INT62046

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.42
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
neuronal 2
cortex 1
CCO 1
mononuclear cells 1
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 11 99.54 Very High Very High Very High
qutenza 4 99.48 Very High Very High Very High
antagonist 2 99.28 Very High Very High Very High
Glutamate 4 99.04 Very High Very High Very High
Inflammation 7 98.20 Very High Very High Very High
unmyelinated 2 97.88 Very High Very High Very High
depression 12 96.82 Very High Very High Very High
Migraine 2 81.00 Quite High
cytokine 2 79.48 Quite High
Neuritis 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Fatigue 58 100.00 Very High Very High Very High
Demyelinating Disease 11 99.54 Very High Very High Very High
Neurological Disease 1 98.64 Very High Very High Very High
INFLAMMATION 5 98.20 Very High Very High Very High
Viral Meningitis 1 97.84 Very High Very High Very High
Depression 12 96.82 Very High Very High Very High
Stress 4 96.70 Very High Very High Very High
Pneumonia 29 83.52 Quite High
Toxicity 2 83.00 Quite High
Epilepsy 2 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IOSs show that the metabolic stress of SD combined with the compromise of energy resources leads to acute neuronal damage that is resistant to glutamate antagonists. (5) While hyperosmotic conditions reduce LT by causing cells to shrink, excitotoxic conditions reduce LT by causing dendritic beading.
Negative_regulation (reduce) of LT in neuronal associated with stress, glutamate, depression and antagonist
1) Confidence 0.43 Published 1999 Journal Methods Section Abstract Doc Link 10356350 Disease Relevance 0.87 Pain Relevance 0.42
IOSs show that the metabolic stress of SD combined with the compromise of energy resources leads to acute neuronal damage that is resistant to glutamate antagonists. (5) While hyperosmotic conditions reduce LT by causing cells to shrink, excitotoxic conditions reduce LT by causing dendritic beading.
Negative_regulation (reduce) of LT in neuronal associated with stress, glutamate, depression and antagonist
2) Confidence 0.43 Published 1999 Journal Methods Section Abstract Doc Link 10356350 Disease Relevance 0.80 Pain Relevance 0.41
The LT-DRP was unaffected by neonatal capsaicin treatment that destroyed most unmyelinated fibers.
Neg (unaffected) Negative_regulation (unaffected) of LT associated with qutenza and unmyelinated
3) Confidence 0.25 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307119 Disease Relevance 0.07 Pain Relevance 0.19
The LT-DRP was inhibited by preceding stimulation of the other three sources but LT stimulation did not inhibit DRPs evoked from sural or gastrocnemius nerves on the L6 dorsal root or from motor cortex on the L3 root.
Negative_regulation (inhibited) of LT in cortex
4) Confidence 0.25 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307119 Disease Relevance 0 Pain Relevance 0.22
This is illustrated by observations obtained from the present study wherein the extent of decrease of bacterial invasion with crude extract was greater than that with quercetin alone and the ability of the crude decoction (and not quercetin) to inhibit adherence and LT/CT.
Negative_regulation (inhibit) of LT
5) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2911405 Disease Relevance 0.19 Pain Relevance 0
Rehabilitation programs might be effective in reducing severity of fatigue after LTx, but, to develop appropriate programs, knowledge on the factors associated with fatigue after LTx is necessary.
Negative_regulation (reducing) of LTx associated with fatigue
6) Confidence 0.17 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC1914221 Disease Relevance 0.77 Pain Relevance 0
LT

The decrease in the production of LT by E. coli B831-2 (EC50 value 1.03% ± 0.32%) and its binding to GM1 (EC50 value 0.06% ± 0.02%) by the decoction was comparable to that of 2-mercaptoethanol (5 mM) and gallic acid (50 mM) respectively (Figure 6a).

Negative_regulation (decrease) of LT
7) Confidence 0.16 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2911405 Disease Relevance 0.14 Pain Relevance 0
Compared with patients with aseptic meningo-encephalitis, non-inflammatory neurological diseases and healthy controls, the multiple sclerosis patients had elevated numbers of TNF-alpha and LT mRNA expressing mononuclear cells in blood when enumerated without previous culture, and also after culture with MBP.
Negative_regulation (numbers) of LT in mononuclear cells associated with multiple sclerosis, neurological disease, inflammation and viral meningitis
8) Confidence 0.11 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.30 Pain Relevance 0.44
If the LT outcomes were the same as OMT and both were better than CCO, then the primary benefits of OMT could be attributed to the therapeutic effect of LT.
Negative_regulation (effect) of LT in CCO
9) Confidence 0.07 Published 2010 Journal Osteopath Med Prim Care Section Body Doc Link PMC2848182 Disease Relevance 0.29 Pain Relevance 0

General Comments

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