INT62169

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1996
Last Reported 2011
Negated 0
Speculated 4
Reported most in Abstract
Documents 72
Total Number 77
Disease Relevance 14.56
Pain Relevance 27.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 21
pigmentation 6
skin 4
macrophages 1
tail 1
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 975 100.00 Very High Very High Very High
agonist 44 99.28 Very High Very High Very High
Inflammation 99 98.88 Very High Very High Very High
antagonist 16 98.68 Very High Very High Very High
cytokine 32 98.32 Very High Very High Very High
opiate 6 97.96 Very High Very High Very High
Kinase C 3 97.22 Very High Very High Very High
addiction 7 95.28 Very High Very High Very High
adenocard 6 93.04 High High
Potency 7 91.24 High High
Disease Link Frequency Relevance Heat
Skin Cancer 117 100.00 Very High Very High Very High
Melanoma 624 99.78 Very High Very High Very High
Freckles 59 99.44 Very High Very High Very High
Stress 8 99.36 Very High Very High Very High
INFLAMMATION 115 98.88 Very High Very High Very High
Cancer 86 98.84 Very High Very High Very High
Hypopigmentation 8 98.84 Very High Very High Very High
Shock 1 98.38 Very High Very High Very High
Lung Cancer 9 96.68 Very High Very High Very High
Death 16 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of protein kinase C by 12-0-tetradecanoylphorbol-13-acetate slightly increased, while stimulation of adenylate cyclase by forskolin markedly up-regulated the MC1R mRNA level. beta-Estradiol increased, and combined treatment with beta-estradiol and alpha-MSH further elevated, MC1R mRNA level in NHM-c and NHM-b.
Positive_regulation (increased) of MC1R mRNA in NHM associated with kinase c and melanocortin 1 receptor
1) Confidence 0.69 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.95
Treatment of NHM with alpha-melanotropin [alpha-melanocyte stimulating hormone (alpha-MSH)] increased MC1R mRNA level; the response was often more pronounced in NHM with a low (NHM-c) than in NHM with a high melanin content (NHM-b).
Positive_regulation (increased) of MC1R mRNA in NHM associated with melanocortin 1 receptor
2) Confidence 0.69 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.68
The melanotropic actions of alpha-melanocyte-stimulating hormone (alpha-MSH) and other melanocortins are mediated by activation of the melanocortin 1 receptor (MC1R).
Positive_regulation (activation) of melanocortin 1 receptor in melanocyte associated with melanocortin 1 receptor
3) Confidence 0.69 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12950734 Disease Relevance 0.08 Pain Relevance 0.47
The melanotropic actions of alpha-melanocyte-stimulating hormone (alpha-MSH) and other melanocortins are mediated by activation of the melanocortin 1 receptor (MC1R).
Positive_regulation (activation) of MC1R in melanocyte associated with melanocortin 1 receptor
4) Confidence 0.69 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12950734 Disease Relevance 0.08 Pain Relevance 0.47
We also showed that the activation of the MC1R is important for the melanogenic response of human melanocytes to ultraviolet radiation (UVR).
Positive_regulation (activation) of MC1R in melanocytes associated with melanocortin 1 receptor
5) Confidence 0.69 Published 2000 Journal Pigment Cell Res. Section Abstract Doc Link 11041375 Disease Relevance 0 Pain Relevance 0.78
MC1-R mRNA in subcutaneous fat was increased in obese patients as compared with controls; omental fat of both groups had slightly higher MC1-R expression than subcutaneous fat and did not differ between patient groups.
Positive_regulation (increased) of MC1-R in fat
6) Confidence 0.69 Published 2007 Journal Obesity (Silver Spring) Section Body Doc Link 17228030 Disease Relevance 0.15 Pain Relevance 0
alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.
Positive_regulation (activate) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
7) Confidence 0.69 Published 2009 Journal Pigment cell & melanoma research Section Title Doc Link 19558415 Disease Relevance 0.10 Pain Relevance 0.10
We therefore suggest that the most likely explanation for our results is that MC1R activity is increased in both C. atratus and Coscoroba, but whereas in C. atratus this leads to the expected melanism, in Coscoroba other genetic variation, e.g. at one or more loci downstream of MC1R, influences the phenotype.
Positive_regulation (increased) of MC1R associated with freckles
8) Confidence 0.69 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2553801 Disease Relevance 0.16 Pain Relevance 0
Activation of MC1R seems to be pivotal for UV-induced melanogenesis, since stimulation of the cAMP pathway plays a key role in the melanogenic response of human epidermal melanocytes.
Positive_regulation (Activation) of MC1R in melanocytes associated with melanocortin 1 receptor
9) Confidence 0.69 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816645 Disease Relevance 0.07 Pain Relevance 0.73
The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.
Positive_regulation (activation) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
10) Confidence 0.68 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.23 Pain Relevance 0.36
The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.
Positive_regulation (activation) of MC1R in melanocytes associated with melanocortin 1 receptor
11) Confidence 0.68 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.23 Pain Relevance 0.36
Exposure to UVR increases the synthesis of the photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene.
Positive_regulation (activation) of MC1R associated with skin cancer
12) Confidence 0.67 Published 2006 Journal FASEB J. Section Abstract Doc Link 16877522 Disease Relevance 0.20 Pain Relevance 0.07
The MC1R is activated by ?
Positive_regulation (activated) of MC1R associated with melanocortin 1 receptor
13) Confidence 0.66 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0 Pain Relevance 0.25
The immunomodulatory and anti-inflammatory effects of nonpeptidic, low molecular weight compounds activating the melanocortin-1 receptor (MC1R) provide a new principle for treating various types of inflammation, such as dermal, joint, and gastrointestinal, probably by virtue of the effects acting through modulation of proinflammatory and anti-inflammatory cytokines.
Spec (probably) Positive_regulation (activating) of MC1R in joint associated with melanocortin 1 receptor, inflammation and cytokine
14) Confidence 0.66 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851301 Disease Relevance 0.54 Pain Relevance 0.61
Further, it may work as one of the stimulatory factors for UVB-induced melanogenesis by upregulating MSH-R binding activity in combination with the enhanced DNA synthesis by alpha-MSH.
Positive_regulation (upregulating) of MSH-R
15) Confidence 0.63 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.38 Pain Relevance 0.08
Activation of the MC1R by binding of an agonist stimulates the synthesis of eumelanin primarily via activation of adenylate cyclase.
Positive_regulation (Activation) of MC1R associated with melanocortin 1 receptor and agonist
16) Confidence 0.61 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.13 Pain Relevance 0.83
These results demonstrate activation of the MC1R by tripeptide melanocortin analogs.
Positive_regulation (activation) of MC1R
17) Confidence 0.60 Published 2009 Journal Pigment cell & melanoma research Section Abstract Doc Link 19558415 Disease Relevance 0.05 Pain Relevance 0.07
Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.
Positive_regulation (upregulation) of melanocortin-1 receptor in epidermis associated with melanocortin 1 receptor
18) Confidence 0.51 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.38 Pain Relevance 0.29
The human melanocortin-1 receptor (MC1R) gene, which plays a crucial role in pigmentation, also appears to be important in malignant melanoma (MM).
Spec (appears) Positive_regulation (important) of MC1R in pigmentation associated with melanocortin 1 receptor and skin cancer
19) Confidence 0.50 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17434924 Disease Relevance 0.37 Pain Relevance 0.28
Therefore, MC1R FST was calculated for each of the described populations (Table 5).
Positive_regulation (calculated) of MC1R
20) Confidence 0.50 Published 2008 Journal BMC Genet Section Body Doc Link PMC2324112 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox