INT6205

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 5.48
Pain Relevance 10.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
neurons 3
plasma 2
caudate nucleus 1
substantia nigra 1
DA neurons 1
d1 (Dictyostelium discoideum)
Pain Term Frequency Confidence Heat
Enkephalin 15 100.00 Very High Very High Very High
Dopamine 52 100.00 Very High Very High Very High
dopamine receptor 10 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
nMDA receptor 24 99.98 Very High Very High Very High
primary somatosensory cortex 6 99.60 Very High Very High Very High
cocaine 20 99.16 Very High Very High Very High
Substantia nigra 4 98.66 Very High Very High Very High
Neuropeptide 14 98.52 Very High Very High Very High
imagery 1 98.50 Very High Very High Very High
Disease Term Frequency Confidence Heat
Disease 8 99.68 Very High Very High Very High
Stress 5 99.44 Very High Very High Very High
Abnormal Reflex 2 99.38 Very High Very High Very High
Overactive Bladder 4 99.10 Very High Very High Very High
Parkinson's Disease 47 97.34 Very High Very High Very High
Syndrome 6 97.16 Very High Very High Very High
Dyskinesias 20 95.72 Very High Very High Very High
Nociception 1 80.08 Quite High
Urological Neuroanatomy 2 76.16 Quite High
[[ /

[[]]]]

