INT62088

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.10
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 14 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
opioid receptor 26 98.60 Very High Very High Very High
Morphine 4 96.72 Very High Very High Very High
Kinase C 4 96.04 Very High Very High Very High
Opioid receptor 1 3 92.64 High High
antagonist 3 91.36 High High
narcan 2 90.48 High High
Opioid 1 82.00 Quite High
orphanin 5 81.72 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because phosphorylation of the mu receptor triggers the successive regulatory mechanisms responsible for desensitization, such as receptor uncoupling, internalization, and down-regulation, we investigated the ability of OFQ/N to modulate [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO)-induced mu receptor phosphorylation in BE(2)-C human neuroblastoma cells transfected with epitope-tagged mu receptors.
Regulation (modulate) of Phosphorylation (phosphorylation) of mu receptor associated with neuroblastoma and enkephalin
1) Confidence 0.35 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.10 Pain Relevance 0.65
The protein kinase inhibitor staurosporine blocked the effect of phorbol 12-myristate 13-acetate on mu receptor phosphorylation.
Regulation (effect) of Phosphorylation (phosphorylation) of mu receptor
2) Confidence 0.15 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626702 Disease Relevance 0 Pain Relevance 0.90
We have therefore determined the effect of PD98059 on agonist-induced mu-receptor phosphorylation.
Spec (determined) Regulation (effect) of Phosphorylation (phosphorylation) of mu-receptor associated with agonist
3) Confidence 0.02 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.67
U0126, another chemically unrelated inhibitor of the MAPK cascade, mimicked the effect of PD98059 on mu-receptor phosphorylation and desensitization.
Regulation (effect) of Phosphorylation (phosphorylation) of mu-receptor
4) Confidence 0.02 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.78

General Comments

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