INT6210

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 39
Total Number 42
Disease Relevance 14.35
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 7
VSMC 3
renal nerve 2
brain 1
parasympathetic 1
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 12 100.00 Very High Very High Very High
Central nervous system 6 100.00 Very High Very High Very High
Clonidine 43 99.90 Very High Very High Very High
Catecholamine 3 99.04 Very High Very High Very High
lidocaine 7 98.02 Very High Very High Very High
Morphine 7 97.88 Very High Very High Very High
narcan 15 97.44 Very High Very High Very High
opiate 3 96.88 Very High Very High Very High
imagery 19 96.76 Very High Very High Very High
Somatostatin 4 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 119 100.00 Very High Very High Very High
Post-partum Depression 9 100.00 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 19 99.76 Very High Very High Very High
Muscular Spasm 1 99.60 Very High Very High Very High
Papilloma 52 99.52 Very High Very High Very High
Depression 3 99.28 Very High Very High Very High
Incontinence 142 99.16 Very High Very High Very High
Cirrhosis 3 99.10 Very High Very High Very High
Sperm Disorder 3 99.00 Very High Very High Very High
Pressure And Volume Under Development 8 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that ANF can act centrally to alter the hypothalamic control of gonadotropin secretion, possibly by interacting with central dopaminergic and peptidergic systems.
ANF Binding (interacting) of
1) Confidence 0.47 Published 1988 Journal Endocrinology Section Abstract Doc Link 2964365 Disease Relevance 0.07 Pain Relevance 0.22
Specific 125I-ANF binding to retinal particulate preparations was greater than 90% of total binding and saturable at a density (Bmax) of 40 +/- 8 fmol/mg protein with an apparent dissociation constant (Kd) of 6.0 +/- 2.0 pM (n = 3).
ANF Binding (binding) of
2) Confidence 0.45 Published 1989 Journal Life Sci. Section Abstract Doc Link 2544774 Disease Relevance 0.17 Pain Relevance 0
The Kd value of 125I-ANF binding calculated by kinetic analysis was 4.0 pM.
ANF Binding (binding) of
3) Confidence 0.45 Published 1989 Journal Life Sci. Section Abstract Doc Link 2544774 Disease Relevance 0.22 Pain Relevance 0.13
Affinity cross-linking of 125I-ANF to retinal particulate preparations resulted in the labelling of two sites of molecular weight 140 and 66 kDa, respectively.
ANF Binding (cross-linking) of
4) Confidence 0.45 Published 1989 Journal Life Sci. Section Abstract Doc Link 2544774 Disease Relevance 0.16 Pain Relevance 0.20
The 125I-ANF binding to retinal particulate preparations was not inhibited by 1 microM concentration of somatostatin, vasopressin, vasoactive intestinal peptide, adrenocorticotropin, thyrotropin releasing hormone, or leu-enkephalin.
ANF Binding (binding) of associated with somatostatin and enkephalin
5) Confidence 0.45 Published 1989 Journal Life Sci. Section Abstract Doc Link 2544774 Disease Relevance 0.23 Pain Relevance 0.18
Similar to clonidine, ST-91, a clonidine analogue that does not cross the blood-brain barrier, evokes renal responses that are also associated with elevated plasma ANP.
ANP Binding (associated) of in brain associated with clonidine
6) Confidence 0.44 Published 1997 Journal Hypertension Section Abstract Doc Link 9231825 Disease Relevance 0.35 Pain Relevance 0.51
Binding, internalization, and degradation of atrial natriuretic peptide in cultured vascular smooth muscle cells of rat.
atrial natriuretic peptide Binding (Binding) of in smooth muscle cells associated with natriuresis
7) Confidence 0.42 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2866767 Disease Relevance 0.20 Pain Relevance 0.06
Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine.
