Published 2010 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC3024277 Disease Relevance 0 Pain Relevance 0
Accordingly, finding effective ways to measure HRQOL and ultimately mitigate barriers and foster resilience, constitute important clinical and research priorities in the pursuit of HRQOL for LT recipients and their families.


LT Binding (recipients) of
6) Confidence 0.23 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3024277 Disease Relevance 0.22 Pain Relevance 0
Similar in proportion to the number of parent participants recognizing post LT gains in HRQOL, the majority of parents also identified worries concerning the health of their child, and many participants reported some form of medical complication in the first year post LT and/or medication side effects over time.
LT Binding (recognizing) of
7) Confidence 0.22 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3024277 Disease Relevance 0.07 Pain Relevance 0.07
However, the results for LT are surprising: Engwerda et al had pointed at the importance of LT, as C57BL/6 mice deficient for LT-?
LT Binding (deficient) of
8) Confidence 0.21 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.53 Pain Relevance 0.05
Few studies have investigated the physical fitness of liver transplant recipients, but the limited data available suggest a reduced physical fitness after LTx (Beyer et al. 1999; Stephenson et al. 2001; Unnithan et al. 2001).
LTx Binding (fitness) of in liver
9) Confidence 0.15 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC1914221 Disease Relevance 0.50 Pain Relevance 0
The production of E. coli heat labile toxin (LT) and cholera toxin (CT) and their binding to ganglioside monosialic acid (GM1) were studied by GM1-ELISA whereas the production and action of E. coli heat stable toxin (ST) was assessed by suckling mouse assay.


LT Binding (binding) of associated with vibrio infection
10) Confidence 0.13 Published 2010 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2911405 Disease Relevance 0.83 Pain Relevance 0.03
We describe the use of in situ hybridization with radiolabelled cDNA oligonucleotide probes to detect and enumerate TNF-alpha and LT mRNA expressing mononuclear cells without culture, and after culture in the presence of myelin basic protein (MBP), control antigens or without antigen.
LT Binding (enumerate) of in mononuclear cells
11) Confidence 0.09 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.09 Pain Relevance 0.38
Participants randomized to the OMT or LT groups received protocol treatments for 15 minutes, twice daily (?
LT Binding (randomized) of
12) Confidence 0.05 Published 2010 Journal Osteopath Med Prim Care Section Body Doc Link PMC2848182 Disease Relevance 0.49 Pain Relevance 0.04
These results suggested that ALOX5, which catalyzes the first step in the formation of LT, has a differing contribution in two major clinical pathogenesis related to ASA-sensitivity.
LT Binding (formation) of
13) Confidence 0.04 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779320 Disease Relevance 0.67 Pain Relevance 0
-LTX binding to the N-terminal fragment, and this correlates with signal transduction, which includes activation of G-protein and phospholipase C and subsequent release of Ca2+ from intracellular stores (Volynski et al., 2004).
LTX Binding (binding) of
14) Confidence 0.03 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.12 Pain Relevance 0
-LTX binds to not just one but three different classes of neuronal receptors, which (in order of their discovery) are neurexin I?
LTX Binding (binds) of in neuronal
15) Confidence 0.03 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0
-LTX seems to form pores and can conceivably lead to uncontrolled release from target cells.
LTX Binding (lead) of in pores
16) Confidence 0.02 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0
-LTX is the formation of membrane pores permeable to cations (Finkelstein et al., 1976), but this effect is negligible in tissues that lack ?
LTX Binding (formation) of in pores
17) Confidence 0.02 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.40 Pain Relevance 0.04
-LTX binding to receptor-expressing membranes, a significant proportion of toxin molecules became partially or fully protected against proteases (Khvotchev and Sudhof, 2000).
LTX Binding (binding) of
18) Confidence 0.02 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0
-LTX binding (Krasnoperov, V.G. et al., 2002) (Fig. 4D).
LTX Binding (binding) of
19) Confidence 0.02 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0.24 Pain Relevance 0

General Comments

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