INT621

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 25
Disease Relevance 21.52
Pain Relevance 8.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1) response to stress (SERPINH1)
Anatomy Link Frequency
nails 2
hair 2
anterior 1
fingers 1
amniotic fluid 1
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 632 100.00 Very High Very High Very High
rheumatoid arthritis 467 100.00 Very High Very High Very High
Inflammation 318 99.74 Very High Very High Very High
psoriasis 198 99.64 Very High Very High Very High
metalloproteinase 36 98.30 Very High Very High Very High
cytokine 246 98.16 Very High Very High Very High
Pain 18 98.10 Very High Very High Very High
headache 3 97.44 Very High Very High Very High
methotrexate 61 94.32 High High
Infliximab 204 94.12 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 467 100.00 Very High Very High Very High
Seronegative Spondarthritis 446 100.00 Very High Very High Very High
Arthritis 174 100.00 Very High Very High Very High
Experimental Arthritis 52 100.00 Very High Very High Very High
Oligohydramnios 5 99.96 Very High Very High Very High
Infection 83 99.90 Very High Very High Very High
Premature Birth 204 99.80 Very High Very High Very High
Pre-term Labor 60 99.80 Very High Very High Very High
INFLAMMATION 316 99.74 Very High Very High Very High
Psoriasis 224 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, vaginal bleeding, oligohydramnios, PPROM and, to a lesser extent, threatened preterm labour were significantly increased in both spontaneous and elective preterm deliveries.


Positive_regulation (increased) of PPROM associated with oligohydramnios and reprotox - general 1
1) Confidence 0.57 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2877057 Disease Relevance 1.27 Pain Relevance 0
MMPs 1-3, 8, 9 and 14 are upregulated in the amnion and chorion and their concentrations increased in amniotic fluid in PPROM [67].
Positive_regulation (increased) of PPROM in amniotic fluid associated with metalloproteinase
2) Confidence 0.22 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.77 Pain Relevance 0.41
Based on those previous findings and our results, we suggest that the use of KCl for MFPR may cause or aggravate the inflammatory process and induce PPROM and preterm birth.
Positive_regulation (induce) of PPROM associated with inflammation and premature birth
3) Confidence 0.21 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526504 Disease Relevance 0.52 Pain Relevance 0.17
In this report, we present a rare case of a 52-year-old man with a unique form of hypertrophic pachymeningitis involving the anterior part of the falx and who was positive for rheumatoid factor.
Positive_regulation (positive) of rheumatoid factor in anterior associated with meningitis
4) Confidence 0.21 Published 2005 Journal Rheumatol. Int. Section Abstract Doc Link 15660236 Disease Relevance 0.46 Pain Relevance 0.18
Although no study has been conducted on the roles of KCl in relation to matrix degrading enzyme activity in the intrauterine system, we hypothesize that KCl can cause PPROM by inducing matrix degrading enzymes in the uterus after MFPR.
Positive_regulation (cause) of PPROM in uterus
5) Confidence 0.15 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526504 Disease Relevance 0.26 Pain Relevance 0.13
The IMPACT trial included 104 patients with PsA who were seronegative for rheumatoid factor, had at least five tender and five swollen joints, and were refractory to therapy with ?
Positive_regulation (seronegative) of rheumatoid factor in joints associated with arthritis
6) Confidence 0.06 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936360 Disease Relevance 0.93 Pain Relevance 0.81
Infection may cause PPROM and PTL by causing a premature activation of cytokine cascades that in turn, activate the parturition mechanisms described above.
Spec (may) Positive_regulation (cause) of PPROM associated with pre-term labor, infection and cytokine
7) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.28 Pain Relevance 0.28
Psoriatic arthritis (PsA) is a progressive and often destructive form of inflammatory arthritis that frequently occurs in psoriasis patients (Zachariae 2003).
Positive_regulation (Psoriatic) of arthritis associated with seronegative spondarthritis, psoriasis, inflammation and arthritis
8) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936360 Disease Relevance 1.19 Pain Relevance 0.47
PsA has been broadly defined as "an inflammatory arthritis associated with psoriasis which is usually negative for rheumatoid factor" [1].
Positive_regulation (negative) of rheumatoid factor associated with psoriasis, inflammation and arthritis
9) Confidence 0.03 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 2.26 Pain Relevance 1.09
Community surveys have reported incidences of psoriasis in 4.5–5.3% of patients presenting with IA [4,5], but the incidence may be even higher for patients whom are seronegative for rheumatoid factor [6].
Positive_regulation (seronegative) of rheumatoid factor associated with psoriasis and arthritis
10) Confidence 0.03 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 2.89 Pain Relevance 1.28
PChE activity in this population was decreased with increasing levels of arsenic in the drinking water (Figure 2A).
Positive_regulation (increasing) of arsenic
11) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.22 Pain Relevance 0
Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails.
Positive_regulation (increasing) of arsenic in hair
12) Confidence 0.02 Published 2010 Journal Environ Health Section Abstract Doc Link PMC2911418 Disease Relevance 0.29 Pain Relevance 0
Similar effects were also observed with the increasing levels of arsenic in hair and nails (Figure 2B and 2C, respectively).
Positive_regulation (increasing) of arsenic in nails
13) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.23 Pain Relevance 0
A significant decrease in PChE activity was observed with the increasing concentrations of arsenic in drinking water (Figure 2A) with a significant negative correlation (rs = -0.52, p < 0.001).
Positive_regulation (increasing) of arsenic
14) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.11 Pain Relevance 0
Rheumatoid factor was elevated in several dogs.
Positive_regulation (elevated) of Rheumatoid factor
15) Confidence 0.02 Published 1989 Journal Toxicol Pathol Section Abstract Doc Link 2568680 Disease Relevance 1.61 Pain Relevance 0.25
Rheumatoid factor-Latextest and Waaler-Rose-Titers and IgM have been found highly elevated in the serum.
Positive_regulation (elevated) of Rheumatoid factor-Latextest
16) Confidence 0.01 Published 1976 Journal Immun. Infekt. Section Abstract Doc Link 61163 Disease Relevance 0.47 Pain Relevance 0.19
The aim of this paper is to discuss, on the basis of a literature review, the case of a 28-year-old female dental technician who suffered from episodes of weakness, arthralgia, pain, swelling and stiffness of the fingers, dyspnoea with cough, a positive Waaler-Rose reaction, increased rheumatoid factor and normal ESR.
Positive_regulation (increased) of rheumatoid factor in fingers associated with pain, pressure and volume under development, arthralgia, cough and dyspnea
17) Confidence 0.01 Published 2002 Journal Clin. Rheumatol. Section Abstract Doc Link 11954893 Disease Relevance 1.10 Pain Relevance 0.10
Interestingly, during the second twelve weeks there was an increased incidence of arthritis (5.6%); 12 of these 19 cases had had a prior history of arthritis.
Positive_regulation (increased) of arthritis associated with arthritis
18) Confidence 0.01 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.02 Pain Relevance 0.39
Similar effects were also observed with the increasing levels of arsenic in hair and nails (Figure 2B and 2C, respectively).
Positive_regulation (increasing) of arsenic in hair
19) Confidence 0.01 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.23 Pain Relevance 0
Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails.
Positive_regulation (increasing) of arsenic in nails
20) Confidence 0.01 Published 2010 Journal Environ Health Section Abstract Doc Link PMC2911418 Disease Relevance 0.29 Pain Relevance 0

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