INT62247

Context Info Confidence 0.08 First Reported 1996 Last Reported 1996 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.82

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)

Anatomy Link Frequency pituitary 2 Fdft1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 6 100.00 Clonidine 10 98.56 agonist 1 83.16

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Acute administration of CLO significantly decreased hypothalamic GHRH content [leaving unaltered GHRH messenger RNA (mRNA) levels] and increased plasma GH levels; hypothalamic SS content/mRNA levels and pituitary GH content/mRNA levels remained unchanged.

Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of SS in pituitary associated with somatostatin and clonidine

1) Confidence 0.08 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.82

General Comments

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