INT62061

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 17.43
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Lung 3
dens 2
nucleus 1
dorsal horn 1
kidney 1
TRGC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 9 100.00 Very High Very High Very High
Dorsal horn 1 100.00 Very High Very High Very High
Neuropeptide 3 99.98 Very High Very High Very High
Migraine 6 99.52 Very High Very High Very High
headache 26 98.44 Very High Very High Very High
rheumatoid arthritis 23 98.20 Very High Very High Very High
bradykinin 123 96.12 Very High Very High Very High
depression 5 95.92 Very High Very High Very High
abdominal pain 40 93.00 High High
spinal inflammation 46 92.76 High High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 563 99.88 Very High Very High Very High
Disease 128 99.68 Very High Very High Very High
Headache 32 99.52 Very High Very High Very High
Pressure And Volume Under Development 223 99.42 Very High Very High Very High
Lung Cancer 464 99.18 Very High Very High Very High
Graft Vs Host Disease 12 98.52 Very High Very High Very High
Rheumatoid Arthritis 23 98.20 Very High Very High Very High
Cancer 71 97.16 Very High Very High Very High
Myalgia 5 96.44 Very High Very High Very High
Depression 8 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prophylaxis for HAE attacks is available; either with attenuated androgens which increase hepatic production of endogenous C1 inhibitor, or by antifibrinolytics such as tranexamic acid or ??
Gene_expression (production) of C1 associated with hereditary angioedema
1) Confidence 0.69 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 1.36 Pain Relevance 0.06
Approximately 85% of HAE cases are type 1, a deficiency in the amount of C1 inhibitor produced.
Gene_expression (produced) of C1 associated with hereditary angioedema
2) Confidence 0.67 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.99 Pain Relevance 0.12
Nearly all other cases are type 2 HAE, which is characterized by the expression of dysfunctional C1 inhibitor.
Gene_expression (expression) of C1 associated with hereditary angioedema
3) Confidence 0.67 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 1.01 Pain Relevance 0.12
Rhucin, a recombinant C1 inhibitor, given intravenously, is also currently unlicensed.52–54
Gene_expression (is) of C1
4) Confidence 0.59 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.80 Pain Relevance 0.12
While not being directly comparable, results of studies of C1 inhibitor in acute HAE suggest that the icatibant and C1 inhibitor are broadly similar in terms of onset of relief and time to complete resolution of symptoms.15–18,40
Gene_expression (icatibant) of C1 associated with hereditary angioedema
5) Confidence 0.59 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.48 Pain Relevance 0.07
Despite only recently gaining a licence in many EU countries and in the US, C1 inhibitor has been used extensively for HAE and has an impressive record.22,54,61,62 It seems likely that both C1 inhibitor and icatibant will be used, perhaps at different times in the same patient, according to circumstances.
Gene_expression (used) of C1 associated with hereditary angioedema
6) Confidence 0.59 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.33 Pain Relevance 0.07
However, people with HAE have C1 inhibitor levels <50% of normal, and they cannot produce C1 inhibitor fast enough to offset consumption in activated pathways[6].
Gene_expression (produce) of C1 associated with hereditary angioedema
7) Confidence 0.58 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.90 Pain Relevance 0.08
The C1 inhibitor CINRYZE™ (C1 esterase inhibitor [human]) was recently approved in the United States for routine prophylaxis in adults and adolescents.
Gene_expression (approved) of C1
8) Confidence 0.58 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.95 Pain Relevance 0.14
However, people with HAE have C1 inhibitor levels <50% of normal, and they cannot produce C1 inhibitor fast enough to offset consumption in activated pathways[6].
Gene_expression (produce) of C1 associated with hereditary angioedema
9) Confidence 0.50 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.96 Pain Relevance 0.08
We divided the high cervical fractures into four groups, including C1 fracture, C2 dens fracture, C2 hangman's fracture, and C1-2 associated fracture for this analysis.
Gene_expression (fracture) of C1 in dens
10) Confidence 0.34 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908866 Disease Relevance 0.13 Pain Relevance 0.06
Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2.
Gene_expression (expression) of C1 in nucleus associated with neuropeptide and spinal cord
11) Confidence 0.32 Published 2002 Journal Cephalalgia Section Title Doc Link 11972578 Disease Relevance 0.20 Pain Relevance 0.54
We divided the high cervical fractures into four groups, including C1 fracture, C2 dens fracture, C2 hangman's fracture, and C1-2 associated fracture for this analysis.
Gene_expression (fracture) of C1 in dens
12) Confidence 0.30 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908866 Disease Relevance 0.14 Pain Relevance 0.06
Lung cancer rates tend to be higher in places where C1 coal is produced.
Gene_expression (produced) of C1 in Lung associated with lung cancer
13) Confidence 0.30 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2610032 Disease Relevance 0.81 Pain Relevance 0
Lung cancer rates tend to be higher in places where the Late Permian C1 coal is produced.
Gene_expression (produced) of C1 in Lung associated with lung cancer
14) Confidence 0.30 Published 2008 Journal BMC Public Health Section Abstract Doc Link PMC2610032 Disease Relevance 0.80 Pain Relevance 0
All patients had normal C1-INH concentration and activity with respect to C1 esterase inhibition, ruling out both types of HAE (HAE type I and HAE type II).
Neg (inhibition) Gene_expression (inhibition) of C1 associated with hereditary angioedema
15) Confidence 0.28 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 1.28 Pain Relevance 0
The risk factor of interest is the use of C1 coal, which is producible in only a few places in the study area (Figure 4).
Gene_expression (producible) of C1
16) Confidence 0.26 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2610032 Disease Relevance 0.49 Pain Relevance 0
In those places where C1 coal is producible, production varies with time depending on the availability of alternative types of coal or wood.
Gene_expression (producible) of C1
17) Confidence 0.26 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2610032 Disease Relevance 0.38 Pain Relevance 0
Nanoquartz in Late Permian C1 coal and the high incidence of female lung cancer in the Pearl River Origin area: a retrospective cohort study

Background

Gene_expression (coal) of C1 in lung associated with lung cancer
18) Confidence 0.26 Published 2008 Journal BMC Public Health Section Title Doc Link PMC2610032 Disease Relevance 0.76 Pain Relevance 0
The sampling frame will be the 764 villages stratified by county (Xuan Wei, Fu Yuan, Qi Lin, and Zhan Yi) and the availability of producible C1 coal.
Gene_expression (producible) of C1
19) Confidence 0.26 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2610032 Disease Relevance 0.26 Pain Relevance 0
Computed tomography scan and endoscopy carried out during this attack revealed transient gastrointestinal wall edema which, along with decreased levels of serum C4 and C1 inhibitor, confirmed the diagnosis of HAE with gastrointestinal involvement.
Gene_expression (levels) of C1 associated with pressure and volume under development and hereditary angioedema
20) Confidence 0.22 Published 1999 Journal Endoscopy Section Abstract Doc Link 10376461 Disease Relevance 0.94 Pain Relevance 0.09

General Comments

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