INT62089

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Context Info
Confidence 0.63
First Reported 1996
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 0.62
Pain Relevance 10.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 45 100.00 Very High Very High Very High
Enkephalin 21 99.66 Very High Very High Very High
Kinase C 25 99.08 Very High Very High Very High
Morphine 13 98.74 Very High Very High Very High
opioid receptor 57 98.24 Very High Very High Very High
narcan 3 97.32 Very High Very High Very High
antagonist 10 96.96 Very High Very High Very High
Opioid receptor 1 12 94.32 High High
Opioid 10 90.84 High High
orphanin 35 90.56 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 7 99.28 Very High Very High Very High
Drug Dependence 1 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OFQ/N treatment (100 nM, 60 min) potentiated DAMGO-induced mu receptor phosphorylation; inhibition of GRK2 or protein kinase C concomitant with OFQ/N treatment blocked the OFQ/N-mediated increase in DAMGO-induced phosphorylation.
Phosphorylation (phosphorylation) of mu receptor associated with kinase c
1) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.10 Pain Relevance 0.63
Because phosphorylation of the mu receptor triggers the successive regulatory mechanisms responsible for desensitization, such as receptor uncoupling, internalization, and down-regulation, we investigated the ability of OFQ/N to modulate [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO)-induced mu receptor phosphorylation in BE(2)-C human neuroblastoma cells transfected with epitope-tagged mu receptors.
Spec (investigated) Phosphorylation (phosphorylation) of mu receptor associated with neuroblastoma and enkephalin
2) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.09 Pain Relevance 0.65
These data suggest that OFQ/N binds to NOP receptors and activates protein kinase C, which then increases the ability of GRK2 to phosphorylate the agonist-occupied mu receptor, heterologously regulating homologous mu receptor desensitization.
Phosphorylation (phosphorylate) of mu receptor associated with kinase c and agonist
3) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.06 Pain Relevance 0.41
However, DAMGO-induced mu receptor phosphorylation and OFQ/N-induced mu receptor desensitization occurred in cells expressing mu receptors lacking non-GRK phosphorylation sites.
Phosphorylation (phosphorylation) of mu receptor
4) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.07 Pain Relevance 0.44
Because phosphorylation of the mu receptor triggers the successive regulatory mechanisms responsible for desensitization, such as receptor uncoupling, internalization, and down-regulation, we investigated the ability of OFQ/N to modulate [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO)-induced mu receptor phosphorylation in BE(2)-C human neuroblastoma cells transfected with epitope-tagged mu receptors.
Phosphorylation (phosphorylation) of mu receptor associated with neuroblastoma and enkephalin
5) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.10 Pain Relevance 0.64
In addition, in cells expressing mu receptors in which the GRK-mediated phosphorylation site Ser(375) was mutated to alanine, OFQ/N treatment failed to potentiate DAMGO-induced mu receptor phosphorylation and failed to desensitize the mu receptor.
Phosphorylation (phosphorylation) of mu receptor
6) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.07 Pain Relevance 0.47
However, DAMGO-induced mu receptor phosphorylation and OFQ/N-induced mu receptor desensitization occurred in cells expressing mu receptors lacking non-GRK phosphorylation sites.
Phosphorylation (phosphorylation) of mu receptor
7) Confidence 0.48 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.07 Pain Relevance 0.41
These observations suggest that several biochemical pathways can lead to mu receptor phosphorylation events that may include mechanisms involved in mu receptor desensitization.
Phosphorylation (phosphorylation) of mu receptor
8) Confidence 0.27 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626702 Disease Relevance 0 Pain Relevance 0.67
The time course and dose-response relationships between mu receptor phosphorylation and agonist-induced desensitization display interesting parallels.
Phosphorylation (phosphorylation) of mu receptor associated with agonist
9) Confidence 0.27 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626702 Disease Relevance 0 Pain Relevance 0.96
These observations suggest that several biochemical pathways can lead to mu receptor phosphorylation events that may include mechanisms involved in mu receptor desensitization.
Phosphorylation (phosphorylation) of mu receptor
10) Confidence 0.27 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626702 Disease Relevance 0 Pain Relevance 0.66
The protein kinase inhibitor staurosporine blocked the effect of phorbol 12-myristate 13-acetate on mu receptor phosphorylation.
Phosphorylation (phosphorylation) of mu receptor
11) Confidence 0.27 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626702 Disease Relevance 0 Pain Relevance 0.88
We have therefore determined the effect of PD98059 on agonist-induced mu-receptor phosphorylation.
Phosphorylation (phosphorylation) of mu-receptor associated with agonist
12) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.66
PD98059 produced a dose-dependent inhibition of agonist-promoted mu-receptor phosphorylation with an IC50 of 20 microM.
Phosphorylation (phosphorylation) of mu-receptor associated with agonist
13) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.73
U0126, another chemically unrelated inhibitor of the MAPK cascade, mimicked the effect of PD98059 on mu-receptor phosphorylation and desensitization.
Phosphorylation (phosphorylation) of mu-receptor
14) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.77
Morphine appears to produce qualitatively and quantitatively different mu-receptor phosphorylation than other agonists, but the consequences of this remain obscure, at least in neurons.
Phosphorylation (phosphorylation) of mu-receptor in neurons associated with agonist and morphine
15) Confidence 0.01 Published 2005 Journal Neurosignals Section Abstract Doc Link 16772732 Disease Relevance 0.08 Pain Relevance 1.07

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