INT62124

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 27
Speculated 13
Reported most in Body
Documents 444
Total Number 457
Disease Relevance 218.08
Pain Relevance 114.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 32
brain 17
spinal cord 16
nerve 12
neurons 10
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3186 100.00 Very High Very High Very High
cytokine 1215 100.00 Very High Very High Very High
gABA 327 100.00 Very High Very High Very High
substance P 251 100.00 Very High Very High Very High
Dopamine 163 100.00 Very High Very High Very High
Calcitonin gene-related peptide 148 100.00 Very High Very High Very High
depression 121 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 111 100.00 Very High Very High Very High
Inflammatory mediators 110 100.00 Very High Very High Very High
Neuropeptide 59 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3689 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 1373 100.00 Very High Very High Very High
Targeted Disruption 656 100.00 Very High Very High Very High
Syndrome 168 100.00 Very High Very High Very High
Depression 125 100.00 Very High Very High Very High
Adenocarcinoma 63 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 5 100.00 Very High Very High Very High
Ganglion Cysts 400 99.98 Very High Very High Very High
Stress 2892 99.92 Very High Very High Very High
Muscle Disease 24 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although microvascular tone would be expected to have a relatively limited impact on blood pressure, the fact that nNOS is also expressed in the central nervous system and the kidneys raises the possibility that its combined actions in these three systems may have significant effects on blood pressure regulation.
Gene_expression (expressed) of nNOS in blood associated with central nervous system
1) Confidence 0.78 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.34 Pain Relevance 0.15
Similar profiles of nerve structures expressing immunoreactivities for NOS and tyrosine-hydroxylase (TH), as well as NOS and vasoactive intestinal peptide (VIP) were demonstrated.
Gene_expression (expressing) of NOS in nerve
2) Confidence 0.74 Published 1997 Journal Neurourol. Urodyn. Section Abstract Doc Link 9136143 Disease Relevance 0 Pain Relevance 0.10
The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.
Gene_expression (expression) of nNOS in enteric nervous system associated with diabetes mellitus and substance p
3) Confidence 0.73 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.70 Pain Relevance 0.11
RESULTS: A different pattern of nitric oxide synthase expression was confirmed by nicotinamide adenine dinucleotide phosphate-diaphorase staining and immunohistochemical testing for endothelial and neuronal nitric oxide synthase.
Gene_expression (expression) of nitric oxide synthase in neuronal
4) Confidence 0.69 Published 2001 Journal J. Urol. Section Body Doc Link 11342964 Disease Relevance 0.08 Pain Relevance 0
In addition to endothelial nitric oxide synthase expression, detrusor smooth muscle was recognized as an important location of endothelial nitric oxide synthase, while the urothelium had only small endothelial nitric oxide synthase positive cell clusters.
Gene_expression (expression) of nitric oxide synthase in smooth muscle
5) Confidence 0.69 Published 2001 Journal J. Urol. Section Body Doc Link 11342964 Disease Relevance 0.07 Pain Relevance 0
Neuronal nitric oxide synthase expression was only found in nitrinergic fibers of the submucosal surface and between muscle cells.
Gene_expression (expression) of nitric oxide synthase in muscle cells
6) Confidence 0.69 Published 2001 Journal J. Urol. Section Body Doc Link 11342964 Disease Relevance 0.06 Pain Relevance 0
It was also found that estrogen treatment down-regulates eNOS and nNOS expression in the rabbit vagina [41].
Gene_expression (expression) of nNOS in vagina
7) Confidence 0.69 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0 Pain Relevance 0.15
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Gene_expression (overexpression) of nNOS in phagocyte
8) Confidence 0.69 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.87 Pain Relevance 0.20
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Gene_expression (overexpression) of neuronal nitric-oxide synthase in phagocyte
9) Confidence 0.69 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.87 Pain Relevance 0.20
