INT62067

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.24
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 8
cardiomyocytes 4
small intestine 2
kidney 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 15 84.12 Quite High
headache 3 66.48 Quite High
fibrosis 28 66.32 Quite High
anesthesia 1 61.92 Quite High
Angina 3 58.32 Quite High
Fibrositis 1 53.04 Quite High
cva 6 52.40 Quite High
cytokine 2 17.68 Low Low
backache 20 12.48 Low Low
antagonist 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 183 99.78 Very High Very High Very High
Bone Cancer 18 99.64 Very High Very High Very High
Hypercalcemia 68 98.40 Very High Very High Very High
Osteoporosis 134 98.00 Very High Very High Very High
Frailty 20 94.68 High High
Acid Base Imbalance 136 92.84 High High
Parathyroid Cancer 6 92.24 High High
Sunburn 2 89.96 High High
Disease 31 89.04 High High
Neointima 1 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Negative_regulation (downregulation) of Gene_expression (expression) of PTH
1) Confidence 0.41 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.35 Pain Relevance 0.11
Paricalcitol is a well tolerated and effective medication for reducing PTH levels in the CKD population while minimizing hypercalcemia and hyperphosphatemia.
Negative_regulation (reducing) of Gene_expression (levels) of PTH associated with chronic renal failure and hypercalcemia
2) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 1.72 Pain Relevance 0.03
After 8 weeks, rats in the PTH group received daily subcutaneous injections of PTH (60 ?
Negative_regulation (received) of Gene_expression (injections) of PTH
3) Confidence 0.37 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2765647 Disease Relevance 0.33 Pain Relevance 0.06
The reintroduction of cinacalcet led to another reduction in serum iPTH levels in all patients.
Negative_regulation (reduction) of Gene_expression (levels) of iPTH
4) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.18 Pain Relevance 0
The recommended healthful serum level is between 30 and 60 ng/mL. 25-Hydroxyvitamin D levels of >30 ng/mL are sufficient to suppress parathyroid hormone production and to maximize the efficiency of dietary calcium absorption from the small intestine.
Negative_regulation (suppress) of Gene_expression (production) of parathyroid hormone in small intestine
5) Confidence 0.21 Published 2007 Journal Nutr Clin Pract Section Abstract Doc Link 17507730 Disease Relevance 0.73 Pain Relevance 0.16
This was followed in the 1990s by in vitro experiments that demonstrated; an increased cytosolic calcium concentration in isolated rat myocytes in response to PTH [53], a reduced expression of PTH-related peptide receptor mRNA in rat hearts secondary to hyperparathyroidism due to chronic renal failure [54], and increased force and frequency of contraction of isolated, beating rat cardiomyocytes [51, 55].
Negative_regulation (reduced) of Gene_expression (expression) of PTH in cardiomyocytes associated with chronic renal failure and hypercalcemia
6) Confidence 0.20 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.81 Pain Relevance 0.03
There was a significant decrease in the serum PTH levels in the DD and DP groups, but no significant changes in weight or serum calcium.
Negative_regulation (decrease) of Gene_expression (levels) of PTH
7) Confidence 0.17 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0 Pain Relevance 0
This was followed in the 1990s by in vitro experiments that demonstrated; an increased cytosolic calcium concentration in isolated rat myocytes in response to PTH [53], a reduced expression of PTH-related peptide receptor mRNA in rat hearts secondary to hyperparathyroidism due to chronic renal failure [54], and increased force and frequency of contraction of isolated, beating rat cardiomyocytes [51, 55].
Negative_regulation (reduced) of Gene_expression (expression) of PTH in cardiomyocytes associated with chronic renal failure and hypercalcemia
8) Confidence 0.17 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.82 Pain Relevance 0.03
UNLABELLED: BACKGROUND and objective: The calcimimetic cinacalcet lowers blood para-thyroid hormone (PTH), calcium and phosphorus levels and calcium-phosphorus product in patients with chronic kidney disease receiving dialysis.
Negative_regulation (lowers) of Gene_expression (product) of PTH in kidney associated with chronic renal failure
9) Confidence 0.17 Published 2008 Journal Clin Drug Investig Section Abstract Doc Link 18783302 Disease Relevance 0.19 Pain Relevance 0
The bone disease of CKD is due to alterations in parathyroid hormone (PTH) levels, low vitamin D levels and, in some cases, the effects of certain toxins, such as aluminum [31].
Negative_regulation (alterations) of Gene_expression (levels) of PTH in parathyroid associated with chronic renal failure and bone cancer
10) Confidence 0.15 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.14 Pain Relevance 0
The bone disease of CKD is due to alterations in parathyroid hormone (PTH) levels, low vitamin D levels and, in some cases, the effects of certain toxins, such as aluminum [31].
Negative_regulation (alterations) of Gene_expression (levels) of parathyroid hormone in parathyroid associated with chronic renal failure and bone cancer
11) Confidence 0.15 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.14 Pain Relevance 0
This increase in BMD lead to a significant decreases in both vertebral fractures (65% and 69%) and nonvertebral fractures (53% and 54%) for the PTH groups respectively.
Negative_regulation (decreases) of Gene_expression (groups) of PTH
12) Confidence 0.14 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936264 Disease Relevance 0.05 Pain Relevance 0
Concerning calcium homeostasis, over 4 years, mild decreases in calcium and parathyroid hormone (PTH) serum levels were observed in the strontium ranelate group (from 2.38?
Negative_regulation (decreases) of Gene_expression (calcium) of PTH in parathyroid
13) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744775 Disease Relevance 0.38 Pain Relevance 0.09
Concerning calcium homeostasis, over 4 years, mild decreases in calcium and parathyroid hormone (PTH) serum levels were observed in the strontium ranelate group (from 2.38?
Negative_regulation (decreases) of Gene_expression (calcium) of parathyroid hormone in parathyroid
14) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744775 Disease Relevance 0.38 Pain Relevance 0.09

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