INT62071

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 33
Disease Relevance 19.32
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
chondrocytes 6
basement membrane 4
osteoclasts 4
MDA-MB-231 4
bladder 2
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 51 100.00 Very High Very High Very High
cytokine 6 98.86 Very High Very High Very High
Inflammation 3 98.66 Very High Very High Very High
Angina 4 96.48 Very High Very High Very High
Pain 29 95.52 Very High Very High Very High
Mechanotransduction 168 84.24 Quite High
vincristine 1 69.64 Quite High
backache 1 61.28 Quite High
Somatostatin 1 50.56 Quite High
Eae 2 37.96 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 61 100.00 Very High Very High Very High
Lymphatic System Cancer 18 100.00 Very High Very High Very High
Hypercalcemia 147 99.90 Very High Very High Very High
Bone Cancer 126 98.84 Very High Very High Very High
INFLAMMATION 1 98.66 Very High Very High Very High
Cancer 974 98.44 Very High Very High Very High
Metastasis 487 98.36 Very High Very High Very High
Carcinoma 21 97.72 Very High Very High Very High
Cv General 3 Under Development 4 96.48 Very High Very High Very High
Breast Cancer 132 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicated that the hypercalcemia was due to production of PTHrP by the leukemic cells.
Positive_regulation (due) of Gene_expression (production) of PTHrP associated with hypercalcemia
1) Confidence 0.70 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 0.93 Pain Relevance 0.10
These data demonstrate that PTHrP gene expression in VSMCs markedly increases during neointimal formation, supporting the hypothesis that PTHrP may play an important role in vascular stenosis as a regulator of VSMC proliferation.
Positive_regulation (increases) of Gene_expression (expression) of PTHrP associated with pathologic constriction
2) Confidence 0.69 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.44 Pain Relevance 0.19
A constitutively active ER-alpha mutation (Tyr537Asn), identified from a human bone metastases, when it was expressed in human breast carcinoma cells, caused increased production of PTHrP.
Positive_regulation (caused) of Gene_expression (production) of PTHrP
3) Confidence 0.67 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.12 Pain Relevance 0
TGFbeta significantly enhanced the ER-alpha-mediated transcriptional activity induced by ER-alpha (Tyr537Asn), and this resulted in further stimulation of PTHrP production.
Positive_regulation (stimulation) of Gene_expression (production) of PTHrP
4) Confidence 0.67 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.10 Pain Relevance 0
A constitutively active ER-alpha mutation (Tyr537Asn), identified from a human bone metastases, when it was expressed in human breast carcinoma cells, caused increased production of PTHrP.
Positive_regulation (increased) of Gene_expression (production) of PTHrP
5) Confidence 0.67 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.12 Pain Relevance 0
High levels of inflammatory cytokines also potentiate the hypercalcaemic effect of PTHrP, and stimulate further PTHrP production.
Positive_regulation (stimulate) of Gene_expression (production) of PTHrP associated with inflammation and cytokine
6) Confidence 0.66 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.37 Pain Relevance 0.17
In the bone microenvironment, enhanced expression of PTHrP stimulates osteoclasts to resorb bone [4].
Positive_regulation (enhanced) of Gene_expression (expression) of PTHrP in osteoclasts
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.44 Pain Relevance 0.08
Our data show that the increased PTHrP expression induced by exogenous TGF-ß in vitro is mediated by the rigidity of the substrate on which the tumor cells are cultured.
Positive_regulation (increased) of Gene_expression (expression) of PTHrP associated with cancer
8) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.59 Pain Relevance 0.04
Our data show that the increased PTHrP expression induced by exogenous TGF-ß in vitro is mediated by the rigidity of the substrate on which the tumor cells are cultured.
Positive_regulation (mediated) of Gene_expression (expression) of PTHrP associated with cancer
9) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.60 Pain Relevance 0.04
As shown in Figure 4C, expression of PTHrP by MDA-4 cells seeded on 2 GPa substrates was upregulated relative to plasmid control (pc) cells and did not increase with increasing modulus.
Positive_regulation (upregulated) of Gene_expression (expression) of PTHrP
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.07
As shown in Figure 4C, expression of PTHrP by MDA-4 cells seeded on 2 GPa substrates was upregulated relative to plasmid control (pc) cells and did not increase with increasing modulus.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of PTHrP
11) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.05 Pain Relevance 0.07
As the bone is resorbed, the release of transforming growth factor beta (TGF-ß) from the bone matrix contributes to further increase PTHrP expression [5].
Positive_regulation (increase) of Gene_expression (expression) of PTHrP
12) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.44 Pain Relevance 0.08
In this study, we have shown that tumor cells respond to 2D substrates with rigidities comparable to that of bone by increasing expression and secretion of the osteolytic factor PTHrP.
Positive_regulation (increasing) of Gene_expression (expression) of PTHrP associated with cancer
13) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.61 Pain Relevance 0
Mechanical distension of the abdominal aorta [7], the uterus, and the bladder [8] in rats increased PTHrP expression by a factor of two or more.
Positive_regulation (increased) of Gene_expression (expression) of PTHrP in bladder
14) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.88 Pain Relevance 0
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Positive_regulation (increased) of Gene_expression (expression) of PTHrP
15) Confidence 0.50 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.23 Pain Relevance 0
Laboratory findings showed not only hypercalcemia, but also increased serum levels of PTHrP and a few of proinflammatory cytokines, such as TNF-alpha, and IL-6.
Positive_regulation (increased) of Gene_expression (levels) of PTHrP associated with hypercalcemia and cytokine
16) Confidence 0.43 Published 2007 Journal Rinsho Ketsueki Section Abstract Doc Link 17695305 Disease Relevance 0.55 Pain Relevance 0.24
Bone-like mechanical properties stimulate expression of PTHrP
Positive_regulation (stimulate) of Gene_expression (expression) of PTHrP
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.40 Pain Relevance 0
As shown in Figure 6, blocking ROCK either pharmacologically or genetically inhibits most of the incremental PTHrP expression resulting from treatment with exogenous TGF-ß.
Positive_regulation (incremental) of Gene_expression (expression) of PTHrP
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.42 Pain Relevance 0
MDA-MB-231 and RWGT2 cells showed 2.5-fold and 2-fold increases in PTHrP mRNA expression respectively in response to substrates with moduli exceeding 1 GPa compared to substrates with moduli <100 kPa (Figure 2A and B).
Positive_regulation (increases) of Gene_expression (expression) of PTHrP mRNA in MDA-MB-231
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.44 Pain Relevance 0
In this study, we have shown that tumor cells known to metastasize to bone respond to 2D substrates with rigidities comparable to that of the bone microenvironment by increasing expression and production of PTHrP.
Positive_regulation (increasing) of Gene_expression (production) of PTHrP associated with cancer
20) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.83 Pain Relevance 0

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