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Gene_expression (overexpression) of nNOS
10) Confidence 0.69 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.15
Western blotting showed that enterocytes expressed the inducible NOS protein and proteins with nitrated tyrosine residues, the latter being indicative of nitric oxide-driven peroxynitrite and/or free-radical damage.
Gene_expression (expressed) of NOS in enterocytes
11) Confidence 0.68 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12121878 Disease Relevance 0.56 Pain Relevance 0.09
The availability of selective nNOS inhibitors, as well as studies in gene-modified mice with perturbation of nNOS expression, have provided evidence that nonneuronal nNOS is physiologically active and exerts important regulatory influences in a number of different tissues.
Gene_expression (expression) of nNOS
12) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.07 Pain Relevance 0.25
Although l-NMMA inhibits the activity of all NOS isoforms, the observation that eNOS is the major NOS isoform expressed in endothelial cells combined with ex vivo studies in human vessels confirming the central role of the endothelium in vascular responses support the conclusion that eNOS is the predominant source of NO responsible for the regulation of vascular tone (Moncada et al. 1993, 2006).
Gene_expression (expressed) of NOS in endothelium
13) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.41 Pain Relevance 0.19
In contrast, the same stimulus led to reduced vasoconstriction in healthy children or in patients with different muscle disorders where nNOS expression was expected to be intact (Sander et al. 2000).
Gene_expression (expression) of nNOS in muscle associated with muscle disease and increased venous pressure under development
14) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.51 Pain Relevance 0.03
The absence of dystrophin, as seen in patients with Duchenne muscular dystrophy (DMD) and its animal equivalent the mdx mouse, leads to a significant reduction in skeletal muscle nNOS expression and in skeletal muscle blood flow (Brenman et al. 1995).
Gene_expression (expression) of nNOS in blood associated with muscular dystrophy
15) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.35 Pain Relevance 0.28
In addition to the central nervous system, nNOS is now known to also be expressed in many nonneuronal cell types such as skeletal (Kobzik et al. 1994) and cardiac myocytes (Xu et al. 1999), cells of the macula densa within the kidney (Bachmann et al. 1995), and selected smooth muscle (Boulanger et al. 1998) and endothelial (Bachetti et al. 2004) cells.
Gene_expression (expressed) of nNOS in central nervous system associated with central nervous system
16) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.15 Pain Relevance 0.31
The nNOS isoform is expressed in most regions of the central nervous system, in parasympathetic ganglia and in selected nonadrenergic noncholinergic peripheral autonomic nerve fibers (or “nitrergic” nerves) (Schuman and Madison 1994, Toda and Okamura 2003).
Gene_expression (expressed) of nNOS isoform in central nervous system associated with central nervous system
17) Confidence 0.68 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.23 Pain Relevance 0.22
Large and small calibre nitrergic nerves were demonstrated with immunohistochemistry using nNOS antibody, which were also immunostained with cholinergic nerve markers. nNOS expression was confirmed using Western blotting.
Gene_expression (expression) of nNOS in nerve
18) Confidence 0.68 Published 2004 Journal Int. J. Impot. Res. Section Abstract Doc Link 14961056 Disease Relevance 0 Pain Relevance 0.13
Fluoxetine inhibits dendrite atrophy of hippocampal neurons by decreasing nitric oxide synthase expression in rat depression model.
Gene_expression (expression) of nitric oxide synthase in dendrite associated with depression, frailty and fluoxetine
19) Confidence 0.67 Published 2001 Journal Acta Pharmacol. Sin. Section Title Doc Link 11749766 Disease Relevance 0.20 Pain Relevance 0.29
CONCLUSION: Fluoxetine, an antidepressant, renormalizes dendrite atrophy of hippocampal neurons by inhibiting nitric oxide synthase overexpression in rat chronic mild stress model.


Gene_expression (overexpression) of nitric oxide synthase in neurons
20) Confidence 0.67 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749766 Disease Relevance 0.14 Pain Relevance 0

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