ANF Binding (Administration) of in renal nerve associated with natriuresis
8) Confidence 0.37 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2969196 Disease Relevance 0.17 Pain Relevance 0.16
Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine.
atrial natriuretic factor Binding (Administration) of in renal nerve associated with natriuresis
9) Confidence 0.37 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2969196 Disease Relevance 0.17 Pain Relevance 0.16
These findings suggest that ANP reduced sodium uptake via inhibition of an amiloride-sensitive pathway for sodium uptake. cGMP is a major intracellular second messenger for ANP in other tissues.
ANP Binding (messenger) of
10) Confidence 0.37 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1324615 Disease Relevance 0.13 Pain Relevance 0.16
At the same time, plasma IR-ANF decreased from 113.3 +/- 32.2 to 30.3 +/- 11.4 after yohimbine and to 24.6 +/- 12.1 pg/ml after naloxone treatment (P less than 0.05).
ANF Binding (decreased) of in plasma associated with narcan
11) Confidence 0.37 Published 1988 Journal Endocrinology Section Abstract Doc Link 2841088 Disease Relevance 0.29 Pain Relevance 0.99
A simple and sensitive radioimmunoassay was developed for measurement of immunoreactive atrial natriuretic factor (IR-ANF) in rat and human plasma and in rat atria.
ANF Binding (measurement) of in plasma associated with natriuresis
12) Confidence 0.37 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2872084 Disease Relevance 0.25 Pain Relevance 0.17
The attenuation of blood pressure could not be associated with the changes in PRA or plasma ANP.
ANP Binding (associated) of in plasma
13) Confidence 0.36 Published 1991 Journal Clin Exp Hypertens A Section Abstract Doc Link 2022070 Disease Relevance 0.57 Pain Relevance 0.44
Because ANP and PGI2 are vasoactive peptides which regulate vasomotion, there must be an interaction between steroidogenesis hormones and vasoactive peptides.
ANP Binding (interaction) of
14) Confidence 0.35 Published 1993 Journal Chin. Med. Sci. J. Section Abstract Doc Link 8032065 Disease Relevance 0.96 Pain Relevance 0.14
We have previously shown that the effects of clonidine are associated with elevated plasma atrial natriuretic peptide (ANP).
ANP Binding (associated) of in plasma associated with natriuresis and clonidine
15) Confidence 0.33 Published 1997 Journal Hypertension Section Abstract Doc Link 9231825 Disease Relevance 0.37 Pain Relevance 0.49
A simple and sensitive radioimmunoassay was developed for measurement of immunoreactive atrial natriuretic factor (IR-ANF) in rat and human plasma and in rat atria.
immunoreactive atrial natriuretic factor Binding (measurement) of in plasma associated with natriuresis
16) Confidence 0.32 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2872084 Disease Relevance 0.25 Pain Relevance 0.17
The high levels of ANP seem to counteract the haemodynamic and fluid-retention effects of the vasoconstrictive factors released after myocardial infarction.
ANP Binding (counteract) of associated with myocardial infarction
17) Confidence 0.32 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1829681 Disease Relevance 0.80 Pain Relevance 0.23
In one patient in this study, PND was associated with DCIS that was not detected by mammography, ultrasound, discharge cytology, MRI or galactography.
PND Binding (associated) of associated with noninfiltrating intraductal carcinoma and imagery
18) Confidence 0.32 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1524964 Disease Relevance 0.70 Pain Relevance 0.05
These data indicate that rANP, after binding to the cell-surface receptors, is rapidly internalized into the cells through receptor-mediated endocytosis, and subsequently degradaded by lysosomal hydrolases.
rANP Binding (binding) of
19) Confidence 0.32 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2866767 Disease Relevance 0.13 Pain Relevance 0.09
For nape contacts, there was a significant exposure × PND interaction [F (1,21) = 5.51, p = 0.03].
PND Binding (interaction) of in nape
20) Confidence 0.31 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257594 Disease Relevance 0.10 Pain Relevance 0

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