INT62141

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.47
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
nucleus pulposus 4
brain 2
MSC 2
temporal cortex 2
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 81 99.84 Very High Very High Very High
fluoxetine 30 98.80 Very High Very High Very High
antagonist 17 98.24 Very High Very High Very High
Potency 5 97.78 Very High Very High Very High
sSRI 49 96.92 Very High Very High Very High
antidepressant 36 94.68 High High
agonist 7 93.00 High High
depression 45 88.32 High High
Dopamine 21 84.24 Quite High
Dismenorea 5 80.32 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 211 99.76 Very High Very High Very High
Cognitive Disorder 4 98.12 Very High Very High Very High
Schizophrenia 37 96.72 Very High Very High Very High
Major Depressive Disorder 27 93.00 High High
Depression 52 88.32 High High
Aggression 1 86.64 High High
Reprotox - General 1 6 80.32 Quite High
Hypercalcemia 1 77.96 Quite High
Reprotox - General 2 6 73.76 Quite High
Weight Gain 5 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation.
Positive_regulation (increase) of Gene_expression (expression) of 5HT2A in brain associated with cognitive disorder
1) Confidence 0.67 Published 2004 Journal Neuropsychopharmacol Hung Section Abstract Doc Link 15816306 Disease Relevance 0.67 Pain Relevance 0.40
The expression of 5-HT2A receptors was enhanced in a time-dependent manner by nucleus pulposus.
Positive_regulation (enhanced) of Gene_expression (expression) of 5-HT2A in nucleus pulposus
2) Confidence 0.67 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0 Pain Relevance 0
MDL 100,907 had subnanomolar potency as a 5-HT2A antagonist in vitro in reversing 5-HT-stimulated inositol phosphate accumulation in NIH 3T3 cells transfected with the rat 5-HT2A receptor.
Positive_regulation (transfected) of Gene_expression (transfected) of 5-HT2A associated with antagonist and potency
3) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627580 Disease Relevance 0 Pain Relevance 0.18
CONCLUSION: Exogenous 5-HT to the nerve root induced pain-related behavior with short-lasting effects compared with the nucleus pulposus application. 5-HIAA content in plasma and expression of 5-HT2A receptors in DRG neurons increased early time points after the nucleus pulposus application.
Positive_regulation (increased) of Gene_expression (expression) of 5-HT2A in nucleus pulposus
4) Confidence 0.49 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0 Pain Relevance 0
The activation of postsynaptic 5-HT2A and 5-HT2C receptors may be important in the improvement of OCD symptoms after treatment with an SSRI.45 Studies in OCD patients showed blunted prolactin and cortisol responses to 5-HT2 receptor agonists.46 Enoch et al.47 recruited and genotyped 101 Caucasian OCD patients (48 females, 53 males) and 138 control subjects (77 females, 61 males) and found that the -1438A allele frequency was higher only in female OCD patients and not in male patients.
Positive_regulation (activation) of Gene_expression (receptors) of 5-HT2A associated with anxiety disorder, agonist and ssri
5) Confidence 0.49 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.88 Pain Relevance 0.19
Moderate affinity was also found for D4, 5-HT2C, 5-HT7, ?
Positive_regulation (for) of Gene_expression (found) of 5-HT2
6) Confidence 0.49 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.48 Pain Relevance 0.14
Proliferation of human mesenchymal stem cells (MSC) and primary osteoblasts (NHO), and 5-HT2A receptor expression was enhanced by serotonin.
Positive_regulation (enhanced) of Gene_expression (expression) of 5-HT2 in MSC associated with serotonin
7) Confidence 0.45 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.13 Pain Relevance 1.08
The 5-HT2A T102C C-allele specific methylation has been associated with increased 5-HT2A receptor expression in human temporal cortex [13], and allele-specific methylation has been proposed as a modulator in gene-environment interactions [14].
Positive_regulation (increased) of Gene_expression (expression) of 5-HT2A in temporal cortex
8) Confidence 0.30 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.31 Pain Relevance 0.44

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