INT62054

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.83
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
mononuclear cells 3
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 33 99.38 Very High Very High Very High
Inflammation 3 91.84 High High
cytokine 6 89.12 High High
Opioid 5 86.92 High High
Hippocampus 2 84.20 Quite High
Endogenous opioid 1 79.64 Quite High
Neuritis 6 76.88 Quite High
Central nervous system 1 74.08 Quite High
Angina 2 73.68 Quite High
antagonist 1 65.68 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 33 99.38 Very High Very High Very High
Acute Coronary Syndrome 4 99.36 Very High Very High Very High
Viral Meningitis 3 93.28 High High
Necrosis 9 92.04 High High
INFLAMMATION 3 91.84 High High
Cancer 9 91.68 High High
Neurological Disease 3 90.80 High High
Optic Neuritis 6 77.36 Quite High
Myocardial Infarction 1 76.68 Quite High
Coronary Artery Disease 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confirmation experiments verified that stimulation with beta-endorphin increased the mRNA levels of myelin basic protein, glutathione S-transferase pi, c-junD and rab16 (P < 0.05), genes that are associated with oligodendrogenesis.
Transcription (levels) of myelin basic protein
1) Confidence 0.69 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16706836 Disease Relevance 0 Pain Relevance 0.49
Positive correlations were observed in multiple sclerosis between TNF-alpha and LT mRNA expressing blood mononuclear cells, MBP-reactive TNF-alpha and LT mRNA expressing cells, and TNF-alpha and interferon-gamma (INF-gamma) mRNA expressing mononuclear cells.
Transcription (expressing) of MBP-reactive in mononuclear cells associated with multiple sclerosis
2) Confidence 0.24 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.51 Pain Relevance 0.61
We describe the use of in situ hybridization with radiolabelled cDNA oligonucleotide probes to detect and enumerate TNF-alpha and LT mRNA expressing mononuclear cells without culture, and after culture in the presence of myelin basic protein (MBP), control antigens or without antigen.
Transcription (presence) of myelin basic protein in mononuclear cells
3) Confidence 0.24 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.18 Pain Relevance 0.40
We describe the use of in situ hybridization with radiolabelled cDNA oligonucleotide probes to detect and enumerate TNF-alpha and LT mRNA expressing mononuclear cells without culture, and after culture in the presence of myelin basic protein (MBP), control antigens or without antigen.
Transcription (presence) of MBP in mononuclear cells
4) Confidence 0.24 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.19 Pain Relevance 0.40
The highest specificity/sensitivity PAPP-A/proMBP levels for particular acute coronary syndrome (ACS) types were 10.65-14.75 mIU/l.
Transcription (levels) of proMBP associated with acute coronary syndrome
5) Confidence 0.00 Published 2008 Journal Physiol Res Section Abstract Doc Link 17223728 Disease Relevance 0.95 Pain Relevance 0.15

General Comments

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