2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that blockade of dopamine re-uptake is sufficient to mimic the cocaine discriminative stimulus and suggest that stimulation of either D1 or D2 receptors is necessary but not sufficient for the expression of the discriminative stimulus effects of cocaine.
Positive_regulation (stimulation) of D1 associated with dopamine and cocaine
1) Confidence 0.69 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2195158 Disease Relevance 0 Pain Relevance 0.81
Stimulant reward apparently involves both D1 and D2 receptors; the data favour D2 mediation of stimulant drug reinforcement with a permissive or modulatory role for D1 receptors.
Positive_regulation (role) of D1
2) Confidence 0.42 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1324497 Disease Relevance 0 Pain Relevance 0.44
When switching from TOF to DBS, 3 stimulations (36 to 52 sec) were required for stabilization of the D1 response, and, finally, when switching from PTC to DBS, 5 to 11 stimulations (81 to 201 sec) were required for stabilization of the D1 response.
Positive_regulation (stabilization) of D1
3) Confidence 0.41 Published 1995 Journal J Clin Monit Section Abstract Doc Link 7595688 Disease Relevance 0 Pain Relevance 0.03
Although modulation of NMDA receptor functions by D1 receptor activation has been the subject of extensive investigation, little is known as to how the activation of NMDA receptors alters D1 function.
Positive_regulation (activation) of D1 associated with nmda receptor
4) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.44
Drugs designed to stimulate both dopamine D1 and D2 receptors in the brain may improve the therapy of Parkinson's disease.
Positive_regulation (stimulate) of D1 in brain associated with dopamine and disease
5) Confidence 0.36 Published 1989 Journal Mov. Disord. Section Abstract Doc Link 2571082 Disease Relevance 0.73 Pain Relevance 0.16
These results indicate that 1) the development of sensitization to amphetamine-induced effects on motor activity does not depend on the length of exposure to stress (acute or chronic). 2) the stimulation of both D1 and D2 dopaminergic receptors is necessary for the development of the restraint stress-induced sensitization to AMPH and 3) and opioid system is also implicated in this sensitization process.
Positive_regulation (stimulation) of D1 associated with stress and opioid
6) Confidence 0.28 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9264063 Disease Relevance 0.41 Pain Relevance 0.32
Stabilization of D1 was faster following TOF than following PTC (p < 0.01).
Positive_regulation (Stabilization) of D1
7) Confidence 0.28 Published 1995 Journal J Clin Monit Section Abstract Doc Link 7595688 Disease Relevance 0 Pain Relevance 0.03
In both cotransfected cells and cultured hippocampal neurons the activation of NMDA receptors increases the number of D1 receptors on the plasma membrane surface and enhances D1 receptor-mediated cAMP accumulation via a SNARE-dependent mechanism.
Positive_regulation (increases) of D1 in plasma associated with nmda receptor
8) Confidence 0.27 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.47
Our results demonstrate that the D1-NR1 physical interaction enables NMDA receptors to increase plasma membrane insertion of D1 receptors and provides a novel mechanism by which the activation of NMDA receptors upregulates D1 receptor function.
Positive_regulation (upregulates) of D1 in plasma associated with nmda receptor
9) Confidence 0.27 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.46
Experimental and clinical studies indicate that both dopamine D2-like and D1-like receptors are important in reversing the motor symptoms of Parkinson's disease, and therefore stimulation of both D1 and D2 receptors may be advantageous in its treatment.
Positive_regulation (stimulation) of D1 associated with dopamine and disease
10) Confidence 0.24 Published 1995 Journal Neurology Section Abstract Doc Link 7715795 Disease Relevance 0.56 Pain Relevance 0.20
When switching from TOF to DBS, 3 stimulations (36 to 52 sec) were required for stabilization of the D1 response, and, finally, when switching from PTC to DBS, 5 to 11 stimulations (81 to 201 sec) were required for stabilization of the D1 response.
Positive_regulation (stabilization) of D1
11) Confidence 0.24 Published 1995 Journal J Clin Monit Section Abstract Doc Link 7595688 Disease Relevance 0 Pain Relevance 0.04
Neuromagnetic source imaging of the topography of the functional organization of SI related to tactile stimulation of D1 and D5 showed that the source extent of the cortical representation of D5 increased during the illusion.
Positive_regulation (stimulation) of D1 associated with primary somatosensory cortex and imagery
12) Confidence 0.12 Published 2006 Journal Neuroimage Section Abstract Doc Link 16054839 Disease Relevance 0 Pain Relevance 0.34
Immunohistochemical methods revealed that the dopamine (DA) D1 and D2 receptor and methionine-enkephalin immunoreactivities (IRs) were increased in the putamen, and less significantly in the caudate nucleus.
Positive_regulation (increased) of D1 in caudate nucleus associated with dopamine and enkephalin
13) Confidence 0.07 Published 1999 Journal Neuropediatrics Section Abstract Doc Link 10401687 Disease Relevance 0.69 Pain Relevance 0.55
These results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine D1 receptors.
Positive_regulation (activation) of D1 in substantia nigra associated with parkinson's disease, dopamine, substantia nigra, abnormal reflex and overactive bladder
14) Confidence 0.07 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8098860 Disease Relevance 1.18 Pain Relevance 0.52
Moreover, dopamine D1 and D2 receptor mRNAs were significantly elevated in the rostral forebrain as were D1 and D2 receptor binding sites in days 60-70 cocaine-exposed fetuses.
Positive_regulation (elevated) of D1 in forebrain associated with dopamine and cocaine
15) Confidence 0.07 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668406 Disease Relevance 0 Pain Relevance 0.75
These results indicate that extracellular lactate levels may be a more suitable indicator of acute neural activation than glucose levels, and that simultaneous stimulation of D1 and D2 receptors enhances energy demands of DA neurons in the NAC.
Positive_regulation (stimulation) of D1 in DA neurons associated with nucleus accumbens and dopamine
16) Confidence 0.06 Published 2007 Journal Brain Res. Section Abstract Doc Link 17184754 Disease Relevance 0 Pain Relevance 0.65
These results suggest that expression of object pecking, but not necessarily drinker-directed activity, depends more on activation of D2 dopamine receptors than D1 receptors, the role of D3 and D4 receptors is less clear, and activation of mu and possibly kappa opioid receptors may play a contributory role.
Positive_regulation (activation) of D1 associated with dopamine receptor and kappa opioid receptor
17) Confidence 0.06 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029296 Disease Relevance 0.12 Pain Relevance 0.52
The activations of D1 or D2 receptor is unfavourable to the expression of EA after effect.
Positive_regulation (activations) of D1 associated with electroacupuncture
18) Confidence 0.06 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7834858 Disease Relevance 0 Pain Relevance 1.15
D1, but not D2, dopamine receptor agonists have previously been shown to increase Fos immunoreactivity in striatonigral neurons ipsilateral to a 6-hydroxydopamine lesion of the nigrostriatal pathway.
Positive_regulation (increase) of D1 in neurons associated with dopamine receptor and agonist
19) Confidence 0.05 Published 1992 Journal Neuroscience Section Abstract Doc Link 1359451 Disease Relevance 0 Pain Relevance 0.27
The present data suggest an opposite contribution of the dopamine D1 receptors (stimulatory) as compared with the dopamine D2 receptors (inhibitory) on PPE mRNA, whereas a similar stimulatory contribution of D1 or D2 receptors is observed for PPT mRNA.
Positive_regulation (contribution) of D1 associated with dopamine
20) Confidence 0.04 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930741 Disease Relevance 0.54 Pain Relevance 0.17

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