INT62127

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 10.21
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
suprachiasmatic nucleus 3
hypothalamus 1
plasma 1
ganglion cells 1
pineal gland 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 17 100.00 Very High Very High Very High
gABA 18 99.98 Very High Very High Very High
Glutamate 3 99.96 Very High Very High Very High
Neuropeptide 9 99.24 Very High Very High Very High
depression 25 99.00 Very High Very High Very High
Neurotransmitter 6 95.88 Very High Very High Very High
GABA receptor 1 88.28 High High
GABAergic 10 86.20 High High
midbrain 3 80.24 Quite High
Raphe 8 79.52 Quite High
Disease Link Frequency Relevance Heat
Respiratory Failure 198 100.00 Very High Very High Very High
Neutrophil Disorders 22 100.00 Very High Very High Very High
Ganglion Cysts 5 99.56 Very High Very High Very High
Anxiety Disorder 71 99.52 Very High Very High Very High
Depression 37 99.00 Very High Very High Very High
Disease 295 98.16 Very High Very High Very High
Arrhythmia Under Development 51 95.40 Very High Very High Very High
Neutropenia 3 94.56 High High
Weight Gain 15 93.40 High High
Appetite Loss 3 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRI-SR :SRI subdomain social relationship;
Localization (relationship) of SRI associated with respiratory failure
1) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.09 Pain Relevance 0
SRI-SR :SRI subdomain social relationship;
Localization (relationship) of SRI-SR associated with respiratory failure
2) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.10 Pain Relevance 0
In theory, SCN and CN are caused by an accumulation of neutrophil elastase, leading to an inactivation of G-CSF and a negative feedback on granulopoiesis, which causes neutropenia.
Localization (caused) of SCN in neutrophil associated with neutropenia and neutrophil disorders
3) Confidence 0.30 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.91 Pain Relevance 0
As mentioned above, alterations in the SCN and melatonin secretion are assumed to be the main reason for CRD in AD [10].
Localization (secretion) of SCN associated with disease
4) Confidence 0.30 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.46 Pain Relevance 0.11
These inputs are conveyed through the retinohypothalamic tract (RHT) resulting in oscillation of SCN and melatonin secretion [13–15].
Localization (secretion) of SCN
5) Confidence 0.27 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.21 Pain Relevance 0.11
The main reason for the alteration in sleep-wake cycle is related to alterations in the suprachiasmatic nucleus (SCN) and melatonin secretion [10].
Localization (secretion) of SCN in suprachiasmatic nucleus
6) Confidence 0.27 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 1.19 Pain Relevance 0
The SCN is located in the anterior hypothalamus and regulates the circadian rhythms of several physiological systems, including sleep, and the secretion of hormones involved in energy balance regulation [55].
Localization (located) of SCN in hypothalamus
7) Confidence 0.24 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.48 Pain Relevance 0
The phase-resetting effects are relatively well understood and a participation of the SCN in sleep initiation cannot be denied.
Localization (participation) of SCN
8) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.06 Pain Relevance 0.08
Furthermore, various sources indicate that receptors for melatonin, progesterone, and estrogen can all be found at the SCN [81, 82], POAH [82, 83], and pineal gland [84, 85].
Localization (found) of SCN in pineal gland
9) Confidence 0.10 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
Classically, peripheral clocks are thought to be controlled by a central clock located in the suprachiasmatic nucleus (SCN), which is believed to also synchronize clocks in other brain regions [21].
Localization (located) of SCN in suprachiasmatic nucleus
10) Confidence 0.07 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.07
For the Per1 and Per2 time course experiment, 6 consecutive SCN sections from each mouse were used but multiple mice were not pooled for analysis.
Localization (sections) of SCN
11) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.06 Pain Relevance 0.03
The mean apparent volume of distribution for fluvoxamine is approximately 25 L/kg, suggesting extensive tissue distribution.28 The plasma protein binding of fluvoxamine has been reported to be circa 80%,27,30 the lowest value for any of the selectve SRI.26
Localization (selectve) of SRI in plasma associated with ssri
12) Confidence 0.04 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699655 Disease Relevance 0.09 Pain Relevance 0.21
These ganglion cells project to the SCN and release glutamate and the neuropeptide pituitary adenylyl cyclase activating peptide (PACAP) as the principal neurotransmitters for light entrainment [21].
Localization (release) of SCN in ganglion cells associated with ganglion cysts, neurotransmitter, glutamate and neuropeptide
13) Confidence 0.04 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0.20 Pain Relevance 0.33
NPY showed a dose-dependent rapid depression of the amplitude of Ca2+ rises generated by GABA released from presynaptic SCN axons.
Localization (released) of SCN in SCN associated with gaba and depression
14) Confidence 0.02 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8627385 Disease Relevance 0.36 Pain Relevance 0.59

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