INT62112

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 17.18
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
plasma 2
platelet 2
A549 2
neutrophil 2
macrophages 1
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 45 100.00 Very High Very High Very High
nud 20 100.00 Very High Very High Very High
Inflammatory response 15 98.00 Very High Very High Very High
Crohn's disease 1 79.12 Quite High
Inflammation 74 75.00 Quite High
spastic colon 1 74.08 Quite High
Angina 1 50.00 Quite Low
chemokine 4 25.00 Low Low
abdominal pain 10 13.04 Low Low
Pain 2 11.48 Low Low
Disease Link Frequency Relevance Heat
Disease 148 100.00 Very High Very High Very High
Ulcers 70 100.00 Very High Very High Very High
Adhesions 310 99.76 Very High Very High Very High
Sprains And Strains 99 99.60 Very High Very High Very High
Stomach Cancer 24 99.56 Very High Very High Very High
Metaplasia 1 99.18 Very High Very High Very High
INFLAMMATION 91 97.64 Very High Very High Very High
Alagille Syndrome 1 97.00 Very High Very High Very High
Infection 89 96.24 Very High Very High Very High
Gastroesophageal Reflux Disease 7 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chi 2 results did not improve when VacA was entered into the model in the presence of cagA, indicating that only cagA is associated with PUD.
cagA Binding (associated) of associated with peptic ulcer disease
1) Confidence 0.36 Published 1996 Journal J. Infect. Dis. Section Abstract Doc Link 8627069 Disease Relevance 0.94 Pain Relevance 0.47
There was no association between cagA, cagE or vacA genotypes and clinical outcome in the patients.
cagA Neg (no) Binding (association) of
2) Confidence 0.36 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15836708 Disease Relevance 0 Pain Relevance 0
Cytotoxin associated genes A (cagA) and E (cagE), and certain vacuolating cytotoxin (vacA) genotypes are associated with peptic ulcer disease (PUD).
cagA Binding (associated) of associated with peptic ulcer disease and disease
3) Confidence 0.36 Published 2005 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 15836708 Disease Relevance 0.57 Pain Relevance 0.30
HP cagA, cagE and vacA were not associated with PUD.
cagA Binding (associated) of
4) Confidence 0.36 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15836708 Disease Relevance 0 Pain Relevance 0
The phylogenetic analysis did not reveal any association between a particular disease and a specific CagA sequence.


CagA Neg (not) Binding (association) of associated with disease
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.60 Pain Relevance 0
Owing to the inactivation of c-Src via CagA interaction, vinculin is dephosphorylated at tyrosine residues, 100 and 1065, by corresponding phosphatases.
CagA Binding (interaction) of
6) Confidence 0.36 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.97 Pain Relevance 0.09
Present study was performed to identify association of CagA IgG antibody in patients with peptic ulcer.
CagA Binding (association) of associated with ulcers
7) Confidence 0.36 Published 2006 Journal Trop Gastroenterol Section Abstract Doc Link 17310555 Disease Relevance 0.53 Pain Relevance 0.13
The cagA and cagE genes and the vacAs1 genotype were associated with the development of peptic ulcer disease (PUD).
cagA Binding (associated) of associated with peptic ulcer disease and disease
8) Confidence 0.36 Published 2007 Journal Diagn. Microbiol. Infect. Dis. Section Abstract Doc Link 17521839 Disease Relevance 1.17 Pain Relevance 0.38
Some studies have identified an association between the CagA-positive strains and the increased acid secretion that in turn leads to gastro-esophageal reflux.[71] The causative association between H. pylori and GORD needs further research for confirmation.


CagA Binding (association) of associated with gastroesophageal reflux disease and sprains and strains
9) Confidence 0.36 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702974 Disease Relevance 1.37 Pain Relevance 0.05
DNA was extracted and polymerase chain reaction was carried out to determine the cagA and cagE status and vacA alleles.
cagA Spec (determine) Binding (determine) of
10) Confidence 0.36 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15836708 Disease Relevance 0 Pain Relevance 0
In this work, we examined the frequency of the cagA, vacA and iceA genotypes in H. pylori strains isolated from Brazilian patients and correlated these with the clinical manifestations.
cagA Spec (examined) Binding (frequency) of associated with sprains and strains
11) Confidence 0.36 Published 2003 Journal FEMS Immunol. Med. Microbiol. Section Abstract Doc Link 12738389 Disease Relevance 1.48 Pain Relevance 0.25
There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.
CagA Neg (no) Binding (association) of associated with infection
12) Confidence 0.36 Published 2003 Journal Int. J. Med. Microbiol. Section Abstract Doc Link 12635936 Disease Relevance 0.80 Pain Relevance 0.19
MATERIALS AND METHODS: The cagA gene of H. pylori was used to test for mixed infection because it is present in only some strains, and its presence has been associated with ulcers.
cagA Binding (associated) of
13) Confidence 0.36 Published 1996 Journal Helicobacter Section Body Doc Link 9398886 Disease Relevance 0.10 Pain Relevance 0
The possession of the cytotoxin-associated gene (cagA) of Helicobacter pylori is thought to be highly associated with peptic ulcer disease.
cagA Binding (associated) of associated with peptic ulcer disease, ulcers and disease
14) Confidence 0.36 Published 1998 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 9570243 Disease Relevance 0.64 Pain Relevance 0.10
RESULTS: The cagA genotype and phenotype were found to be differently associated with disease status.
cagA Binding (associated) of
15) Confidence 0.36 Published 2000 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11111777 Disease Relevance 0.21 Pain Relevance 0
Their combination with vacA allele subtypes and with the cagA status allowed to differentiate 140 isolates in 51 subtypes.
cagA Binding (combination) of
16) Confidence 0.36 Published 2000 Journal Med. Microbiol. Immunol. Section Abstract Doc Link 11138636 Disease Relevance 0.20 Pain Relevance 0.07
Different results reporting that cagA gene is not associated with more serious diseases, lowers the importance of CagA protein as a marker.
cagA Binding (associated) of associated with disease
17) Confidence 0.36 Published 2001 Journal Helicobacter Section Abstract Doc Link 11422473 Disease Relevance 0.63 Pain Relevance 0.22
Helicobacter pylori strains positive for both VacA and CagA were reported to be strongly associated with peptic ulcer disease.
CagA Binding (associated) of associated with peptic ulcer disease, disease and sprains and strains
18) Confidence 0.36 Published 2001 Journal Helicobacter Section Abstract Doc Link 11422473 Disease Relevance 0.64 Pain Relevance 0.22
CagA status in dyspeptic patients with and without peptic ulcer disease in Turkey: association with histopathologic findings.
CagA Binding (association) of associated with peptic ulcer disease, nud and disease
19) Confidence 0.36 Published 2001 Journal Helicobacter Section Title Doc Link 11422473 Disease Relevance 0.66 Pain Relevance 0.33
Here, we determine the cagA, vacA and allele status of H. pylori strains isolated from patients with upper gastrointestinal symptoms in Changsha, China.
cagA Binding (determine) of in upper associated with sprains and strains
20) Confidence 0.36 Published 2002 Journal Br. J. Biomed. Sci. Section Abstract Doc Link 12371056 Disease Relevance 0.75 Pain Relevance 0.09

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