INT62072

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 4.45
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
cartilage 2
MDA-MB-231 2
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 51 100.00 Very High Very High Very High
Mechanotransduction 48 90.40 High High
Angina 2 58.32 Quite High
metalloproteinase 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 61 100.00 Very High Very High Very High
Osteolysis 18 99.80 Very High Very High Very High
Disease 16 99.20 Very High Very High Very High
Cancer 276 98.52 Very High Very High Very High
Metastasis 138 96.76 Very High Very High Very High
Breast Cancer 36 93.92 High High
Neointima 1 88.48 High High
Pathologic Constriction 2 75.00 Quite High
Hypertension 6 72.00 Quite High
Cardiovascular Disease 7 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Negative_regulation (downregulation) of Gene_expression (expression) of PTHrP
1) Confidence 0.43 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.35 Pain Relevance 0.11
Expression of PTHrP by MDA-KD4 cells seeded on the same substrates was down-regulated and did not increase with increasing substrate rigidity.
Neg (not) Negative_regulation (regulated) of Gene_expression (Expression) of PTHrP
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.06 Pain Relevance 0.07
Furthermore, inhibition of tumor cell actomyosin contractility in both pharmacological and genetic models decreased Gli2 and PTHrP expression.
Negative_regulation (decreased) of Gene_expression (expression) of PTHrP associated with cancer
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.99 Pain Relevance 0.03
Preclinical studies have indicated that inhibiting Gli2 activity reduces PTHrP expression and osteolysis [48].
Negative_regulation (reduces) of Gene_expression (expression) of PTHrP associated with osteolysis
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.52 Pain Relevance 0.03
As shown in Figure 6, blocking ROCK either pharmacologically or genetically inhibits most of the incremental PTHrP expression resulting from treatment with exogenous TGF-ß.
Negative_regulation (inhibits) of Gene_expression (expression) of PTHrP
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.43 Pain Relevance 0
Inhibition of actomyosin contractility by blebbistatin and inhibition of ROCK-I by Y-27632 induced a significant decrease in PTHrP mRNA expression in both MDA-MB-231 and RWGT2 cells (Figure 4B), suggesting that the upregulation of PTHrP on rigid substrates is mediated by ROCK.
Negative_regulation (decrease) of Gene_expression (expression) of PTHrP mRNA in MDA-MB-231
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.05 Pain Relevance 0.12
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
Negative_regulation (decreased) of Gene_expression (expression) of PTHrP
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.56 Pain Relevance 0
The expression of PTHrP in cartilage and OA was addressed in several studies.
Negative_regulation (addressed) of Gene_expression (expression) of PTHrP in cartilage associated with osteoarthritis
8) Confidence 0.14 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.50 Pain Relevance 0.49

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