INT62175

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.47
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
body 1
cox1 (Schizosaccharomyces pombe)
cox2 (Schizosaccharomyces pombe)
Pain Term Frequency Confidence Heat
COX2 9 100.00 Very High Very High Very High
COX-2 inhibitor 6 100.00 Very High Very High Very High
cINOD 38 100.00 Very High Very High Very High
cOX1 5 100.00 Very High Very High Very High
Inflammation 11 99.32 Very High Very High Very High
Analgesic 2 98.12 Very High Very High Very High
Pain 4 96.04 Very High Very High Very High
tolerance 3 94.64 High High
Arthritis 7 94.16 High High
rheumatoid arthritis 4 81.52 Quite High
Disease Term Frequency Confidence Heat
Toxicity 9 99.76 Very High Very High Very High
INFLAMMATION 20 99.32 Very High Very High Very High
Pain 4 96.04 Very High Very High Very High
Arthritis 7 94.16 High High
Rheumatoid Arthritis 4 81.52 Quite High
Disease 1 76.68 Quite High
Hemorrhage 2 76.40 Quite High
Peptic Ulcer 1 75.04 Quite High
Injury 1 62.40 Quite High
Arthropathy 1 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Drugs selective for COX-2 probably act by binding to a pocket in the enzyme that is present in COX-2 but not in COX-1.
COX-1 Binding (binding) of COX-2
1) Confidence 0.01 Published 2000 Journal Drugs Section Abstract Doc Link 10882157 Disease Relevance 0.72 Pain Relevance 0.49
Work in the past 15 years has shown that COX exists in two forms: COX1, which is largely associated with physiological functions, and COX2, which is largely associated with pathological functions.
COX1 Binding (associated) of COX2 associated with cox2 and cox1
2) Confidence 0.01 Published 2006 Journal Nat Rev Drug Discov Section Abstract Doc Link 16485347 Disease Relevance 0.17 Pain Relevance 0.59
CONCLUSIONS: Although there is a very large body of evidence comparing Cox-2 NSAIDs with Cox-1 NSAIDs, this is not matched by studies of the other types of gastroprotectors or by studies directly comparing active gastroprotective strategies.
Cox-1 Binding (comparing) of Cox-2 in body
3) Confidence 0.00 Published 2006 Journal Health Technol Assess Section Body Doc Link 17018227 Disease Relevance 0 Pain Relevance 0
Current NSAIDs inhibit both COX-1 and COX-2, although the clinical benefit of NSAIDs appears to be associated with inhibition of COX-2 activity.
COX-1 Binding (associated) of COX-2 associated with cinod
4) Confidence 0.00 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973394 Disease Relevance 0.43 Pain Relevance 0.68
The recognition of two COX isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), both suppressed by traditional NSAIDs, has led to an expanded hypothesis of NSAID action which consists of two postulates, namely, the efficacy of NSAIDs in the treatment of arthritis is due to the suppression of COX-2, while much of the toxicity associated with non-selective NSAIDs is the consequence of COX-1 suppression.
COX-1 Binding (recognition) of COX-2 associated with toxicity, cinod and arthritis
5) Confidence 0.00 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772254 Disease Relevance 1.09 Pain Relevance 1.06
Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID), which has a higher activity against cyclooxygenase-2 (COX-2) than against cyclooxygenase-1 (COX-1), with potentially high anti-inflammatory and analgesic action.
COX-1 Binding (activity) of COX-2 associated with inflammation, analgesic and cinod
6) Confidence 0.00 Published 1996 Journal Br. J. Rheumatol. Section Abstract Doc Link 8630633 Disease Relevance 0.43 Pain Relevance 0.45
We employed rapid-mixing techniques and fluorescence quenching to monitor the association and dissociation of a selective COX-2 inhibitor to COX-1 or COX-2.
COX-1 Binding (association) of COX-2 associated with cox-2 inhibitor
7) Confidence 0.00 Published 2000 Journal Biochemistry Section Abstract Doc Link 10821698 Disease Relevance 0.25 Pain Relevance 0.29
[New NSAIDS: COX-1, COX-2, what about them?].
COX-1 Binding (about) of COX-2 associated with cox1
8) Confidence 0.00 Published 1998 Journal Rev Med Brux Section Title Doc Link 9805982 Disease Relevance 0.38 Pain Relevance 0.64

General Comments

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