INT62253

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.98
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FLII) cytoskeleton (FLII) nucleus (FLII)
cytoplasm (FLII)
Anatomy Link Frequency
spinal cord 2
FLII (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 100.00 Very High Very High Very High
Hyperalgesia 4 100.00 Very High Very High Very High
Dorsal horn 2 92.08 High High
antinociception 1 90.00 High High
narcan 4 88.96 High High
Thermal hyperalgesia 1 88.72 High High
spinal dorsal horn 1 87.60 High High
Inflammation 5 84.80 Quite High
carrageenan induced 1 84.16 Quite High
Morphine 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
Pressure And Volume Under Development 3 100.00 Very High Very High Very High
Nociception 5 75.00 Quite High
INFLAMMATION 3 75.00 Quite High
Pain 3 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(vii) A higher level of urethane anaesthesia had a generally suppressive effect on FLI expression.
Regulation (effect) of Gene_expression (expression) of FLI
1) Confidence 0.60 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.21 Pain Relevance 0.18
Finally, neither the inhibitory effect of 4.40 nmol Cl-977 on formalin-evoked behaviors nor the formalin-evoked pattern of FLI expression in the spinal cord of rats treated with this dose of Cl-977 was affected by lesions of the dorsolateral funiculus.
Neg (neither) Regulation (affected) of Gene_expression (expression) of FLI in spinal cord associated with spinal cord
2) Confidence 0.06 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632353 Disease Relevance 0.06 Pain Relevance 0.77
However, blockade of peripheral 5-HT1A receptors by (N-2-[4-(2-methoxyphenyl-1-piperazinyl] ethyl]-N-2-pyridinylcyclohexanecarboxamide at maximally effective doses (30 and 100 mug; i.pl.) did not alter carrageenan-induced hyperalgesia, edema or expression of FLI.
Neg (not) Regulation (alter) of Gene_expression (expression) of FLI associated with pressure and volume under development and hyperalgesia
3) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857711 Disease Relevance 0.70 Pain Relevance 0.78

General Comments

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