INT62195

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 11.51
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
body 2
nucleus 1
HSF 1
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 5 99.08 Very High Very High Very High
anesthesia 5 97.76 Very High Very High Very High
ischemia 13 97.36 Very High Very High Very High
Inflammation 2 58.16 Quite High
Central nervous system 1 51.48 Quite High
addiction 2 50.00 Quite Low
qutenza 6 25.36 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 244 100.00 Very High Very High Very High
Stress 104 99.92 Very High Very High Very High
Fever 32 98.98 Very High Very High Very High
INFLAMMATION 7 98.96 Very High Very High Very High
Cv Unclassified Under Development 9 97.36 Very High Very High Very High
Apoptosis 55 94.32 High High
Myeloid Leukemia 72 93.00 High High
Chronic Myeloid Leukemia 48 92.80 High High
Targeted Disruption 96 91.20 High High
Disease 15 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of heat shock factor 1 (HSF1) is known to associate with cellular response to divergent pathophysiological stresses including whole body hyperthermia (WBH) and ischemia-reperfusion.
Positive_regulation (Induction) of HSF1 in body associated with stress, ischemia, shock and fever
1) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.78 Pain Relevance 0.08
Induction of heat shock factor 1 (HSF1) is known to associate with cellular response to divergent pathophysiological stresses including whole body hyperthermia (WBH) and ischemia-reperfusion.
Positive_regulation (Induction) of heat shock factor 1 in body associated with stress, ischemia, shock and fever
2) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.78 Pain Relevance 0.08
Comparison of heat shock and drug-induced forms of HSF1 has revealed that the transcriptionally inert drug-induced HSF1 is constitutively but not inducibly serine-phosphorylated, whereas heat shock-induced HSF1 is both constitutively and inducibly serine-phosphorylated.
Positive_regulation (induced) of HSF1 associated with shock
3) Confidence 0.65 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.75 Pain Relevance 0.07
Comparison of heat shock and drug-induced forms of HSF1 has revealed that the transcriptionally inert drug-induced HSF1 is constitutively but not inducibly serine-phosphorylated, whereas heat shock-induced HSF1 is both constitutively and inducibly serine-phosphorylated.
Positive_regulation (induced) of HSF1 associated with shock
4) Confidence 0.65 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.76 Pain Relevance 0.08
The transcriptionally inert intermediate represented by drug-induced HSF1 can be converted to the transcriptionally active state by a subsequent exposure to heat shock.
Positive_regulation (induced) of HSF1 associated with shock
5) Confidence 0.65 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.73 Pain Relevance 0.07
Exposure of mammalian cells in culture to the anti-inflammatory drugs sodium salicylate or indomethacin results in activation of heat shock factor 1 (HSF1) DNA binding activity.
Positive_regulation (activation) of HSF1 associated with inflammation, shock and cinod
6) Confidence 0.65 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.63 Pain Relevance 0.10
However, a direct cause-effect relationship between HSF1 activation and cytoprotection induced by myocardial preconditioning has not been conclusively established, mainly due to the limitations of available experiment tools.
Positive_regulation (activation) of HSF1
7) Confidence 0.47 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.90 Pain Relevance 0.14
WBH preconditioning resulted in 2.7-fold and 3.4-fold increase in cardiac HSF1 mRNA and protein expression respectively 2 hours after WBH, which was inhibited in the siRNA-treated mice.
Positive_regulation (increase) of HSF1 associated with fever
8) Confidence 0.47 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 1.03 Pain Relevance 0.17
Regulation of the Hsp genes by heat or chemical-induced oxidative stress is controlled in part by HS factor 1 (HSF1), activated under conditions in which the level of unfolded proteins increase [1-3].
Positive_regulation (activated) of HSF1 associated with stress and shock
9) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.14 Pain Relevance 0.03
We have previously shown that the drug-induced HSF1 becomes associated with the heat shock elements of the hsp70 promoter, yet transcription of the hsp70 gene is not induced (Jurivich, D.
Positive_regulation (induced) of HSF1 associated with shock
10) Confidence 0.43 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.65 Pain Relevance 0.09
In mammalian cells, induction of HSP70 requires activation and nuclear localization of HSF-1 [30], [31].
Positive_regulation (activation) of HSF-1 in HSF
11) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.64 Pain Relevance 0.03
The HSF1 activation and translocation to the nucleus is dependent on phosphorylation of its multiple amino acid residues [32].
Positive_regulation (activation) of HSF1 in nucleus
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
In our present study we have tried to decipher the signaling pathways that contribute to the constitutive activation of HSF1 in K562 cells.
Positive_regulation (activation) of HSF1
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.55 Pain Relevance 0
Since Heat Shock Factor 1 (HSF1) controls transcription of Hsp70, we wanted to probe the signaling pathways responsible for transcriptional activation of HSF1.


Positive_regulation (activation) of HSF1 associated with shock
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.62 Pain Relevance 0
These in turn inactivate HSF1 so as to decrease Hsp70 expression in K562 cells in presence of Resveratrol.
Positive_regulation (inactivate) of HSF1
15) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
In cases where this co-ordination of HSF1 activation, stress response and post recovery deactivation mechanism is not well co-ordinated, the Hsps become highly overexpressed.
Positive_regulation (activation) of HSF1 associated with stress
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 1.39 Pain Relevance 0
Since Resveratrol blocked Akt activation it was essential to demonstrate if Akt activation pathway was involved in modulating the subcellular distribution and activation of HSF1, the transcription factor responsible for expression of hsp70 gene.
Positive_regulation (activation) of HSF1
17) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.17 Pain Relevance 0

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