INT62199

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.77
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
HSF 2
body 2
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 98.38 Very High Very High Very High
ischemia 9 95.64 Very High Very High Very High
fibrosis 10 93.56 High High
addiction 2 67.44 Quite High
Hsan 1 55.12 Quite High
hypoalgesia 8 50.00 Quite Low
diabetic neuropathy 4 49.04 Quite Low
anesthesia 4 42.80 Quite Low
Central nervous system 2 37.00 Quite Low
agonist 6 21.84 Low Low
Disease Link Frequency Relevance Heat
Shock 228 100.00 Very High Very High Very High
INFLAMMATION 5 98.26 Very High Very High Very High
Targeted Disruption 199 98.16 Very High Very High Very High
Stress 85 97.76 Very High Very High Very High
Chronic Myeloid Leukemia 16 97.52 Very High Very High Very High
Fever 16 96.56 Very High Very High Very High
Cv Unclassified Under Development 8 95.64 Very High Very High Very High
Fibrosis 10 93.56 High High
Coronary Heart Disease 60 87.80 High High
Disease 32 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of mammalian cells in culture to the anti-inflammatory drugs sodium salicylate or indomethacin results in activation of heat shock factor 1 (HSF1) DNA binding activity.
HSF1 Binding (binding) of associated with inflammation, shock and cinod
1) Confidence 0.45 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.63 Pain Relevance 0.10
Since it is known that protein interaction between heat shock factor (HSF) and HSP70, as well as nuclear translocation of HSF is important for HSP induction by GGA [20], the effect of GGA on HSF1 localization was examined (Figure 3F).
heat shock factor Spec (examined) Binding (interaction) of in HSF associated with shock
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.64 Pain Relevance 0.08
Induction of heat shock factor 1 (HSF1) is known to associate with cellular response to divergent pathophysiological stresses including whole body hyperthermia (WBH) and ischemia-reperfusion.
HSF1 Binding (associate) of in body associated with stress, ischemia, shock and fever
3) Confidence 0.36 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.84 Pain Relevance 0.09
Induction of heat shock factor 1 (HSF1) is known to associate with cellular response to divergent pathophysiological stresses including whole body hyperthermia (WBH) and ischemia-reperfusion.
heat shock factor 1 Binding (associate) of in body associated with stress, ischemia, shock and fever
4) Confidence 0.36 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.84 Pain Relevance 0.09
Genes have been identified that possess HSEs that bind HSF1 but that were not HS-inducible.
HSF1 Binding (bind) of associated with shock
5) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.01 Pain Relevance 0.03
These data reveal that acquisition of the trimeric DNA binding state of HSF1 is independent of and precedes inducible phosphorylation and furthermore that inducible phosphorylation correlates with transcriptional activation.
HSF1 Binding (binding) of
6) Confidence 0.33 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.66 Pain Relevance 0.06
Exposure of mammalian cells in culture to the anti-inflammatory drugs sodium salicylate or indomethacin results in activation of heat shock factor 1 (HSF1) DNA binding activity.
HSF1 Binding (activity) of associated with inflammation, shock and cinod
7) Confidence 0.33 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631933 Disease Relevance 0.64 Pain Relevance 0.10
Although transcriptional activity of the HSF1 is uncertain, depending on the location of HSF1 as assessed immunohistochemically, the HSP70-HSF interaction is not sufficient to explain GGA's effects completely.
HSF1 Binding (activity) of in HSF
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.42 Pain Relevance 0
Hsp90 (heat-shock protein 90) is the master regulator of the HSR (heat-shock response) since it binds HSF1 (heat-shock factor 1).
heat-shock factor 1 Binding (binds) of associated with shock
9) Confidence 0.23 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 1.05 Pain Relevance 0
Hsp90 (heat-shock protein 90) is the master regulator of the HSR (heat-shock response) since it binds HSF1 (heat-shock factor 1).
HSF1 Binding (binds) of associated with shock
10) Confidence 0.23 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 1.00 Pain Relevance 0
Hsf1 is rapidly responsive to extra- or intracellular signals to activate transcription, but the response can be halted just as quickly by Hsbp1 disrupting the trimerization of Hsf1 thus preventing its binding to heat shock elements (HSEs) [75].
Hsf1 Binding (binding) of associated with shock
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.50 Pain Relevance 0.06
Overexpression of the heat-shock protein 70 is associated with Imatinib resistance in chronic myeloid leukemia [15].We have previously reported that Resveratrol alters sub cellular localization, transcriptional activity, and promoter binding of the HSF1 that in turn downregulates gene expression of hsp70 [11].
HSF1 Binding (binding) of associated with shock and chronic myeloid leukemia
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.86 Pain Relevance 0
Recent evidence also claims that negative regulation of HSF1 can be accomplished by its acetylation at K80 [21].
HSF1 Binding (accomplished) of
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.67 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox