INT62068

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.20
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
cardiomyocytes 1
parathyroid 1
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 7 83.20 Quite High
fibrosis 22 66.32 Quite High
Angina 2 58.32 Quite High
antagonist 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Acute pain 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 93 98.40 Very High Very High Very High
Hypercalcemia 121 97.68 Very High Very High Very High
Renal Disease 18 97.48 Very High Very High Very High
Neointima 1 88.48 High High
Cancer 3 87.64 High High
Aseptic Necrosis Of Bone 1 86.04 High High
Hyperplasia 7 84.80 Quite High
Myalgia 1 83.20 Quite High
Fever 1 82.32 Quite High
Acute-phase Reaction 1 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under normal conditions, calcitriol regulates the expression of PTH by suppressing transcription of pre-pro-PTH messenger RNA (Russell et al 1986; Silver et al 1986).
Transcription (transcription) of PTH
1) Confidence 0.67 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.49 Pain Relevance 0
Like calcitriol, paricalcitol suppresses pre-pro-PTH mRNA synthesis and has a prolonged effect of PTH inhibition beyond its mean half-life of approximately 14 hours in hemodialysis patients (Cato et al 1998; Brandi et al 2002; Staniforth et al 2005).
Transcription (synthesis) of PTH
2) Confidence 0.67 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.17 Pain Relevance 0
In placebo-controlled studies, calcitriol (Slatopolsky et al 1984) and the three currently available vitamin D analogs, alfacalcidol (Hamdy et al 1995), doxercalciferol (Coburn et al 2004), and paricalcitol (Coyne et al 2006), all suppress PTH levels.
Transcription (suppress) of PTH
3) Confidence 0.65 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.59 Pain Relevance 0
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Transcription (expression) of PTH
4) Confidence 0.52 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.35 Pain Relevance 0.11
This was followed in the 1990s by in vitro experiments that demonstrated; an increased cytosolic calcium concentration in isolated rat myocytes in response to PTH [53], a reduced expression of PTH-related peptide receptor mRNA in rat hearts secondary to hyperparathyroidism due to chronic renal failure [54], and increased force and frequency of contraction of isolated, beating rat cardiomyocytes [51, 55].
Transcription (expression) of PTH in cardiomyocytes associated with chronic renal failure and hypercalcemia
5) Confidence 0.25 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.81 Pain Relevance 0.03
Peptides of the parathyroid hormone family
Transcription (Peptides) of parathyroid hormone in parathyroid
6) Confidence 0.20 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2613968 Disease Relevance 0.79 Pain Relevance 0.08

General Comments

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