INT62155

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 6.17
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
muscle 6
neck 4
heart 4
B cells 3
skeletal muscle 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 24 97.08 Very High Very High Very High
Pain 12 89.16 High High
withdrawal 4 85.48 High High
cytokine 36 75.00 Quite High
headache 62 70.96 Quite High
corticosteroid 9 31.88 Quite Low
fibrosis 116 18.72 Low Low
cINOD 3 5.68 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
imagery 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 99.84 Very High Very High Very High
Muscular Dystrophy 722 99.64 Very High Very High Very High
Osteoporosis 265 99.50 Very High Very High Very High
Chronic Hepatitis 23 99.28 Very High Very High Very High
Cardiomyopathy 190 95.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 73 95.64 Very High Very High Very High
Hypercalcemia 58 95.44 Very High Very High Very High
Myalgia 3 92.64 High High
Cramps 4 91.68 High High
Breast Cancer 48 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The determined nucleotide sequence of the amplified product encompassing exons 10 to 20 disclosed that the entire segment corresponding to exons 13 to 18 (810 bp) was absent, a deletion that would be expected to cause the production of a dystrophin protein lacking 270 amino acids from the rod domain.
Positive_regulation (cause) of Gene_expression (production) of dystrophin
1) Confidence 0.67 Published 1996 Journal Neurology Section Abstract Doc Link 8628480 Disease Relevance 0.82 Pain Relevance 0
Western blot analysis detected increased expression of dystrophin in the AVI-4658-treated muscle of all patients who received the high dose, and the immunoblot detected expression of dystrophin of the expected molecular weight in all patients.
Positive_regulation (increased) of Gene_expression (expression) of dystrophin in muscle
2) Confidence 0.67 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.12 Pain Relevance 0
Our controlled study of exon skipping for DMD clearly shows an increase in the expression of dystrophin in drug-treated muscles compared with the saline-injected contralateral muscle.
Positive_regulation (increase) of Gene_expression (expression) of dystrophin in muscle associated with muscular dystrophy
3) Confidence 0.67 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.37 Pain Relevance 0
In a recent study the use of an arginine-rich cell-penetrating peptide, conjugated PMO has been shown to successfully restore the dystrophin expression in the heart and to significantly improve the sarcolemma integrity and prevent the development of the cardiomyopathy [85].
Positive_regulation (restore) of Gene_expression (expression) of dystrophin in heart associated with cardiomyopathy
4) Confidence 0.45 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.24 Pain Relevance 0
The restoration of the open reading frame in the mutated dystrophin gene using antisense oligonucleotides, which allow exon skipping over the mutated exons and create shortened transcripts that are able to generate a truncated but functional dystrophin have shown in small scale trials to be effective for improving the dystrophin expression in skeletal muscle [83].
Positive_regulation (effective) of Gene_expression (expression) of dystrophin in skeletal muscle
5) Confidence 0.45 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.06 Pain Relevance 0
It is also able to restore the dystrophin expression in the hearts of mdx mice after 4 weeks of treatment [87].
Positive_regulation (restore) of Gene_expression (expression) of dystrophin in hearts
6) Confidence 0.45 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.54 Pain Relevance 0
Intramuscular injection of the higher-dose of AVI-4658 resulted in increased dystrophin expression in all treated EDB muscles, although the results of the immunostaining of EDB-treated muscle for dystrophin were not uniform.
Positive_regulation (increased) of Gene_expression (expression) of dystrophin in muscle
7) Confidence 0.45 Published 2009 Journal Lancet Neurol Section Abstract Doc Link PMC2755039 Disease Relevance 0.27 Pain Relevance 0
In the areas of the immunostained sections that were adjacent to the needle track through which AVI-4658 was given, 44–79% of myofibres had increased expression of dystrophin.
Positive_regulation (increased) of Gene_expression (expression) of dystrophin
8) Confidence 0.45 Published 2009 Journal Lancet Neurol Section Abstract Doc Link PMC2755039 Disease Relevance 0.19 Pain Relevance 0
Systemic injection of the ZM2-AON complex restored dystrophin protein synthesis in both skeletal and cardiac muscles of mdx mice, allowing protein localization in up to 40% of muscle fibers.
