INT62065

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Context Info
Confidence 0.14
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) intracellular (YY1) DNA binding (YY1)
chromosome organization (YY1) extracellular region (Penk) RNA binding (YY1)
YY1 (Homo sapiens)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
Potency 1 91.76 High High
Opioid 7 90.12 High High
opioid receptor 7 85.56 High High
Morphine 3 76.80 Quite High
Dynorphin 1 52.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SUPERFIT, a delta-selective irreversible ligand, decreased [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to delta receptors by approximately 75% and to mu receptors by approximately 50% in dimer cells.
delta Binding (binding) of enkephalin associated with enkephalin
1) Confidence 0.14 Published 2008 Journal Peptides Section Abstract Doc Link 18472184 Disease Relevance 0 Pain Relevance 0.79
In the receptor binding assay, both [Dmp(1)]DLT and [Dmp(1)]ENK bound to the delta-receptor with high affinity and selectivity, and were nearly as effective as the parent peptides.
delta Binding (bound) of ENK
2) Confidence 0.07 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14758045 Disease Relevance 0 Pain Relevance 0.49
The present study examines the receptor binding affinities of the POMC, ProEnk and ProDyn peptides to the cloned mu, delta and kappa receptors expressed transiently in transfected COS-1 cells.
delta Binding (affinities) of ProEnk
3) Confidence 0.01 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624732 Disease Relevance 0 Pain Relevance 0.42

General Comments

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