INT62207

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Context Info
Confidence 0.06
First Reported 1996
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.29

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small molecule metabolic process (PTGS1, PTGS2) endoplasmic reticulum (PTGS1, PTGS2) cytoplasm (PTGS1, PTGS2)
lipid binding (PTGS1, PTGS2) oxidoreductase activity (PTGS1, PTGS2) nucleus (PTGS1, PTGS2)
PTGS1 (Homo sapiens)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 97.28 Very High Very High Very High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KI values associated with the formation of the first reversible complex (EI) for flurbiprofen with PGHS1 and PGHS2 were 0.53 +/- 0. 06 and 0.61 +/- 0.08 microM, respectively; the rate constants for the forward isomerization, k2, into the second reversible complex (EI*) were 0.97 +/- 0.99 and 0.11 +/- 0.01 s-1, respectively, and rates of the reverse isomerization from EI*, k-2, were 0.031 +/- 0.004 and 0.0082 +/- 0.0008 s-1, respectively.
PGHS1 Binding (formation) of PGHS2
1) Confidence 0.06 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.10
These results show that the overall affinity for the inhibition of PGHS1 versus PGHS2 was 30-fold greater for indomethacin (KI* = 0.032 +/- 0.005 and 1.02 +/- 0.08 microM, respectively) and 3-fold greater for flurbiprofen (KI* = 0.017 +/- 0.002 and 0.045 +/- 0.004 microM, respectively).
PGHS1 Binding (affinity) of PGHS2
2) Confidence 0.06 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.12
In studies reported here, membrane-associated forms of oPGHS-1 and hPGHS-2 were labeled using the hydrophobic, photoactivable reagent 3-trifluoro-3-(m-[(125)I]iodophenyl)diazirine, isolated, and cleaved with AspN and/or GluC, and the photolabeled peptides were sequenced.
oPGHS-1 Binding (forms) of hPGHS-2
3) Confidence 0.04 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10551860 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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