Positive_regulation (restored) of Gene_expression (synthesis) of dystrophin in muscle fibers
9) Confidence 0.45 Published 2010 Journal Gene Ther. Section Abstract Doc Link 19907501 Disease Relevance 0.16 Pain Relevance 0.09
Any immune response against the newly synthesised dystrophin was assessed by the production of anti-dystrophin antibodies: serum samples were used to probe western blots loaded with lysates of muscle from the AD17 transgenic mouse, which overexpresses full-length human dystrophin; goat anti-human-IgG was used as the secondary antibody (Bio-Rad, UK).40 The presence of T cells and B cells in each biopsy was ascertained by immunohistochemistry with antibodies raised against human CD3, CD4, CD8, or CD20 (Dako, UK).
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of dystrophin in B cells associated with targeted disruption
10) Confidence 0.45 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.25 Pain Relevance 0.09
This study showed that sequential treatment of osteoporotic patients with PTH followed by alendronate results in a further increase in vertebral BMD that is significantly higher than BMD gained with PTH only and also with simultaneous alendronate and PTH.
Positive_regulation (higher) of Gene_expression (gained) of BMD
11) Confidence 0.17 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.06 Pain Relevance 0.07
Any immune response against the newly synthesised dystrophin was assessed by the production of anti-dystrophin antibodies: serum samples were used to probe western blots loaded with lysates of muscle from the AD17 transgenic mouse, which overexpresses full-length human dystrophin; goat anti-human-IgG was used as the secondary antibody (Bio-Rad, UK).40 The presence of T cells and B cells in each biopsy was ascertained by immunohistochemistry with antibodies raised against human CD3, CD4, CD8, or CD20 (Dako, UK).
Positive_regulation (overexpresses) of in T cells Gene_expression (overexpresses) of dystrophin in B cells associated with targeted disruption
12) Confidence 0.15 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.25 Pain Relevance 0.09
These results suggest that parathyroid hormone treatment in conjunction with estrogen therapy results in a significant BMD increase in the lumbar spine and hip in postmenopausal women with GIOP when compared with treatment with estrogen alone.34 However, what is more interesting is that bone mass continued to increase after parathyroid hormone treatment (of 12 months’ duration) was discontinued, and this is particularly true for BMD values at the total hip and femoral neck.34
Positive_regulation (true) of Gene_expression (values) of BMD in hip associated with osteoporosis
13) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.19 Pain Relevance 0
Osteoporosis in its most common form occurs in both the sexes of elderly and all racial groups affecting the BMD.
Positive_regulation (occurs) of Gene_expression (affecting) of BMD associated with osteoporosis
14) Confidence 0.06 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 0.83 Pain Relevance 0
Exemestane induced a non significant increase in the mean annual rate of BMD loss at lumbar spine with respect to placebo (2.17% vs 1.84%) and a slightly significant increase in femoral neck BMD (2.72% vs 1.48%; p = 0.02) (Lonning et al 2005).
Positive_regulation (induced) of Gene_expression (loss) of BMD in neck
15) Confidence 0.05 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.34 Pain Relevance 0
While other dosing frequencies may increase BMD (e.g. continuous dosing, or even once weekly dosing), data from both the cardiovascular literature and our observational study suggest that too frequent dosing (e.g.
Spec (may) Positive_regulation (increase) of Gene_expression (dosing) of BMD
16) Confidence 0.04 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.18 Pain Relevance 0.23
Although we showed that donor human SC can engraft, differentiate, and persist in the host, it seems that the apparent clinical benefit observed in treated animals is not due to dystrophin expression in the host muscles, but due to their immune modulatory effect of SC from dental pulp [14,15,17,32].
Neg (not) Positive_regulation (due) of Gene_expression (expression) of dystrophin in dental pulp
17) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2529267 Disease Relevance 0.32 Pain Relevance 0
mg/d micronized progesterone resulted in similar increases in femur neck BMD (0.73% and 0.92%, respectively) after 18 months of treatment while the control group experienced a significant decrease in BMD (?
Positive_regulation (increases) of Gene_expression (neck) of BMD in neck
18) Confidence 0.03 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957171 Disease Relevance 0.06 Pain Relevance 0.20
It also improves BMD in postmenopausal women [90].
Positive_regulation (improves) of Gene_expression (improves) of BMD
19) Confidence 0.02 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2974929 Disease Relevance 0.45 Pain Relevance 0
In conclusion, our study suggest that BMD of femur, serum IL-2r, IL-6, IL-8, PTH, and CTX levels were higher in children with chronic hepatitis B treated with IFN-alpha alone or combination with lamivudine than in healthy children.
Positive_regulation (higher) of Gene_expression (levels) of BMD in femur associated with chronic hepatitis
20) Confidence 0.01 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1242225 Disease Relevance 0.47 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox