INT62166

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 64
Total Number 66
Disease Relevance 39.13
Pain Relevance 9.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 12
plasma 10
bile 4
hepatocyte 2
poly 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 450 100.00 Very High Very High Very High
ischemia 45 100.00 Very High Very High Very High
Inflammation 239 99.32 Very High Very High Very High
Pain 72 98.24 Very High Very High Very High
diclofenac 40 97.12 Very High Very High Very High
Bile 87 96.36 Very High Very High Very High
alcohol 28 94.60 High High
fibrosis 71 94.20 High High
cINOD 35 93.16 High High
aspirin 11 92.72 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 63 100.00 Very High Very High Very High
Targeted Disruption 48 100.00 Very High Very High Very High
Hepatitis B Virus Infection 82 99.82 Very High Very High Very High
Hepatitis C Virus Infection 166 99.76 Very High Very High Very High
Hypotension 12 99.76 Very High Very High Very High
Hepatocellular Cancer 290 99.72 Very High Very High Very High
Injury 260 99.64 Very High Very High Very High
Hepatotoxicity 96 99.60 Very High Very High Very High
Urological Neuroanatomy 28 99.40 Very High Very High Very High
INFLAMMATION 287 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
General observations of gpt delta transgenic mice administrated with particles
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of gpt associated with targeted disruption
1) Confidence 0.50 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.26 Pain Relevance 0
General observations of gpt delta transgenic mice administrated with particles
Positive_regulation (observations) of Gene_expression (transgenic mice) of gpt associated with targeted disruption
2) Confidence 0.50 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.26 Pain Relevance 0
A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP.
Positive_regulation (elevation) of Gene_expression (levels) of ALT associated with paracetamol
3) Confidence 0.49 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.69 Pain Relevance 0.70
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Positive_regulation (increases) of Gene_expression (levels) of ALT in plasma associated with paracetamol
4) Confidence 0.47 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.38
In contrast, after sunitinib was administered at escalating doses, the serum AST and ALT levels were only slightly elevated and mild liver damage with slight vascular congestion and signs of hepatocyte regeneration were found (Figure 3).
Positive_regulation (elevated) of Gene_expression (levels) of ALT in hepatocyte associated with hepatotoxicity
5) Confidence 0.45 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.55 Pain Relevance 0.50
However, at higher doses of sunitinib in group D, both the AST and ALT levels were significantly increased (Figure 1).
Positive_regulation (increased) of Gene_expression (levels) of ALT
6) Confidence 0.45 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.42 Pain Relevance 0.48
Spi- MFs in the lungs of gpt transgenic mice with particle treatment
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of gpt in lungs associated with targeted disruption
7) Confidence 0.43 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.15 Pain Relevance 0
A detailed time course indicated that aminoguanidine (15 mg/kg at 0 h and 15 mg/kg at 2 h) significantly increased serum ALT levels over that for acetaminophen alone at 2 and 4 h; however, at 6 and 8 h serum ALT levels in the two groups were identical.
Positive_regulation (increased) of Gene_expression (levels) of ALT associated with paracetamol
8) Confidence 0.42 Published 2002 Journal Nitric Oxide Section Abstract Doc Link 11890740 Disease Relevance 0.34 Pain Relevance 0.80
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Positive_regulation (increased) of Gene_expression (levels) of ALT
9) Confidence 0.41 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.18 Pain Relevance 0.65
As expected, a large increase in serum ALT levels was observed after administration of paracetamol only (249.60 ± 222.72 U/L) although it did not reach statistical difference with the baseline control value, probably due to the large variability.
Positive_regulation (increase) of Gene_expression (levels) of serum ALT associated with paracetamol
10) Confidence 0.39 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0 Pain Relevance 0.52
Since the increases in ALT produced were highly variable (even after log transformation) and complicated the statistical analyses, we calculated confidence intervals for the mean ALT levels for each treatment group.
Spec (analyses) Positive_regulation (increases) of Gene_expression (produced) of ALT
11) Confidence 0.37 Published 1996 Journal J. Biochem. Toxicol. Section Abstract Doc Link 9176740 Disease Relevance 0.16 Pain Relevance 0.34
Set IV A results (Table 10) clearly depict an increase in serum AST and ALT levels indicating hepatotoxicity to a mild extent.
Positive_regulation (increase) of Gene_expression (levels) of ALT associated with hepatotoxicity
12) Confidence 0.35 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2661047 Disease Relevance 0.44 Pain Relevance 0
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Positive_regulation (increases) of Gene_expression (depletion) of ALT associated with paracetamol and hepatotoxicity
13) Confidence 0.34 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
This data is consistent with plasma ALT data, which showed a maximal increase in ALT levels at I/R 6 h, followed by a decrease in levels by I/R 15 h of reperfusion.
Positive_regulation (increase) of Gene_expression (levels) of ALT in plasma
14) Confidence 0.32 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.25 Pain Relevance 0.24
The plasma ALT levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated when compared to their respective sham-operated mice (Figure 2).
Positive_regulation (elevated) of Gene_expression (levels) of ALT in plasma associated with ischemia
15) Confidence 0.32 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.38 Pain Relevance 0.05
Serum levels of ALT and AST were significantly increased in 14- and 22-week-old mice fed a basal diet and in 22-week-old mice fed a high-fat diet compared with those in 6-week-old mice.
Positive_regulation (increased) of Gene_expression (levels) of ALT in fat
16) Confidence 0.25 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.53 Pain Relevance 0.04
Concurrently, the mean levels of AST and ALT were significantly elevated in the Pb+LPS group to 720 U/L and 600 U/L, respectively.
Positive_regulation (elevated) of Gene_expression (levels) of ALT
17) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.27 Pain Relevance 0
 ; (IL-6): interleukin-6; (ROS): reactive oxygen species; (PARP): poly (ADP-ribose) polymerase; (NO2/NO3): Nitrite/nitrate; (MPO): Myeloperoxidase activity; (ALT): alanine aminotransferase; (AST): aspartate aminotransferase; (iNOS): inducible nitric oxide.


Positive_regulation (inducible) of Gene_expression (oxide) of ALT in poly associated with urological neuroanatomy
18) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.93 Pain Relevance 0.08
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Positive_regulation (cloned) of Gene_expression (cloned) of ALT in liver associated with hepatotoxicity
19) Confidence 0.22 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.84 Pain Relevance 0
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Positive_regulation (rat) of Gene_expression (isoenzyme) of ALT in liver associated with hepatotoxicity
20) Confidence 0.22 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.84 Pain Relevance 0

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