INT62196

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 2.72
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
nucleus 2
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 99.30 Very High Very High Very High
ischemia 3 97.36 Very High Very High Very High
anesthesia 1 60.80 Quite High
qutenza 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 31 100.00 Very High Very High Very High
INFLAMMATION 1 99.18 Very High Very High Very High
Cv Unclassified Under Development 2 97.36 Very High Very High Very High
Fever 8 96.80 Very High Very High Very High
Apoptosis 24 95.60 Very High Very High Very High
Stress 35 95.24 Very High Very High Very High
Myeloid Leukemia 36 94.28 High High
Chronic Myeloid Leukemia 24 94.08 High High
Blast Crisis 3 90.68 High High
Reperfusion Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a direct cause-effect relationship between HSF1 activation and cytoprotection induced by myocardial preconditioning has not been conclusively established, mainly due to the limitations of available experiment tools.
Positive_regulation (induced) of Positive_regulation (activation) of HSF1
1) Confidence 0.47 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.91 Pain Relevance 0.15
Exposure of mammalian cells in culture to the anti-inflammatory drugs sodium salicylate or indomethacin results in activation of heat shock factor 1 (HSF1) DNA binding activity.
Positive_regulation (results) of Positive_regulation (activation) of HSF1 associated with inflammation, shock and cinod
2) Confidence 0.43 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.63 Pain Relevance 0.10
Since Heat Shock Factor 1 (HSF1) controls transcription of Hsp70, we wanted to probe the signaling pathways responsible for transcriptional activation of HSF1.


Positive_regulation (responsible) of Positive_regulation (activation) of HSF1 associated with shock
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.62 Pain Relevance 0
The HSF1 activation and translocation to the nucleus is dependent on phosphorylation of its multiple amino acid residues [32].
Positive_regulation (dependent) of Positive_regulation (activation) of HSF1 in nucleus
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
In our present study we have tried to decipher the signaling pathways that contribute to the constitutive activation of HSF1 in K562 cells.
Positive_regulation (contribute) of Positive_regulation (activation) of HSF1
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.55 Pain Relevance 0

General Comments

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