INT62240

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.91
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1d) signal transducer activity (Htr1d)
Anatomy Link Frequency
5-HT neurons 1
vesicles 1
Htr1d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
tetrodotoxin 3 99.00 Very High Very High Very High
Sumatriptan 4 97.36 Very High Very High Very High
Sciatic nerve 1 90.16 High High
agonist 3 87.68 High High
unmyelinated 1 86.08 High High
dorsal root ganglion 3 82.88 Quite High
trigeminal ganglion 3 82.28 Quite High
monoamine 2 82.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 82.88 Quite High
Aids-related Complex 22 75.84 Quite High
Cluster Headache 1 75.00 Quite High
Osteogenic Sarcomas 4 68.40 Quite High
Bordatella Infection 1 60.96 Quite High
Migraine Disorders 1 54.20 Quite High
Cocaine Dependence 20 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the ultrastructural level, 5-HT1D receptors in the spinal cord dorsal horn are localized exclusively within dense core vesicles of synaptic terminals.
Localization (localized) of 5-HT1D in vesicles associated with dorsal horn and spinal cord
1) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14645495 Disease Relevance 0.57 Pain Relevance 1.28
Neither the inhibitory effect of sumatriptan nor that of 5-carboxyamidotryptamine were reduced by the addition of tetrodotoxin to the superfusion medium, suggesting that these 5-HT1D receptors are located on 5-HT neurons and may be considered autoreceptors.
Localization (located) of 5-HT1D in 5-HT neurons associated with tetrodotoxin and sumatriptan
2) Confidence 0.73 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632339 Disease Relevance 0.06 Pain Relevance 1.10
The 5-hydroxytryptamine receptor 1d (Htr1d), which was decreased at 1-day (28%) and remained decreased at 10-days (20%) represents the only confirmed category 2 change (Figure 3B).
Localization (decreased) of Htr1d
3) Confidence 0.39 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.14 Pain Relevance 0.23
The 5-hydroxytryptamine receptor 1d (Htr1d), which was decreased at 1-day (28%) and remained decreased at 10-days (20%) represents the only confirmed category 2 change (Figure 3B).
Localization (decreased) of Htr1d
4) Confidence 0.39 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.14 Pain Relevance 0.21

General Comments

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